Author: Hagai Bergman
Publisher: MIT Press
ISBN: 0262367297
Category : Science
Languages : en
Pages : 333
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Book Description
The anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values. The main task of the basal ganglia—a group of subcortical nuclei, located at the base of the brain—is to optimize and execute our automatic behavior. In this book, Hagai Bergman analyzes the anatomy and physiology of the basal ganglia, discussing their relation to brain and behavior, to disorders and therapies, and even to moral values. Drawing on his forty years of studying the basal ganglia, Bergman presents new information on physiology and computational models, Parkinson’s disease and other ganglia-related disorders, and such therapies as deep brain stimulation. Focusing on studies of nonhuman primates and human basal ganglia and relying on system physiology and in vivo extra-cellular recording techniques, Bergman first describes the major brain structures that constitute the basal ganglia, the morphology of their cellular elements, their synaptic connectivity and their physiological function in health and disease. He discusses the computational physiology of the healthy basal ganglia, describing four generations of computational models, and then traces the computational physiology of basal ganglia–related disorders and their treatments, including Parkinson’s disease and its pharmacological and surgical therapies. Finally, Bergman considers the implications of these findings for such moral concerns as free will. Explaining this leap into domains rarely explored in neuroscientific accounts, Bergman writes that the longer he studies the basal ganglia, the more he is convinced that they are truly the base of both brain and mind.
Author: Benjamin Stecher
Publisher: Springer Nature
ISBN: 3031503996
Category :
Languages : en
Pages : 161
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Book Description
Author: Melinda Powell
Publisher: Kings Road Publishing
ISBN: 1788702395
Category : Self-Help
Languages : en
Pages : 230
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Book Description
On average, we spend around six years of our lives dreaming. Yet, astonishingly, few of us understand the purpose of dreams and even fewer recognise what our dreaming mind can tell us about ourselves and our world. Melinda Powell, psychotherapist and co-founder of the Dream Research Institute UK, reveals how better understanding our dreams can improve our waking lives. As well as examining the importance of sleep and dreams, The Hidden Lives of Dreams explores the role of light, colour, landscapes, space, healing presence and lucidity in dreams, dispels common misconceptions and addresses our fears of nightmares. Powell shows how to tap into our dreams as a source of guidance and inspiration to enhance our wellbeing and to discover a healthier, more balanced approach to life. 'Exploring the depths of dreaming with an experienced guide like Melinda Powell will bring you closer to your heart, your purpose and your truest self. Highly recommended.' Robert Waggoner
Author: Andreas Horn
Publisher: Academic Press
ISBN: 0128218622
Category : Medical
Languages : en
Pages : 602
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Book Description
Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) Presents references (key articles, books and protocols) for additional detailed study Provides data analysis boxes in each chapter to help with data interpretation
Author: Sten Grillner
Publisher: MIT Press
ISBN: 0262072785
Category : Anatomy
Languages : en
Pages : 471
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Book Description
Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior. Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different aspects of motor behavior. In this Dahlem Workshop volume, leading neuroscientists discuss how microcircuits work to bridge the single cell and systems levels and compare the intrinsic function of microcircuits with their ion channel subtypes, connectivity, and receptors, in order to understand the design principles and function of the microcircuits. The chapters cover the four major areas of microcircuit research: motor systems, including locomotion, respiration, and the saccadic eye movements; the striatum, the largest input station of the basal ganglia; olfactory systems and the neural organization of the glomeruli; and the neocortex. Each chapter is followed by a group report, a collaborative discussion among senior scientists. Contributors Lidia Alonso-Nanclares, Hagai Bergman, Maria Blatow, J. Paul Bolam, Ansgar Büschges, Antonio Caputi, Jean-Pierre Changeux, Javier DeFelipe, Carsten Duch, Paul Feinstein, Stuart Firestein, Yves Frégnac, Rainer W. Friedrich, C. Giovanni Galizia, Ann M. Graybiel, Charles A. Greer, Sten Grillner, Tadashi Isa, Ole Kiehn, Minoru Kimura, Anders Lanser, Gilles Laurent, Pierre-Marie Lledo, Wolfgang Maass, Henry Markram, David A. McCormick, Christoph M. Michel, Peter Mombaerts, Hannah Monyer, Hans-Joachim Pflüger, Dietmar Plenz, Diethelm W. Richter, Silke Sachse, H. Sebastian Seung, Keith T. Sillar, Jeffrey C. Smith, David L. Sparks, D. James Surmeier, Eörs Szathmáry, James M. Tepper, Jeff R. Wickens, Rafael Yuste
Author: Hannsjörg Schröder
Publisher: Springer Nature
ISBN: 3030899802
Category : Medical
Languages : en
Pages : 704
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Book Description
The human brainstem has long been a neglected area in clinical medicine. This is shown by the fact that there is no introductory book on the neuroanatomy and pathology of this region. This book is intended to introduce the reader to the neuroanatomy of the human brainstem and combines an atlas with detailed information on the individual structures. The atlas features a state-of-the-art magnetic resonance imaging series, histological specimens (Darrow Red and Campbell staining) and a plastinate-based topographical part, which allows direct comparison of histological and topographical findings with neuroimaging. In addition, the reader is guided along the brainstem neuromer model through the human brainstem and learns about the functional properties of the individual structures of the brainstem. Where appropriate, peripheral targets of brainstem structures are illustrated and explained. Furthermore, each chapter covers the most important neurological disorders affecting the brainstem. This book aims to demonstrate that sound anatomical knowledge is required to understand brainstem pathology. It will particularly help those new to the field to better understand the complex anatomy of the human brainstem and will be useful to basic and clinical neuroscientists alike.
