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Author: Charles Bukowski
Publisher: Harper Collins
ISBN: 006177121X
Category : Poetry
Languages : en
Pages : 146
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Book Description
In the literary pantheon, Charles Bukowski remains a counterculture luminary. A hard-drinking wild man of literature and a stubborn outsider to the poetry world, he has struck a chord with generations of readers, writing raw, tough poetry about booze, work, and women in an authentic voice that is, like the work of the Beats, iconoclastic and even dangerous. Edited by his longtime publisher, John Martin, of Black Sparrow Press, and now in paperback, The Continual Condition includes more of this legend’s never-before-collected poems.
Author: Charles Bukowski
Publisher: Harper Collins
ISBN: 006177121X
Category : Poetry
Languages : en
Pages : 146
Get Book Here
Book Description
In the literary pantheon, Charles Bukowski remains a counterculture luminary. A hard-drinking wild man of literature and a stubborn outsider to the poetry world, he has struck a chord with generations of readers, writing raw, tough poetry about booze, work, and women in an authentic voice that is, like the work of the Beats, iconoclastic and even dangerous. Edited by his longtime publisher, John Martin, of Black Sparrow Press, and now in paperback, The Continual Condition includes more of this legend’s never-before-collected poems.
Author: Charles Bukowski
Publisher: Harper Collins
ISBN: 006177121X
Category : Poetry
Languages : en
Pages : 146
Get Book Here
Book Description
In the literary pantheon, Charles Bukowski remains a counterculture luminary. A hard-drinking wild man of literature and a stubborn outsider to the poetry world, he has struck a chord with generations of readers, writing raw, tough poetry about booze, work, and women in an authentic voice that is, like the work of the Beats, iconoclastic and even dangerous. Edited by his longtime publisher, John Martin, of Black Sparrow Press, and now in paperback, The Continual Condition includes more of this legend’s never-before-collected poems.
Author: Jan Karon
Publisher: Penguin
ISBN: 1101200995
Category : Fiction
Languages : en
Pages : 194
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Book Description
From Jan Karon, the #1 New York Times bestselling author of the Mitford series comes a collection of Father Tim's favorite words of wisdom and spiritual inspiration... For years, Mitford’s Father Tim Kavanagh has transcribed into his dog-eared journals words of wisdom, faith, and encouragement. Written in his own hand or typed on his idiosyncratic Royal typewriter, A Continual Feast contains the lively ideas, common sense, profound wisdom, and plain good humor he has gleaned from the likes of C. S. Lewis, Emily Dickinson, William Blake, Helen Keller, G. K. Chesterton, and Will Rogers, to name just a few. Together with its successful companion volume, Patches of Godlight, Father Tim’s latest quote journal is sure proof of the truth of an entry from Lord Byron: "A small drop of ink produces that which makes thousands think." This entertaining and useful handbook is for all those who relish a good “Aha!,” including authors, clergy, speechmakers, dog lovers, and anyone who enjoys provocative insight into everything from the righteous to the ridiculous.
Author: Janet R. Gilsdorf
Publisher:
ISBN: 0190677317
Category : Medical
Languages : en
Pages : 265
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Book Description
Not all scientific discoveries are genius. Continual Raving tells the combined stories of how scientists across the 19th and 20th centuries defeated meningitis -- not through flawless scientific research, but often through a series of serendipitous events, misplaced assumptions, and flawed conclusions. The result is a story of not just a vanquished disease, but how scientific accomplishment sometimes occurs where it's least expected. Although symptoms of meningitis were recorded as early as Hippocrates and the ancient Greeks, our understanding of the disease's origins and mechanisms remained obscure for most of human history. That changed in 1892, when German physician Richard Pfeiffer observed and isolated bacteria ultimately shown to cause meningitis in children -- and concluded that those bacteria cause influenza. Haemophilus influenzae, as thee meningitis-causing bacteria have been erroneously named ever since, continued their strange journey to discovery in the decades that followed. Continual Raving traces the disease's strange encounters with science, including: - Heinrich Quincke, the German internist who first used a needle to draw spinal fluid from between a patient's back bones - Simon Flexner's management of American meningitis epidemics using immune serum from a horse - American bacteriologist Margaret Pittman's discovery (during the Great Depression, no less) of a sugar overcoat that protects the bacteria from white blood cells - Pediatrician Ashley Weech, who gave the first antibiotic used in America (based on instructions written in German) to a young patient sick with meningitis - Microbiologist Hattie Alexander, who learned why these antibiotics sometimes fail in such patients - Four scientists, in two teams, as they vied to be the first to create the right vaccine to prevent meningitis in infants In each of these deeply human stories, variables of chance, circumstance, and incorrect assumptions intervene to shape not just the arc of the scientists' lives, but the trajectory of how humans have come to understand one of our most pernicious diseases. Continual Raving is a mosaic tale of how science conquered meningitis -- and a larger story of the sometimes winding road to discovery.
