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Author: Simona Maria Monti
Publisher: MDPI
ISBN: 3036510281
Category : Science
Languages : en
Pages : 196
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Book Description
It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.
Author: Simona Maria Monti
Publisher: MDPI
ISBN: 3036510281
Category : Science
Languages : en
Pages : 196
Get Book Here
Book Description
It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.
Author: Vladimir N. Uversky
Publisher: Springer
ISBN: 3319089218
Category : Science
Languages : en
Pages : 73
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Book Description
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Author: Emma Marris
Publisher: Bloomsbury Publishing USA
ISBN: 163557496X
Category : Nature
Languages : en
Pages : 353
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Book Description
Winner of the 2022 Rachel Carson Environment Book Award * Winner of the 2022 Science in Society Journalism Award (Books) * Finalist for the Los Angeles Times Book Prize “Thoughtful, insightful, and wise, Wild Souls is a landmark work.”--Ed Yong, author of An Immense World "Fascinating . . . hands-on philosophy, put to test in the real world . . . Marris believes that our idea of wildness--our obsession with purity--is misguided. No animal remains untouched by human hands . . . the science isn't the hard part. The real challenge is the ethics, the act of imagining our appropriate place in that world." --Outside Magazine From an acclaimed environmental writer, a groundbreaking and provocative new vision for our relationships with--and responsibilities toward--the planet's wild animals. Protecting wild animals and preserving the environment are two ideals so seemingly compatible as to be almost inseparable. But in fact, between animal welfare and conservation science there exists a space of underexamined and unresolved tension: wildness itself. When is it right to capture or feed wild animals for the good of their species? How do we balance the rights of introduced species with those already established within an ecosystem? Can hunting be ecological? Are any animals truly wild on a planet that humans have so thoroughly changed? No clear guidelines yet exist to help us resolve such questions. Transporting readers into the field with scientists tackling these profound challenges, Emma Marris tells the affecting and inspiring stories of animals around the globe--from Peruvian monkeys to Australian bilbies, rare Hawai'ian birds to majestic Oregon wolves. And she offers a companionable tour of the philosophical ideas that may steer our search for sustainability and justice in the non-human world. Revealing just how intertwined animal life and human life really are, Wild Souls will change the way we think about nature-and our place within it.
Author: Duncan Green
Publisher: Oxfam
ISBN: 0855985933
Category : Social Science
Languages : en
Pages : 540
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Book Description
Offers a look at the causes and effects of poverty and inequality, as well as the possible solutions. This title features research, human stories, statistics, and compelling arguments. It discusses about the world we live in and how we can make it a better place.
Author: Herbert Levine
Publisher: Academic Press
ISBN: 012817997X
Category : Medical
Languages : en
Pages : 773
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Book Description
Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. - Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity - Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies - Features a diverse range of chapter contributions from international leaders in the field
Author: Vladimir Uversky
Publisher: John Wiley & Sons
ISBN: 0470618310
Category : Science
Languages : en
Pages : 532
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Book Description
This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
Author: Food and Agriculture Organization of the United Nations
Publisher: Food & Agriculture Org.
ISBN: 925131411X
Category : Technology & Engineering
Languages : en
Pages : 325
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Book Description
This illustrated volume identifies the challenges and opportunities facing food and agriculture in the context of the 2030 Agenda, presents solutions for a more sustainable world and shows how FAO has been working in recent years to support its Member Nations in achieving the Sustainable Development Goals.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241547723
Category : Medical
Languages : en
Pages : 212
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Book Description
I. Defining "research"--II. Issues in study design . -- III. Harm and benefit -- IV. Voluntary informed consent -- V. Standard of care -- VI. Obligations to participants and communities -- VII. Privacy and confidentiality -- VIII. Professional ethics.
Author: Sandra Uwiringiyimana
Publisher: HarperCollins
ISBN: 0062470167
Category : Young Adult Nonfiction
Languages : en
Pages : 175
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Book Description
Junior Library Guild Selection * New York Public Library's Best Books for Teens * Goodreads Choice Awards Nonfiction Finalist * Chicago Public Library’s Best of the Best Books for Teens: Nonfiction * 2018 Texas Topaz Nonfiction List * YALSA's 2018 Quick Picks List * Bank Street's 2018 Best Books of the Year “This gut-wrenching, poetic memoir reminds us that no life story can be reduced to the word ‘refugee.’" —New York Times Book Review “A critical piece of literature, contributing to the larger refugee narrative in a way that is complex and nuanced.” —School Library Journal (starred review) This profoundly moving memoir is the remarkable and inspiring true story of Sandra Uwiringiyimana, a girl from the Democratic Republic of the Congo who tells the tale of how she survived a massacre, immigrated to America, and overcame her trauma through art and activism. Sandra was just ten years old when she found herself with a gun pointed at her head. She had watched as rebels gunned down her mother and six-year-old sister in a refugee camp. Remarkably, the rebel didn’t pull the trigger, and Sandra escaped. Thus began a new life for her and her surviving family members. With no home and no money, they struggled to stay alive. Eventually, through a United Nations refugee program, they moved to America, only to face yet another ethnic disconnect. Sandra may have crossed an ocean, but there was now a much wider divide she had to overcome. And it started with middle school in New York. In this memoir, Sandra tells the story of her survival, of finding her place in a new country, of her hope for the future, and how she found a way to give voice to her people.
Author: Deepa Narayan-Parker
Publisher: World Bank Publications
ISBN: 9780195216028
Category : Social Science
Languages : en
Pages : 342
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Book Description
A multi-country research initiative to understand poverty from the eyes of the poor, the Voices of the Poor project was undertaken to inform the World Bank's activities and the upcoming World Development Report 2000/01. The research findings are being published in three books: "Can Anyone Hear Us?" gathers the voices of over 40,000 poor women and men in 50 countries from the World Bank's participatory poverty assessments (Deepa Narayan, Raj Patel, Kai Schafft, Anne Rademacher, and Sarah Koch-Schulte, authors). "Crying Out for Change" pulls together new field work conducted in 1999 in 23 countries (Deepa Narayan, Robert Chambers, Meera Shah, and Patti Petesch, authors). "From Many Lands" offers regional patterns and country case-studies (Deepa Narayan and Patti Petesch, editors). Voices of the Poor marks the first time such an exercise has been undertaken in so many developing countries and transition economies around the world. It provides a unique and detailed picture of the life of the poor and explains the constraints poor people face to escape from poverty in a way that more traditional survey techniques do not capture well. Each of the three volumes demonstrates the importance of voice and power in poor people's definition of poverty. Voices of the Poor concludes that we need to expand our conventional views of poverty which focus on income expenditure, education, and health to include measures of voice and empowerment.
