The Development of Exfoliative Cytology as a Technique for the Early Detection of Cancer PDF Download
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Author: Guillermo Terzano
Publisher:
ISBN:
Category :
Languages : en
Pages : 6
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Book Description
Author: Guillermo Terzano
Publisher:
ISBN:
Category :
Languages : en
Pages : 6
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Book Description
Author: World Health Organization. Regional Office for Europe
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 52
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Book Description
Author: Hywel Williams
Publisher: John Wiley & Sons
ISBN: 9781444300178
Category : Medical
Languages : en
Pages : 740
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Book Description
Evidence-based Dermatology, Second Edition is aunique book in the field of clinical dermatology. Written andedited by some of the world’s leading experts inevidence-based dermatology, it takes a highly evidence-basedapproach to the treatment of all major and many of the less commonskin conditions. The toolbox at the beginning of the book explaining how tocritically appraise different studies, along with the comprehensivereviewing and appraisal of evidence in the clinical chapters makesthis book distinctive in its field as do the treatmentrecommendations which are based on the discussion of the bestavailable evidence using a question-driven approach and a commonstructure on dealing with efficacy, drawbacks and implications forclinical practice.
Author: Shannon Elise Weigum
Publisher:
ISBN:
Category :
Languages : en
Pages : 300
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Book Description
Oral cancer is the sixth most common cancer worldwide and has been marked by high morbidity and poor survival rates that have changed little over the past few decades. Beyond prevention, early detection is the most crucial determinant for successful treatment and survival of cancer. Yet current methodologies for cancer diagnosis based upon pathological examination alone are insufficient for detecting early tumor progression and molecular transformation. Development of new diagnostic tools incorporating tumor biomarkers could enhance early detection by providing molecular-level insight into the biochemical and cellular changes associated with oral carcinogenesis. The work presented in this doctoral dissertation aims to address this clinical need through the development of new automated cellular analysis methods, incorporating lab-on-a-chip sensor techniques, for examination of molecular and morphological biomarkers associated with oral carcinogenesis. Using the epidermal growth factor receptor (EGFR) as a proof-of-principle biomarker, the sensor system demonstrated capacity to support rapid biomarker analysis in less than one-tenth the time of traditional methods and effectively characterized EGFR biomarker over-expression in oral tumor-derived cell lines. Successful extension from in vitro tumor cell lines to clinically relevant exfoliative brush cytology was demonstrated, providing a non-invasive method for sampling abnormal oral epithelium. Incorporation of exfoliative cytology further helped to define the important assay and imaging parameters necessary for dual molecular and morphological analysis in adherent epithelium. Next, this new sensor assay and method was applied in a small pilot study in order to secure an initial understanding of the diagnostic utility of such biosensor systems in clinical settings. Four cellular features were identified as useful indicators of cancerous or pre-cancerous conditions including, the nuclear area and diameter, nuclear-to-cytoplasm ratio, and EGFR biomarker expression. Further examination using linear regression and ROC curve analysis identified the morphological features as the best predictors of disease while a combination of all features may be ideal for classification of OSCC and pre-malignancy with high sensitivity and specificity. Further testing in a larger sample size is necessary to validate this regression model and the LOC sensor technique, but shows strong promise as a new diagnostic tool for early detection of oral cancer.
Author: Alecsandru Ioan Baba
Publisher:
ISBN: 9789732714577
Category : Electronic books
Languages : en
Pages : 787
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Book Description
Author: Sudha R. Kini
Publisher: Lippincott Williams & Wilkins
ISBN: 1451153686
Category : Medical
Languages : en
Pages : 1040
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Book Description
The primary thrust of this atlas is a comparison between different diagnostic entities with cytologic findings summarized in tabulated forms. The book contains over 3,200 full color photographs that illustrate the criteria for the cytology described. The Color Atlas of Differential Diagnosis in Exfoliative and Aspiration Cytopathology is an excellent reference for everyday use when difficult and challenging cases face both cytotechnologists and pathologists. A tabulated form of information saves valuable time while reporting cytopathology.
