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Author: Barry A. Bunin
Publisher: Elsevier
ISBN: 0080542409
Category : Science
Languages : en
Pages : 341
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Book Description
With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods Serves as a laboratory manual for bench chemists Includes a chapter on linkers to assist in choice of linking strategy Discusses strengths and limitations of the various methods Contains a structural index showing functional group transformations in solid-phase synthesis
Author: Barry A. Bunin
Publisher: Elsevier
ISBN: 0080542409
Category : Science
Languages : en
Pages : 341
Get Book
Book Description
With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods Serves as a laboratory manual for bench chemists Includes a chapter on linkers to assist in choice of linking strategy Discusses strengths and limitations of the various methods Contains a structural index showing functional group transformations in solid-phase synthesis
Author: K. C. Nicolaou
Publisher: Wiley-VCH
ISBN:
Category : Medical
Languages : en
Pages : 652
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Book Description
In two volumes, this comprehensive handbook provides coverage of the whole area of combinatorial synthetic chemistry, including compound library design and synthesis.
Author: Nicholas K. Terrett
Publisher:
ISBN: 9780198502197
Category : Combinatorial chemistry
Languages : en
Pages : 204
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Book Description
Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.
Author: Barry A. Bunin
Publisher:
ISBN: 9780121413453
Category :
Languages : en
Pages :
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Book Description
Author: Ian P. Goulden
Publisher: Courier Corporation
ISBN: 0486435970
Category : Mathematics
Languages : en
Pages : 609
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Book Description
This graduate-level text presents mathematical theory and problem-solving techniques associated with enumeration problems. Subjects include the combinatorics of the ordinary generating function and the exponential generating function, the combinatorics of sequences, and the combinatorics of paths. The text is complemented by approximately 350 exercises with full solutions. 1983 edition. Foreword by Gian-Carlo Rota. References. Index.
Author: Donald L. Kreher
Publisher: CRC Press
ISBN: 1000141373
Category : Computers
Languages : en
Pages : 346
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Book Description
This textbook thoroughly outlines combinatorial algorithms for generation, enumeration, and search. Topics include backtracking and heuristic search methods applied to various combinatorial structures, such as: Combinations Permutations Graphs Designs Many classical areas are covered as well as new research topics not included in most existing texts, such as: Group algorithms Graph isomorphism Hill-climbing Heuristic search algorithms This work serves as an exceptional textbook for a modern course in combinatorial algorithms, providing a unified and focused collection of recent topics of interest in the area. The authors, synthesizing material that can only be found scattered through many different sources, introduce the most important combinatorial algorithmic techniques - thus creating an accessible, comprehensive text that students of mathematics, electrical engineering, and computer science can understand without needing a prior course on combinatorics.
Author: Michael Henle
Publisher: Courier Corporation
ISBN: 9780486679662
Category : Mathematics
Languages : en
Pages : 340
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Book Description
Excellent text covers vector fields, plane homology and the Jordan Curve Theorem, surfaces, homology of complexes, more. Problems and exercises. Some knowledge of differential equations and multivariate calculus required.Bibliography. 1979 edition.
Author: Lisa B. English
Publisher: Springer Science & Business Media
ISBN: 1592592856
Category : Science
Languages : en
Pages : 380
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Book Description
The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.
Author: Matthias Beck
Publisher: American Mathematical Soc.
ISBN: 147042200X
Category : Combinatorial analysis
Languages : en
Pages : 308
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Book Description
Combinatorial reciprocity is a very interesting phenomenon, which can be described as follows: A polynomial, whose values at positive integers count combinatorial objects of some sort, may give the number of combinatorial objects of a different sort when evaluated at negative integers (and suitably normalized). Such combinatorial reciprocity theorems occur in connections with graphs, partially ordered sets, polyhedra, and more. Using the combinatorial reciprocity theorems as a leitmotif, this book unfolds central ideas and techniques in enumerative and geometric combinatorics. Written in a friendly writing style, this is an accessible graduate textbook with almost 300 exercises, numerous illustrations, and pointers to the research literature. Topics include concise introductions to partially ordered sets, polyhedral geometry, and rational generating functions, followed by highly original chapters on subdivisions, geometric realizations of partially ordered sets, and hyperplane arrangements.
Author: Philippe Flajolet
Publisher: Cambridge University Press
ISBN: 1139477161
Category : Mathematics
Languages : en
Pages : 825
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Book Description
Analytic combinatorics aims to enable precise quantitative predictions of the properties of large combinatorial structures. The theory has emerged over recent decades as essential both for the analysis of algorithms and for the study of scientific models in many disciplines, including probability theory, statistical physics, computational biology, and information theory. With a careful combination of symbolic enumeration methods and complex analysis, drawing heavily on generating functions, results of sweeping generality emerge that can be applied in particular to fundamental structures such as permutations, sequences, strings, walks, paths, trees, graphs and maps. This account is the definitive treatment of the topic. The authors give full coverage of the underlying mathematics and a thorough treatment of both classical and modern applications of the theory. The text is complemented with exercises, examples, appendices and notes to aid understanding. The book can be used for an advanced undergraduate or a graduate course, or for self-study.
