Author: David A. Jans
Publisher: Springer Science & Business Media
ISBN: 1475706804
Category : Medical
Languages : en
Pages : 228

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Book Description

Author: Lee E. Limbird
Publisher: Springer Science & Business Media
ISBN: 1461312558
Category : Medical
Languages : en
Pages : 251

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Book Description
Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying principles removes the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, the basic concepts become emphasized. This volume is a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed.

Author:
Publisher: Academic Press
ISBN: 0080584896
Category : Science
Languages : en
Pages : 507

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Book Description
Current Topics in Membranes and Transport

Author: C. M. Chadwick
Publisher: Cambridge University Press
ISBN: 0521304261
Category : Science
Languages : en
Pages : 390

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Book Description
This book takes a broad look at the current status of research on receptors in higher and lower plants. It starts with a discussion of some hormone receptors (auxins, ethylene and gibberellin) in higher plants, and then considers the role of cyclic AMP and its receptors in the slime mould Dictyostelium.

Author: Benga
Publisher: CRC Press
ISBN: 135109386X
Category : Science
Languages : en
Pages : 250

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Book Description
This book provides in-depth presentations in membrane biology by specialists of international repute. The volumes examine world literature on recent advances in understanding the molecular struc-ture and properties of membranes, the role they play in cellular physiology and cell-cell interactions, and the alterations leading to abnormal cells. Illustrations, tables, and useful appendices com-plement the text. Those professionals actively working in the field of cell membrane investigations as well as biologists, biochemists, biophysicists, physicians, and academicians, will find this work beneficial.

Author: P. Cuatrecasas
Publisher: Springer Science & Business Media
ISBN: 9400959753
Category : Science
Languages : en
Pages : 309

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Book Description
This volume focuses exclusively on those endocytic processes that sequester proteins by a selective, receptor-mediated mechanism. In such an endocytic process, cell surface receptors specifically bind protein ligands and localize them to specialized invaginations of the plasma membrane. These regions are coated pits, so named because they are lined on the cytoplasmic face with an ordered array of the protein, clathrin. It is this 'coat' which provides their characteristic electron microscopic image. Subsequently, these regions pinch off to form coated vesicles which rapidly lose their 'coat' and then fuse with other organelles or the plasma membrane. The hallmarks of ,this process are the specific receptors, coated pits, coated vesicles and an ordered sequence of transit events leading to delivery to selected locations. Receptor recognition, specific disposition of the endocytosed ligand and the existence of recep tor-ligand complexes at highest density in coated pits define the process as selective and concentrative. This topic has received ever increasing attention during the past few years. The evolving mechanisms are especially exciting because they come at a time when the conventional views based on thermodynamic arguments suggest that proteins should not be able to cross into the cell. Receptor-mediated endocytosis, however, reconciles the view that biological membranes should be impervious to macromolecules with the evidence that certain mac romolecules do gain entrance into the cell. During the last few years this field has been stimulated by studies on the uptake and processing of low density lipoproteins (LDL) by cells.

Author: David Evered
Publisher: John Wiley & Sons
ISBN: 0470718412
Category : Medical
Languages : en
Pages : 192

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Book Description
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Author: P. CUATRECASAS AND M. F. GREAVES
Publisher: Springer
ISBN: 1489968628
Category : Science
Languages : en
Pages : 207

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Book Description

Author: Abhijit Chakrabarti
Publisher: Springer
ISBN: 3319112805
Category : Science
Languages : en
Pages : 408

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Book Description
Consists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.

Author: Lee E. Limbird
Publisher: Springer Science & Business Media
ISBN: 1475718829
Category : Medical
Languages : en
Pages : 205

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Book Description
The purpose of this book is to serve as a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying prin ciples is intended to remove the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, it is hoped that the basic concepts can be emphasized. This book is meant to be a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed. I feit compelled to write this book for several reasons. The primary philosophical reason was to provide, in one volume, an overall perspective on the study ofcell surface receptors that describes their characterization from pharmacological studies in a whole organ or tissue bath (chapter 2) to studies of radioligand binding in isolated membrane and detergent-solubilized pre parations (chapters 3-5) and, back again, to studies in intact cells or tissues using morphological and biochemical techniques (chapter 6). It is my opinion that the ultimate understanding of the molecular basis for hormone or drug receptor interactions, and the physiological consequences of these inter actions, will require an assessment of cell surface receptor function at all of these experimental levels. In many cases an investigator may not choose to of investigation considered here.