Author: Svante R. Orell
Publisher: Elsevier India
ISBN: 813123116X
Category : Medical
Languages : en
Pages : 17
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Book Description
Orell & Sterrett's Fine Needle Aspiration Cytology 5e provides you with a logical and systematic approach to the acquisition, interpretation and diagnosis of FNA biopsy samples. It is an ideal resource for all those requiring an authoritative and systematic review of the cytological findings in those malignant and benign lesions likely to be the target of FNA. The book is lavishly illustrated with high quality colour images that demonstrate the cytological features as well as their relevant immunohistochemical and molecular findings. Organized into anatomical regions, each chapter is consistently organized into two parts: the first deals with clinical and technical aspects followed by a systematic presentation of cytological findings. This is your perfect practical bench resource for daily reference in the laboratory. Provides practical tips and advice on how to avoid pitfalls and ensure accurate diagnoses. Over 1,200 colour illustrations capture each entity's cellular, morphological and immunohistochemical appearance. Chapters have been up-dated and revised and a brand new one on cytological findings in infectious diseases added. Both MGG and Pap smears illustrated in parallel as well as the corresponding histology to help provide side-by-side analysis. Access the full text online and download images via Expert Consult.
Author: Ravi Mehrotra
Publisher: Springer Science & Business Media
ISBN: 146145221X
Category : Medical
Languages : en
Pages : 184
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Book Description
Oral Cytology: A Concise Guide provides a state-of-the-art review of the major issues specific to the field of oral cytology. The sections of the book have been structured to review the complexities of sample collection, manual/automated analysis, pitfalls, gray zones and controversies in diagnosis, as well as, issues not covered by other available materials. Recent advancements in ancillary techniques like DNA ploidy, image analysis and molecular biology are discussed in detail. This useful text is extensively illustrated with patient and microscopic pictures, which will further highlight the clinical application. Throughout the text, simultaneous inclusion of both cytologic and histologic images will allow cyto-histological correlation. Readers will find descriptions of techniques offering greater simplicity, speed, patient comfort and cost effectiveness, as well as improved diagnostic precision. This bench-side reference is a unique and valuable resource in the field of oral cytology, both for those currently in training and clinicians dealing with the diagnosis of oral lesions.
Author: M.M. Bui
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318065765
Category : Medical
Languages : en
Pages : 120
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Book Description
In the era of precision medicine, physicians are increasingly in need of more definitive diagnostic, prognostic, and predictive information derived from small biopsy specimens such as cytology samples in order to guide effective patient care. Cytopathology is well poised to meet this challenge. Whilst the traditional cytomorphologic component of cytology practice is still valid, enormous advances have been made in the field of cytopathology thanks to transformative technology and innovative individuals that have augmented the cytologists' ability to meet the demands of modern medicine. The purpose of this book is to describe, illustrate, and review many of the most recent developments regarding modern techniques employed in cytopathology. This latest monograph is intended for all cytologists including cytopathologists, cytotechnologists, cytology lab assistants, trainees, research scientists, and anyone who is interested in the field of cytopathology. We have invited pioneering experts in their respective fields to author these chapters. This book is not only the culmination of their groundbreaking work and effort but also presents a critical review of the current literature. We have attempted to provide readers with an informative and comprehensive aid so that they may better appreciate how emerging technology has been applied to cytology. Each chapter in this book presents a stand-alone contemporary review of emerging topics in cytopathology. We hope that you will find this monograph thought-provoking and a valuable reference for your practice.
Author: Gokul Sridharan
Publisher: BoD – Books on Demand
ISBN: 1838805028
Category : Medical
Languages : en
Pages : 246
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Book Description
Oral diseases are one of the more common non-communicable health diseases. They pose a major health burden for many countries and affect people throughout their lifetime causing pain, discomfort, disfigurement, and even death. As per WHO, it is estimated that oral diseases affect nearly 3.5 billion people globally. In developing countries, the estimate could be still higher owing to the lack of awareness among the general public, the lack of adequate infrastructure, and less accessibility to oral health care providers, especially amongst people of lower socio-economic status. The aim of this book is to provide an overview of various oral diseases with emphasis on the pathogenesis, investigation, and the management protocol of different oral and maxillofacial diseases.
