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Author: Dennis Kavanagh
Publisher: Pan
ISBN:
Category : History
Languages : en
Pages : 520
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Book Description
John Major's rise to leader of the Conservative Party and Prime Minister was meteoric and surprising. When he became Chancellor in 1989 few voters knew his name and his replacement of Margaret Thatcher seemed even more bewildering. This book provides an overview of John Major's premiership.
Author: Dennis Kavanagh
Publisher: Pan
ISBN:
Category : History
Languages : en
Pages : 520
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Book Description
John Major's rise to leader of the Conservative Party and Prime Minister was meteoric and surprising. When he became Chancellor in 1989 few voters knew his name and his replacement of Margaret Thatcher seemed even more bewildering. This book provides an overview of John Major's premiership.
Author:
Publisher:
ISBN:
Category : Agriculture
Languages : en
Pages : 192
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Book Description
Author: Alex Prud'homme
Publisher: Simon and Schuster
ISBN: 1439168490
Category : Political Science
Languages : en
Pages : 450
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Book Description
AS ALEX PRUD’HOMME and his great-aunt Julia Child were completing their collaboration on her memoir, My Life in France, they began to talk about the French obsession with bottled water, which had finally spread to America. From this spark of interest, Prud’homme began what would become an ambitious quest to understand the evolving story of freshwater. What he found was shocking: as the climate warms and world population grows, demand for water has surged, but supplies of freshwater are static or dropping, and new threats to water quality appear every day. The Ripple Effect is Prud’homme’s vivid and engaging inquiry into the fate of freshwater in the twenty-first century. The questions he sought to answer were urgent: Will there be enough water to satisfy demand? What are the threats to its quality? What is the state of our water infrastructure—both the pipes that bring us freshwater and the levees that keep it out? How secure is our water supply from natural disasters and terrorist attacks? Can we create new sources for our water supply through scientific innovation? Is water a right like air or a commodity like oil—and who should control the tap? Will the wars of the twenty-first century be fought over water? Like Daniel Yergin’s classic The Prize: The Epic Quest for Oil, Money & Power, Prud’homme’s The Ripple Effect is a masterwork of investigation and dramatic narrative. With striking instincts for a revelatory story, Prud’homme introduces readers to an array of colorful, obsessive, brilliant—and sometimes shadowy—characters through whom these issues come alive. Prud’homme traversed the country, and he takes readers into the heart of the daily dramas that will determine the future of this essential resource—from the alleged murder of a water scientist in a New Jersey purification plant, to the epic confrontation between salmon fishermen and copper miners in Alaska, to the poisoning of Wisconsin wells, to the epidemic of intersex fish in the Chesapeake Bay, to the wars over fracking for natural gas. Michael Pollan has changed the way we think about the food we eat; Alex Prud’homme will change the way we think about the water we drink. Informative and provocative, The Ripple Effect is a major achievement.
Author: D. A. Roe
Publisher: CRC Press
ISBN: 1000110540
Category : Health & Fitness
Languages : en
Pages : 622
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Book Description
This book is devoted to the effects of food and of nutrient intake on the disposition of foreign compounds, and discusses effects of drugs on nutrition. It is intended for nutritionists and clinical investigators concerned with interpretation of aberrant effects of therapeutic drugs.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 656
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Book Description
Author: David B. Burr
Publisher: Academic Press
ISBN: 0128132604
Category : Reference
Languages : en
Pages : 480
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Book Description
Basic and Applied Bone Biology, Second Edition, provides an overview of skeletal biology, from the molecular level, to the organ level, including cellular control, interaction and response, adaptive responses to various external stimuli, and the interaction of the skeletal system with other metabolic processes in the body. The book includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically-modified animal models. Each chapter delves deep into the important details of topics covered to provide a solid understanding of the basics of bone biology. Bone biology researchers who also train undergraduate and graduate students in the lab will use this book constantly to orient new students on the basics of the field and as a background reference for many of the technical aspects of qualification in bone biology (e.g., mechanics, histomorphometry, genetic modification, biochemistry, etc.). - Presents an in-depth overview of skeletal biology, from molecular to organ level - Offers refresher level content for clinicians or researchers outside their areas of expertise - Includes updated and complete references - Incorporates expanded study questions at the end of each chapter for further exploration - Covers topics relevant to a modern course in skeletal biology
Author: Laszlo Urban
Publisher: John Wiley & Sons
ISBN: 3527673679
Category : Medical
Languages : en
Pages : 528
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Book Description
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.
Author: Wanda M. Haschek
Publisher: Elsevier
ISBN: 0080491448
Category : Medical
Languages : en
Pages : 2160
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Book Description
A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology. This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury. Key Features * Easy to find, up-to-date reference information * Graphic and photographic plates * Current hot topics and anticipated changes in toxicologic pathology * Standardized chapter format * Topics that are addressed in both a broad and deep manner, resulting in a stand alone text * Added coverage of important environmental toxicants * Chapters authored by internationally recognized experts and peer-reviewed
Author: International Monetary Fund
Publisher: International Monetary Fund
ISBN: 1451943555
Category : Business & Economics
Languages : en
Pages : 212
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Book Description
This paper reviews recent analytical and empirical research on the determination of employment, to provide a framework for evaluating the merits of alternative policies to cope with unemployment. Particular emphasis is placed on the mechanisms of employment and wage determination described in recent studies. The lack of any systematic relationship between countries' long-run growth and employment performances reflects the fact that output per person employed (labor productivity) or, conversely, the labor intensity of production, has developed quite differently across countries. The main mechanism through which the rise in real wages has prevented greater employment gains in Europe over the past ten to fifteen years seems to have been a substitution of capital for labor which has lowered the labor intensity of production significantly more than in the United States. There are a number of important caveats with respect to the apparent relationship between differences in employment and labor cost developments across countries.
Author: John Demosthenes N. Ruffin
Publisher:
ISBN:
Category : Logic
Languages : en
Pages : 128
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Book Description
