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Author: Ben Slavic
Publisher:
ISBN: 9789490824174
Category :
Languages : en
Pages :
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Book Description
Author: Ben Slavic
Publisher:
ISBN: 9789490824174
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: David DeBatto
Publisher: Grand Central Publishing
ISBN: 0446510629
Category : Fiction
Languages : en
Pages : 267
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Book Description
In a story so explosive that he can only tell it as fiction, former counterintelligence special agent David DeBatto takes us onto a new kind of battlefield, beyond the reach of reporters, and into the covert ops of elite tactical intelligence teams. Their number one job: to pierce the secrets of an enemy -- before the enemy reaches us . . . Staff Sgt. David DeLuca had a love/hate relationship with the Armed Forces. Then came 9/11. After a career as a street cop, he went to war-and put his skills to work in a secret army within an army. Part detective, con man, spy, and soldier, DeLuca is now hunting a Saddam loyalist Centcom thought was dead. To catch his prey, he'll have to outmaneuver him using microscopic forensic evidence, high-tech espionage tools, and gut instincts. But as he follows a deadly trail out of the Sunni Triangle into Iran, a horrifying picture is coming clear to DeLuca and his elite "red" team: a terrorist group already has its fangs in the USA -- and needs to be hunted down and eliminated right now . . .
Author: Christopher Lynch
Publisher: Dog Ear Publishing
ISBN: 9781608447398
Category : Intelligence officers
Languages : en
Pages : 0
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Book Description
Fans of "The Americans" TV series on the FX Network will recognize elements of the show in The CI Desk, Chris Lynch's account of his thirty years as a counterintelligence analyst at the FBI and CIA. "The Americans" creator Joe Weisberg discovered the now-popular "character," the "FBI mail robot," within The CI Desk's pages, and hired Chris Lynch to be a consultant for the show. Since then, the Writers Guild of America and Peabody Award-winning writers of the show have extracted anecdotes, descriptions, and terms from The CI Desk for episodes of "The Americans," including "The Bureau does not feel," "munchkins," and Lynch's own experience of being suddenly and inexplicably summoned to the Director's office. According to Kim Chamberlain of EspionageMagazine.com, "this book lends the personality, depth, and reality to the day-to-day intelligence that seems to be lacking in other works. With a razor-sharp wit, a keen eye for human nature, and a wry sense of humor, The CI Desk is in turn hilarious and saddening. There are some nail-biter moments here (and) a seemingly endless procession of fascinating characters," including moles (such as FBI agent Robert P. Hansson, Lynch's supervisor for two years), mole hunters, penetrations of hostile services, defectors, agent handlers, and the unsung people at headquarters desks in FBI and CIA operations that spanned the globe. The C.I. Desk shows the routine, the thrilling, and the sometimes funny or tragic human side of the counterintelligence work of the FBI and CIA.
Author: Jiwei Ci
Publisher: Harvard University Press
ISBN: 0674238184
Category : Political Science
Languages : en
Pages : 433
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Book Description
A respected Chinese political philosopher calls for the Communist Party to take the lead in moving China along the path to democracy before it is too late. With Xi Jinping potentially set as president for life, China’s move toward political democracy may appear stalled. But Jiwei Ci argues that four decades of reform have created a mentality in the Chinese people that is just waiting for the political system to catch up, resulting in a disjunction between popular expectations and political realities. The inherent tensions in a largely democratic society without a democratic political system will trigger an unprecedented crisis of legitimacy, forcing the Communist Party to act or die. Two crises loom for the government. First is the waning of the Communist Party’s revolutionary legacy, which the party itself sees as a grave threat. Second is the fragility of the next leadership transition. No amount of economic success will compensate for the party’s legitimacy deficit when the time comes. The only effective response, Ci argues, will be an orderly transition to democracy. To that end, the Chinese government needs to start priming its citizens for democracy, preparing them for new civil rights and civic responsibilities. Embracing this pragmatic role offers the Communist Party a chance to survive. Its leaders therefore have good reason to initiate democratic change. Sure to challenge the Communist Party and stir debate, Democracy in China brings an original and important voice to an issue with far-reaching consequences for China and the world.
Author: Amy Rosenberg
Publisher: Springer
ISBN: 1493925431
Category : Medical
Languages : en
Pages : 384
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Book Description
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
Author: David DeBatto
Publisher: Grand Central Publishing
ISBN: 9780446559522
Category : Fiction
Languages : en
Pages : 432
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Book Description
In this second riveting novel, Army Counterintelligence Special Agent David DeLuca and his CI Team--an army within the Army--are up against a rogue enemy who has commandeered a deadly new technology. Original.
Author: Benjamin Gilad Ph D
Publisher: Independently Published
ISBN:
Category :
Languages : en
Pages : 236
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Book Description
In the age of too much data and too few breakthroughs, market "noise" is the biggest challenge for executives and managers. Finding growth opportunities requires a powerful filter. This filter is competitive intelligence- market insight that cuts through the din and propels companies to leap forward ahead of all others. It has little to do with more information on competitors. It has everything to do with making every market-facing manager more competitively skilled. In his characteristic blunt and entertaining style, the international expert and CEO of the Academy of Competitive Intelligence provides tools, tips, eye-opening case studies, and a new model to break through "data-driven" hype and change how management looks at competitive intelligence.
Author: United States. Bituminous Coal Division
Publisher:
ISBN:
Category : Administrative agencies
Languages : en
Pages : 1374
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Book Description
Author: Edward Douglas Fawcett
Publisher:
ISBN:
Category : First philosophy
Languages : en
Pages : 676
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Book Description
Author: Paul M. Duvall
Publisher: Pearson Education
ISBN: 0321630149
Category : Computers
Languages : en
Pages : 322
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Book Description
For any software developer who has spent days in “integration hell,” cobbling together myriad software components, Continuous Integration: Improving Software Quality and Reducing Risk illustrates how to transform integration from a necessary evil into an everyday part of the development process. The key, as the authors show, is to integrate regularly and often using continuous integration (CI) practices and techniques. The authors first examine the concept of CI and its practices from the ground up and then move on to explore other effective processes performed by CI systems, such as database integration, testing, inspection, deployment, and feedback. Through more than forty CI-related practices using application examples in different languages, readers learn that CI leads to more rapid software development, produces deployable software at every step in the development lifecycle, and reduces the time between defect introduction and detection, saving time and lowering costs. With successful implementation of CI, developers reduce risks and repetitive manual processes, and teams receive better project visibility. The book covers How to make integration a “non-event” on your software development projects How to reduce the amount of repetitive processes you perform when building your software Practices and techniques for using CI effectively with your teams Reducing the risks of late defect discovery, low-quality software, lack of visibility, and lack of deployable software Assessments of different CI servers and related tools on the market The book’s companion Web site, www.integratebutton.com, provides updates and code examples.
