The Elusive Magic Bullet PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Elusive Magic Bullet PDF full book. Access full book title The Elusive Magic Bullet by J. Mann. Download full books in PDF and EPUB format.
Author: J. Mann
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 234
Get Book Here
Book Description
In his exciting new book, John Mann, author of the highly successful Murder, Magic, and Medicine, reveals the history of the drugs that are so commonplace today in the treatment of disease. While we can now treat so many of these illnesses, the side-effects caused by many of these treatmentscan be severe, and even more worrying - the bacteria are now becoming more resistant to the drugs (the so-called 'superbugs'). Scientists are also faced with a massive challenge in developing drugs that can effectively treat HIV, ebola, and many forms of cancer, but without the terribleside-effects of such treatments as chemotherapy or AZT - this is the quest for the 'magic bullet.' The book starts with a history of drug development, introducing us to some of the fascinating characters whose work so influenced the search for these drugs. Leading up to the present day, and theexciting advances being made within molecular biology, the book provides a lively, and fascinating introduction for non-scientists to one of the most exciting fields of activity within modern medicine.
Author: J. Mann
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 234
Get Book Here
Book Description
In his exciting new book, John Mann, author of the highly successful Murder, Magic, and Medicine, reveals the history of the drugs that are so commonplace today in the treatment of disease. While we can now treat so many of these illnesses, the side-effects caused by many of these treatmentscan be severe, and even more worrying - the bacteria are now becoming more resistant to the drugs (the so-called 'superbugs'). Scientists are also faced with a massive challenge in developing drugs that can effectively treat HIV, ebola, and many forms of cancer, but without the terribleside-effects of such treatments as chemotherapy or AZT - this is the quest for the 'magic bullet.' The book starts with a history of drug development, introducing us to some of the fascinating characters whose work so influenced the search for these drugs. Leading up to the present day, and theexciting advances being made within molecular biology, the book provides a lively, and fascinating introduction for non-scientists to one of the most exciting fields of activity within modern medicine.
Author: Sebastian G. B. Amyes
Publisher: CRC Press
ISBN: 142002468X
Category : Medical
Languages : en
Pages : 273
Get Book Here
Book Description
Author: P. Day
Publisher: Oxford University Press, USA
ISBN: 0198500858
Category : Science
Languages : en
Pages : 235
Get Book Here
Book Description
Much of our present knowledge of the universe has come from observations made over the centuries with ever more powerful telescopes, operating from isolated mountain tops. But the Hubble Space Telescope, the first to be launched into space, is revolutionizing our ability to picture and understand the universe. In Exploring the Universe, astronomer Alexander Boksenberg shows how a star is born and how the magnificent pictures taken by the Hubble Space Telescope will enable us to explore the universe in ever more depth. This selection of essays from experts in their fields - exploring subjects from magic bullets derived from traditional folk medicines, to the role science can play in understanding the work of Mondrian and other artists - taken from the Royal Institution's Evening Discourses provides an authoritative and accessible summary of current thinking in many areas of science and technology.
Author: Lara V. Marks
Publisher: Yale University Press
ISBN: 0300213522
Category : Medical
Languages : en
Pages : 345
Get Book Here
Book Description
This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. Discovered in the mid-1970s in the laboratory where Watson and Crick had earlier unveiled the structure of DNA, Mabs have radically changed understandings of the pathways of disease. They have enabled faster, cheaper, and more accurate clinical diagnostic testing on a vast scale. And they have played a fundamental role in pharmaceutical innovation, leading to such developments as recombinant interferon and insulin, and personalized drug therapies such as Herceptin. Today Mabs constitute six of the world’s top ten blockbuster drugs and make up a third of new introduced treatments. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs whose persistence and creativity ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, as Marks shows, controversies over Mabs remain, and she examines current debates over the costs and effectiveness of these innovative drugs.
Author: Matthew Oram
Publisher: JHU Press
ISBN: 1421426218
Category : Medical
Languages : en
Pages : 430
Get Book Here
Book Description
The rise—and fall—of research into the therapeutic potential of LSD. After LSD arrived in the United States in 1949, the drug's therapeutic promise quickly captured the interests of psychiatrists. In the decade that followed, modern psychopharmacology was born and research into the drug's perceptual and psychological effects boomed. By the early 1960s, psychiatrists focused on a particularly promising treatment known as psychedelic therapy: a single, carefully guided, high-dose LSD session coupled with brief but intensive psychotherapy. Researchers reported an astounding 50 percent success rate in treating chronic alcoholism, as well as substantial improvement in patients suffering from a range of other disorders. Yet despite this success, LSD officially remained an experimental drug only. Research into its effects, psychological and otherwise, dwindled before coming to a close in the 1970s. In The Trials of Psychedelic Therapy, Matthew Oram traces the early promise and eventual demise of LSD psychotherapy in the United States. While the common perception is that LSD's prohibition terminated legitimate research, Oram draws on files from the Food and Drug Administration and the personal papers of LSD researchers to reveal that the most significant issue was not the drug's illegality, but the persistent question of its efficacy. The landmark Kefauver-Harris Drug Amendments of 1962 installed strict standards for efficacy evaluation, which LSD researchers struggled to meet due to the unorthodox nature of their treatment. Exploring the complex interactions between clinical science, regulation, and therapeutics in American medicine, The Trials of Psychedelic Therapy explains how an age of empirical research and limited government oversight gave way to sophisticated controlled clinical trials and complex federal regulations. Analyzing the debates around how to understand and evaluate treatment efficacy, this book will appeal to anyone with an interest in LSD and psychedelics, as well as mental health professionals, regulators, and scholars of the history of psychiatry, psychotherapy, drug regulation, and pharmaceutical research and development.