Author: Gareth Leng
Publisher: MIT Press
ISBN: 0262038056
Category : Science
Languages : en
Pages : 277
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Book Description
How hormonal signals in one small structure of the brain—the hypothalamus—govern our physiology and behavior. As human beings, we prefer to think of ourselves as reasonable. But how much of what we do is really governed by reason? In this book, Gareth Leng considers the extent to which one small structure of the neuroendocrine brain—the hypothalamus—influences what we do, how we love, and who we are. The hypothalamus contains a large variety of neurons. These communicate not only through neurotransmitters, but also through peptide signals that act as hormones within the brain. While neurotransmitter signals tend to be ephemeral and confined by anatomical connectivity, the hormone signals that hypothalamic neurons generate are potent, wide-reaching, and long-lasting. Leng explores the evolutionary origins of these remarkable neurons, and where the receptors for their hormone signals are found in the brain. By asking how the hypothalamic neurons and their receptors are regulated, he explores how the hypothalamus links our passions with our reason. The Heart of the Brain shows in an accessible way how this very small structure is very much at the heart of what makes us human.
Author: Mariska van Sprundel
Publisher: MIT Press
ISBN: 0262365200
Category : Sports & Recreation
Languages : en
Pages : 306
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Book Description
A science writer and recreational runner explores the science behind popularly held beliefs about shoes, injuries, nutrition, "runner's high," and more. Conventional wisdom about running is passed down like folklore (and sometimes contradicts itself): the right kind of shoe prevents injury--or running barefoot, like our prehistoric ancestors, is best; eat a high-fat diet--and also carbo load before a race; running cures depression--but it might be addictive; running can save your life--although it can also destroy your knee cartilage. Often it's hard to know what to believe. In Running Smart, Mariska van Sprundel, a science journalist and recreational runner who has had her fair share of injuries, sets out to explore the science behind such claims. In her quest, van Sprundel reviews the latest developments in sports science, consults with a variety of experts, and visits a sports lab to have her running technique analyzed. She learns, among other things, that according to evolutionary biology, humans are perfectly adapted to running long distances (even if our hunter-gatherer forebears suffered plenty of injuries); that running sets off a shockwave that spreads from foot to head, which may or may not be absorbed by cushioned shoes; and that a good sports bra controls the ping pong-like movements of a female runner's breasts. She explains how the body burns fuel, the best foods to eat before and after running, and what might cause "runner's high." More than fifty million Americans are runners (and a slight majority of them are women). This engaging and enlightening book will help both novice and seasoned runners run their smartest.
Author: Richard Passingham
Publisher: Oxford University Press
ISBN: 0198844573
Category : Medical
Languages : en
Pages : 529
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Book Description
"This chapter explains why this book is organized as it is. Each neocortical area has a unique pattern of inputs and outputs. This means that the challenge is to understand the transformation that each of the prefrontal areas performs from input to output. Functional brain imaging allows us to visualize the human brain at work, but it does not have the spatial resolution to identify the mechanisms that support the transformations that the brain performs. It is neurophysiological recordings from cells that tell us how these are achieved. Chapters 3-8 are therefore mainly devoted to studies that have been carried out on the prefrontal cortex of macaque monkeys because the methods are necessarily invasive. Apart from recording, the methods include making selective lesions in an area; it is these that identify the contribution that is unique to that area. The book ends by reviewing the evolution of the human prefrontal cortex; and the final two chapters discuss the ways in which the human prefrontal cortex is specialized in terms of function. In doing so, they attempt to account for the intellectual gap between humans and other primates"--
Author: Paul W. Glimcher
Publisher: MIT Press
ISBN: 9780262572279
Category : Medical
Languages : en
Pages : 404
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Book Description
In this provocative book, Paul Glimcher argues that economic theory may provide an alternative to the classical Cartesian model of the brain and behavior. Glimcher argues that Cartesian dualism operates from the false premise that the reflex is able to describe behavior in the real world that animals inhabit. A mathematically rich cognitive theory, he claims, could solve the most difficult problems that any environment could present, eliminating the need for dualism by eliminating the need for a reflex theory. Such a mathematically rigorous description of the neural processes that connect sensation and action, he explains, will have its roots in microeconomic theory. Economic theory allows physiologists to define both the optimal course of action that an animal might select and a mathematical route by which that optimal solution can be derived. Glimcher outlines what an economics-based cognitive model might look like and how one would begin to test it empirically. Along the way, he presents a fascinating history of neuroscience. He also discusses related questions about determinism, free will, and the stochastic nature of complex behavior.
