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Author:
Publisher:
ISBN:
Category : Labor unions
Languages : en
Pages : 888
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Book Description
Author:
Publisher:
ISBN:
Category : Labor unions
Languages : en
Pages : 888
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Book Description
Author: Kenneth Lange
Publisher: SIAM
ISBN: 1611974399
Category : Mathematics
Languages : en
Pages : 229
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Book Description
MM Optimization Algorithms?offers an overview of the MM principle, a device for deriving optimization algorithms satisfying the ascent or descent property. These algorithms can separate the variables of a problem, avoid large matrix inversions, linearize a problem, restore symmetry, deal with equality and inequality constraints gracefully, and turn a nondifferentiable problem into a smooth problem.? The author presents the first extended treatment of MM algorithms, which are ideal for high-dimensional optimization problems in data mining, imaging, and genomics; derives numerous algorithms from a broad diversity of application areas, with a particular emphasis on statistics, biology, and data mining; and summarizes a large amount of literature that has not reached book form before.?
Author: György Keserü
Publisher: John Wiley & Sons
ISBN: 352733582X
Category : Medical
Languages : en
Pages : 360
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Book Description
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.
Author:
Publisher: Delene Kvasnicka
ISBN:
Category :
Languages : en
Pages : 876
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Book Description
Author: Daniel Peris
Publisher: Taylor & Francis
ISBN: 1003849245
Category : Business & Economics
Languages : en
Pages : 134
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Book Description
We are on the verge of a major paradigm shift for investors in the U.S. stock market. Dividend-focused stock investing has been receding in popularity for more than three decades in the U.S.; once the dominant investment style, it is now a boutique approach. That is about to change. The Ownership Dividend explains how and why the stock market drifted away from a mostly cash-based returns system to one almost completely driven by near-term share price movements. It details why the exceptional forces behind that shift—notably the 40-year drop in interest rates and the rise of buybacks—are now substantially exhausted. As a result, the U.S. market is poised for a return to the more typical business-like relationships observed in the private sector and in other mature markets around the world. While many market participants have profited from and become used to the way things have been in recent decades, savvy individual investors, financial advisors, and even institutional portfolio managers will want to position themselves to benefit from the reversion to cash-based investment relationships in the years ahead. This is a must-read book for financial advisors, institutional consultants, as well as engaged individual investors.
Author: Aaron James Draplin
Publisher: Abrams
ISBN: 1613129963
Category : Design
Languages : en
Pages : 834
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Book Description
A funny, colorful, fascinating tour through the work and life of one of today’s most influential graphic designers. Esquire. Ford Motors. Burton Snowboards. The Obama Administration. While all of these brands are vastly different, they share at least one thing in common: a teeny little bit of Aaron James Draplin. Draplin is one of the new school of influential graphic designers who combine the power of design, social media, entrepreneurship, and DIY aesthetic to create a successful business and way of life. Pretty Much Everything is a mid-career survey of work, case studies, inspiration, road stories, lists, maps, how-tos, and advice. It includes examples of his work—posters, record covers, logos—and presents the process behind his design with projects like Field Notes and the “Things We Love” State Posters. Draplin also offers valuable advice and hilarious commentary that illustrates how much more goes into design than just what appears on the page. With Draplin’s humor and pointed observations on the contemporary design scene, Pretty Much Everything is the complete package.
Author: Lesley M. M. Blume
Publisher: Knopf Books for Young Readers
ISBN: 0375899189
Category : Juvenile Fiction
Languages : en
Pages : 258
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Book Description
The journals of Dr. Wendell Wellington Wiggins might just be the most extraordinary contribution to the study of the earth's past since the discovery of the Rosetta Stone. In the incredible pages of these thought-to-be-lost diaries, Dr. Wiggins—whom we now must consider the greatest paleozoologist of all time—has divulged the secrets of the truly ancient animal world: a world before human beings; a world before dinosaurs; a world that, until now, existed well beyond the outer reaches of human imagination. From deadly Amazonian Whispering Vines (Vitus Sussurus) to curious creatures called Brittle Bones (Futilis Ossis) to a mysterious pet named Gibear (Chiroptera Vicugna Pacosis), the discoveries of Dr. Wiggins will forever change the way we think about the world before us.
Author: Holger Gohlke
Publisher: John Wiley & Sons
ISBN: 3527645977
Category : Medical
Languages : en
Pages : 359
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Book Description
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.
Author: Pooja A. Chawla
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3111207110
Category : Science
Languages : en
Pages : 440
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Book Description
Computational methods and understanding computational models are important in modern drug discovery. The book focuses on computational approaches that can improve the development of in silico methodologies. It includes lead hit methods, docking algorithms, computational chiral compounds, structure-based drug design, GROMACS and NAMD, structural genomics, toxicity prediction, enzyme inhibitors and peptidomimetic therapeutics
Author: Steven R. Schmid
Publisher: CRC Press
ISBN: 1482206951
Category : Science
Languages : en
Pages : 626
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Book Description
Fundamentals of Machine Elements, Third Edition offers an in-depth understanding of both the theory and application of machine elements. Design synthesis is carefully balanced with design analysis, an approach developed through the use of case studies, worked examples, and chapter problems that address all levels of learning taxonomies. Machine des