Author: Steven B. Mertens
Publisher: IAP
ISBN: 1607524910
Category : Education
Languages : en
Pages : 434
Get Book Here
Book Description
The Encyclopedia of Middle Grades Education provides a comprehensive overview of the field. This publication includes seven anchor essays (5000 words) that cover the following topics: the history of the middle school movement; academically excellent curriculum, instruction, and assessment; developmental responsiveness in relation to young adolescents; social equity in middle grades schools; leadership in middle level schools; teacher and administrator preparation and professional development; and future directions in relation to the movement, practices, and policy. Leading scholars in the field of middle grades education were invited to author these essays. In addition to the seven anchor essays, the encyclopedia contains alphabetically organized entries (short entries approximately 500 words; long entries approximately 2000 words) that address important concepts, ideas, terms, people, organizations, and seminal publications related to middle grades education. Contributors to the encyclopedia have provided sufficient information so that the reader can place the idea, concept, person, etc. into its proper context in the history of the middle school movement. Entries are meant to be introductory; after an overview of the essentials of the topic the reader is guided to more extensive sources for further investigation. Where appropriate, the reader is also directed to electronic sources such as websites where additional information can be retrieved.
Author: J. J. Dongarra
Publisher: SIAM
ISBN: 9780898713435
Category : Reference
Languages : en
Pages : 310
Get Book Here
Book Description
The editors provide a review of the programming environments for parallel computers with the help of worldwide specialists in each domain. Four different domains were discussed at the workshop, and they each form a part of this book.
Author: Laura Bowater
Publisher: Royal Society of Chemistry
ISBN: 1788014111
Category : Medical
Languages : en
Pages : 200
Get Book Here
Book Description
Antibiotics are familiar drugs to us all, so familiar that we may take them for granted. They allow us to survive life-threatening infections, and allow us to protect the animals we farm for food. Many antibiotics have now become ineffective against common diseases, and there are few alternative treatments to replace them. In this topical popular science book, Laura Bowater, Professor of Microbiology Education and Engagement at Norwich Medical School, considers the past, present and uncertain future of antibiotics. This book begins by looking back at how infectious diseases, such as smallpox and the plague, were able to wreak havoc on populations before the discovery of the first antibiotics. These then revolutionised the medical world. In an engaging and accessible style, Professor Bowater takes the reader through how antibiotics are made, how bacteria are able to mutate and develop resistance and she explains why there is now a lack of new antibiotic drugs coming to market. What will a future of continued antibiotic resistance look like? How can human activities prevent the rise of ‘superbugs'? Professor Bowater highlights the need for universal cooperation in order to tackle this global health challenge, which, if not addressed, could transport us back to the medical dark ages.
Author: Katherine Boothe
Publisher: University of Toronto Press
ISBN: 1442617381
Category : Health & Fitness
Languages : en
Pages : 232
Get Book Here
Book Description
Canada is the only OECD country that has universal, comprehensive public hospital and medical insurance but lacks equivalent pharmaceutical coverage. In Ideas and the Pace of Change, Katherine Boothe explains the reasons for this unique situation. Using archival, interview, and polling data, Boothe compares the policy histories of Canada, the United Kingdom, and Australia in order to understand why Canada followed a different path on pharmaceutical insurance. Boothe argues that pace matters in policy change. Quick, radical change requires centralized political institutions, an elite consensus, and an engaged, attentive electorate. Without these prerequisites, states are far more likely to take a slower, incremental approach. But while rapid policy change reinforces the new consensus, incremental progress strengthens the status quo, letting development stall and raising the bar for achieving change. An important contribution to the study of comparative political economy, Ideas and the Pace of Change should be required reading for anyone seeking to understand why health care reforms succeed or fail.
Author: Yasuhiro Matsumura
Publisher: Springer Nature
ISBN: 4431568808
Category : Medical
Languages : en
Pages : 325
Get Book Here
Book Description
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.
