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Author: Farouk Shakib
Publisher: Elsevier
ISBN: 1483287203
Category : Medical
Languages : en
Pages : 321
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Book Description
This book features contributions from internationally renowned scientists from Europe and the USA covering aspects of immunoglobulin subclasses from a molecular and mechanistic approach. The first section presents a detailed discussion of the molecular structure and segmental flexibility of IgG subclasses, including how this controls their effector function. Structure-function relationships are fully developed in the second section by means of a functional approach to the study of complement activation and opsonization by IgG subclasses. The final section contains a generous account of the regulation of IgG subclass expressions.
Author: Farouk Shakib
Publisher: Elsevier
ISBN: 1483287203
Category : Medical
Languages : en
Pages : 321
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Book Description
This book features contributions from internationally renowned scientists from Europe and the USA covering aspects of immunoglobulin subclasses from a molecular and mechanistic approach. The first section presents a detailed discussion of the molecular structure and segmental flexibility of IgG subclasses, including how this controls their effector function. Structure-function relationships are fully developed in the second section by means of a functional approach to the study of complement activation and opsonization by IgG subclasses. The final section contains a generous account of the regulation of IgG subclass expressions.
Author: Theo Rispens
Publisher: Elsevier Inc. Chapters
ISBN: 0128060301
Category : Medical
Languages : en
Pages : 46
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Book Description
Immunoglobulins are a group of closely related glycoproteins composed of 82 to 96% protein and 4 to 18% carbohydrate. In humans, there are five classes of immunoglobulins, which differ in heavy-chain structure. Immunoglobulin G (IgG) is the major class of immunoglobulins in blood and can be further subdivided in subclasses. The four subclasses of IgG were discovered in the 1960s following extensive studies using specific rabbit antisera against human IgG myeloma proteins.1 They are designated IgG1, IgG2, IgG3, and IgG4, in order of decreasing abundance. Several decades of research has revealed subtle but profound differences among the subclasses. Each subclass has a unique profile with respect to antigen binding, immune complex formation, complement activation, triggering of effector cells, and placental transport (Table 9.1). In addition, IgG antibody responses to different types of antigens or pathogens often lead to marked skewing toward one of the subclasses. On the other hand, selective subclass deficiencies are usually not detrimental to the individual but do sometimes lead to enhanced susceptibility toward specific classes of pathogens. All in all, the acquired variability within the Ig locus seems to have been selected for beneficial changes during evolution for optimizing or fine-tuning the antibody-mediated immune response.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Robert G. Hamilton
Publisher:
ISBN:
Category : Immunoglobulin G.
Languages : en
Pages : 76
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Book Description
Author: Farouk Shakib
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Roland J. Levinsky
Publisher:
ISBN:
Category : Immunoglobulin G
Languages : en
Pages : 84
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Author: Natalie McCloskey
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: F. Skvaril
Publisher:
ISBN: 9783805546713
Category : Medical
Languages : en
Pages : 346
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 522
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Author: Farouk Ibrahim Shakib
Publisher:
ISBN:
Category :
Languages : en
Pages :
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