Author: William S. Bullough
Publisher: Elsevier
ISBN: 1483263576
Category : Science
Languages : en
Pages : 214
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Book Description
The Evolution of Differentiation attempts to sketch the outlines of a framework from what is now known or suspected of the various aspects of differentiation in all types of organisms. This book surveys the many aspects of differentiation that are seen today, and in particular, because of the evident universality of expression of the genetic code, to enquire whether any similar universality exists in the methods of gene repression and activation. The information reviewed ranges from the chemical control of the genetic mechanisms of unicellular organisms during their various phases of activity, to the chemical control of differentiation in multicellular organisms both during embryonic development and in the adult state. Finally, some consideration is also given to that collapse of differentiation which leads to cancer.
Author: Michael Brown
Publisher: Cambridge University Press
ISBN: 0521782376
Category : Science
Languages : en
Pages : 550
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Book Description
Summary of recent research covering experimental methods and numerical modelling, for graduate students and researchers.
Author: William Sydney Bullough
Publisher: Academic Press
ISBN: 9780121406509
Category :
Languages : en
Pages : 206
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Book Description
The simplest living organisms: bacteria; Unicellular plants and animals; Tissue and organ formation; Tissue homeastasis: mass and function; Tissue homeostasis: Hormones; Carcinogenesis.
Author: David L. Kirk
Publisher: Cambridge University Press
ISBN: 9780521452076
Category : Science
Languages : en
Pages : 210
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Book Description
This book reviews Volvox development and biology and, through this study, sheds light on the origins of multicellularity.
Author: Richard Gordon
Publisher: World Scientific
ISBN: 9789810222680
Category : Science
Languages : en
Pages : 936
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Book Description
Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.
Author: Matthew D. Herron
Publisher: CRC Press
ISBN: 1000542572
Category : Science
Languages : en
Pages : 395
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Book Description
Among the most important innovations in the history of life is the transition from single-celled organisms to more complex, multicellular organisms. Multicellularity has evolved repeatedly across the tree of life, resulting in the evolution of new kinds of organisms that collectively constitute a significant portion of Earth’s biodiversity and have transformed the biosphere. This volume examines the origins and subsequent evolution of multicellularity, reviewing the types of multicellular groups that exist, their evolutionary relationships, the processes that led to their evolution, and the conceptual frameworks in which their evolution is understood. This important volume is intended to serve as a jumping-off point, stimulating further research by summarizing the topics that students and researchers of the evolution of multicellularity should be familiar with, and highlighting future research directions for the field.
Author: Carsten Berndt
Publisher: CRC Press
ISBN: 1000435385
Category : Science
Languages : en
Pages : 544
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Book Description
Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine. Key Features Provides the first summary on this important topic Reviews redox-dependent development of model organisms and single organs Highlights the redox-regulated pathways important for differentiation processes Illustrates the potential of redox medicine Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration Written by leading experts in the field Related Titles Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1) Clarke, M. & J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4) Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7)
Author: James Badro
Publisher: John Wiley & Sons
ISBN: 1118860578
Category : Science
Languages : en
Pages : 193
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Book Description
The Early Earth: Accretion and Differentiation provides a multidisciplinary overview of the state of the art in understanding the formation and primordial evolution of the Earth. The fundamental structure of the Earth as we know it today was inherited from the initial conditions 4.56 billion years ago as a consequence of planetesimal accretion, large impacts among planetary objects, and planetary-scale differentiation. The evolution of the Earth from a molten ball of metal and magma to the tectonically active, dynamic, habitable planet that we know today is unique among the terrestrial planets, and understanding the earliest processes that led to Earth’s current state is the essence of this volume. Important results have emerged from a wide range of disciplines including cosmochemistry, geochemistry, experimental petrology, experimental and theoretical mineral physics and geodynamics. The topics in this volume include: Condensation of primitive objects in the solar nebula, planetary building blocks Early and late accretion and planetary dynamic modeling Primordial differentiation, core formation, Magma Ocean evolution and crystallization This volume will be a valuable resource for graduate students, academics, and researchers in the fields of geophysics, geochemistry, cosmochemistry, and planetary science.
Author: W. Hennig
Publisher: Springer Science & Business Media
ISBN: 3540398384
Category : Science
Languages : en
Pages : 206
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Book Description
One of the oldest problems in developmental biology is the differentiation between germ line and somatic cells. The continuity of germ line cells between subsequent generations of multicellular organisms was first suggested by Owen, and later elaborated by A. Weismann to his famous germ line theory. His additional assumption that cellular differentiation was based on a differential representation of the genetic material in somatic cells was soon disproved. In some, apparently exceptional, cases, however, such differences in the genetic material between germ line and somatic cells were discovered. The best-known example is the nematod Ascaris. Boveri discovered and studied the fundamental differences in the karyotypes of germ line and soma of Parascaris equorum. Later, similar situations were found in some other organisms. However, in particular the work ofSpemann demonstrated that cellular differentiation in general is not accompanied by fundamental changes of the genetic material. Subsequently, the relatively few examples of germ line-soma differences achieved by chromatin elimination processes have been considered as a curiosity. Experimental studies have been essentially restricted to Ascaris species and to the pioneering cytological studies of chromatin elimination by S. Beermann. Despite the large proportions of the genome involved in chromatin elimina tion, our knowledge of this process is still very restricted. In particular the biological meaning of this differentiation process is entirely obscure. In this context one must, however, consider that also for the majority of DNA sequences in eukaryotic genomes the biological relevance is unclear.
Author: A.R. Bellve
Publisher: Academic Press
ISBN: 0323152732
Category : Science
Languages : en
Pages : 388
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Book Description
Molecular Mechanisms in Cellular Growth and Differentiation describes the cellular differentiation and development. It emphasizes the pattern formation, specifically the genesis of spatial relationships, among the parts of a vertebrate or invertebrate organism, embryonic or adult. Organized into five parts, this book deals with the major steps leading from growth factor-receptor interactions, through transduction and modulation mechanisms, to proliferative response. It also discusses the relation of growth factors and their receptors to oncogenes and to protooncogenes. It also elucidates the roles of growth factors and receptors in cell differentiation and development, particularly, in pattern formation. The homeotic systems regulated intracellularly and the two differentiation systems thought to involve sequence-specific DNA-binding proteins in conjunction with small molecules are also explored.