Author: Ying Kuen Cheung
Publisher: CRC Press
ISBN: 1420091514
Category : Mathematics
Languages : en
Pages : 207
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Book Description
As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. A self-contained theoretical framework of the CRM for researchers and graduate students who set out to learn and do research in the CRM and dose-finding methods in general, Dose Finding by the Continual Reassessment Method features: Real clinical trial examples that illustrate the methods and techniques throughout the book Detailed calibration techniques that enable biostatisticians to design a CRM in timely manner Limitations of the CRM are outlined to aid in correct use of method This book supplies practical, efficient dose-finding methods based on cutting edge statistical research. More than just a cookbook, it provides full, unified coverage of the CRM in addition to step-by-step guidelines to automation and parameterization of the methods used on a regular basis. A detailed exposition of the calibration of the CRM for applied statisticians working with dose-finding in phase I trials, the book focuses on the R package ‘dfcrm’ for the CRM and its major variants. The author recognizes clinicians’ skepticism of model-based designs, and addresses their concerns that the time, professional, and computational resources necessary for accurate model-based designs can be major bottlenecks to the widespread use of appropriate dose-finding methods in phase I practice. The theoretically- and empirically-based methods in Dose Finding by the Continual Reassessment Method will lessen the statistician’s burden and encourage the continuing development and implementation of model-based dose-finding methods.
Author: H A Ironside
Publisher:
ISBN: 9781258261313
Category :
Languages : en
Pages : 374
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Book Description
Author: James Bird
Publisher: Feiwel & Friends
ISBN: 1250247748
Category : Juvenile Fiction
Languages : en
Pages : 268
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Book Description
Perfect for fans of Rain Reign, this middle-grade novel The Brave is about a boy with an undiagnosed anxiety issue and his move to a reservation to live with his biological mother. Collin can't help himself—he has a mental health condition that finds him counting every letter spoken to him. It's a quirk that makes him a prime target for bullies, and frustrates the adults around him, including his father. When Collin asked to leave yet another school, his dad decides to send him to live in Minnesota with the mother he's never met. She is Ojibwe, and lives on a reservation. Collin arrives in Duluth with his loyal dog, Seven, and quickly finds his mom and his new home to be warm, welcoming, and accepting of his disability. Collin’s quirk is matched by that of his neighbor, Orenda, a girl who lives mostly in her treehouse and believes she is turning into a butterfly. With Orenda’s help, Collin works hard to learn the best ways to manage his anxiety disorder. His real test comes when he must step up for his new friend and trust his new family.
Author: Howard Sounes
Publisher: Open Road + Grove/Atlantic
ISBN: 0802199305
Category : Biography & Autobiography
Languages : en
Pages : 356
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Book Description
“A lively portrait of American literature’s ‘Dirty Old Man’.” —Library Journal A former postman and long-term alcoholic who did not become a full-time writer until middle age, Charles Bukowski was the author of autobiographical novels that captured the low life—including Post Office, Factotum, and Women—and made him a literary celebrity, with a major Hollywood film (Barfly) based on his life. Drawing on new interviews with virtually all of Bukowski’s friends, family, and many lovers; unprecedented access to his private letters and unpublished writing; and commentary from Norman Mailer, Allen Ginsberg, Sean Penn, Mickey Rourke, Lawrence Ferlinghetti, R. Crumb, and Harry Dean Stanton, Howard Sounes has uncovered the extraordinary true story of the Dirty Old Man of American literature. Illustrated with drawings by Bukowski and over sixty photographs, Charles Bukowski is a must for Bukowski devotees and new readers alike. “Bukowski is one of those writers people remember more for the legend than for the work . . . but, as Howard Sounes shows in this exhaustively researched biography, it wasn’t the whole story.” —Los Angeles Times “Engaging . . . Adroit . . . revealing.” —The New York Times Book Review “A must-read for anybody who is a fan of Bukowski’s writing.” —The Globe and Mail (Toronto)
Author: Charles Bukowski
Publisher: Harper Collins
ISBN: 0061851914
Category : Fiction
Languages : en
Pages : 265
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Book Description
“Wordsworth, Whitman, William Carlos Williams, and the Beats in their respective generations moved poetry toward a more natural language. Bukowski moved it a little farther.” –Los Angeles Times Book Review In what is widely hailed as the best of his many novels, Charles Bukowski details the long, lonely years of his own hardscrabble youth in the raw voice of alter ego Henry Chinaski. From a harrowingly cheerless childhood in Germany through acne-riddled high school years and his adolescent discoveries of alcohol, woman, and the Los Angeles Public Library's collection of D.H. Lawrence, Ham on Rye offers a crude, brutal, and savagely funny portrait of an outcast's coming-of-age during the desperate days of the Great Depression.
Author: Bill W.
Publisher: Penguin
ISBN: 0698176936
Category : Self-Help
Languages : en
Pages : 418
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Book Description
A 75th anniversary e-book version of the most important and practical self-help book ever written, Alcoholics Anonymous. Here is a special deluxe edition of a book that has changed millions of lives and launched the modern recovery movement: Alcoholics Anonymous. This edition not only reproduces the original 1939 text of Alcoholics Anonymous, but as a special bonus features the complete 1941 Saturday Evening Post article “Alcoholics Anonymous” by journalist Jack Alexander, which, at the time, did as much as the book itself to introduce millions of seekers to AA’s program. Alcoholics Anonymous has touched and transformed myriad lives, and finally appears in a volume that honors its posterity and impact.
