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Author: Simona Maria Monti
Publisher: MDPI
ISBN: 3036510281
Category : Science
Languages : en
Pages : 196
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Book Description
It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.
Author: Simona Maria Monti
Publisher: MDPI
ISBN: 3036510281
Category : Science
Languages : en
Pages : 196
Get Book Here
Book Description
It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.
Author: Simona Maria Monti
Publisher:
ISBN: 9783036510293
Category :
Languages : en
Pages : 196
Get Book Here
Book Description
It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.
Author: Simona Maria Monti
Publisher: Mdpi AG
ISBN: 9783036531076
Category :
Languages : en
Pages : 130
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Book Description
This Special Issue includes seven full articles from more than 35 scientists from all around the world working in the amazing field of IDPs. The collected papers unveil novel aspects related to the wide world of IDPs. Using a variety of methods including biochemical, spectroscopic and computational techniques, they represent a step forward in the study and characterization of many IDPs involved in human diseases, with a focus on conformational features, environmental effects, recognition mechanisms and targeting.
Author: Prakash Kulkarni
Publisher:
ISBN: 9783036512631
Category :
Languages : en
Pages : 224
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Book Description
This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidating the mechanisms by which IDPs cause various human diseases, such as cancer, cardiovascular disease, amyloidosis, neurodegenerative diseases, diabetes, and genetic diseases, to name a few. Contributed by leading investigators in the field, this compendium serves as a valuable resource for researchers, clinicians as well as postdoctoral fellows and graduate students.
Author:
Publisher:
ISBN:
Category :
Languages : da
Pages : 621
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Book Description
Author: Mary L. Mulvihill
Publisher: Prentice Hall
ISBN: 9780838539286
Category : Diseases
Languages : en
Pages : 0
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Book Description
Author: Mark Zelman Ph.D.
Publisher: Pearson Higher Ed
ISBN: 0133424774
Category : Medical
Languages : en
Pages : 505
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Book Description
Today's most accessible, accurate, current, and engaging introduction to basic pathophysiology Human Diseases: A Systemic Approach, Eighth Edition is today's most comprehensive visual survey of the common diseases affecting each body system. This edition has been extensively updated and reorganized to present the field's latest knowledge more efficiently and intuitively than ever. Organized by organ system, it contains completely rewritten chapters on cancer, the nervous system, mental illness and cognitive disorders, the urinary system, the respiratory system, heredity, the endocrine system, cardiovascular system, and blood; as well as an entirely new chapter on the eye and ear (special senses). Its superior pedagogy has been enhanced with stronger foundational coverage of disease mechanisms, new Healthy Aging and Promote Your Health features, and extensive new artwork.
Author: United States. Congress. House. Committee on Foreign Affairs. Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations
Publisher:
ISBN:
Category : Genocide
Languages : en
Pages : 124
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Book Description
Author: Herbert Levine
Publisher: Academic Press
ISBN: 012817997X
Category : Medical
Languages : en
Pages : 773
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Book Description
Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field
Author: Vladimir N. Uversky
Publisher: Springer
ISBN: 3319089218
Category : Science
Languages : en
Pages : 73
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Book Description
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
