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Author: Clive R. Wood
Publisher: World Scientific
ISBN: 1848166281
Category : Medical
Languages : en
Pages : 490
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Book Description
Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.
Author: Clive R. Wood
Publisher: World Scientific
ISBN: 1848166281
Category : Medical
Languages : en
Pages : 490
Get Book Here
Book Description
Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.
Author: Marc Damelin
Publisher: Springer
ISBN: 3319781545
Category : Medical
Languages : en
Pages : 358
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Book Description
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Author: Jeffrey Wang
Publisher: Springer
ISBN: 3319130811
Category : Medical
Languages : en
Pages : 248
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Book Description
This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.
Author: Patrick J. Quinn
Publisher: Springer Science & Business Media
ISBN: 1402062583
Category : Technology & Engineering
Languages : en
Pages : 261
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Book Description
This book proposes alternative switched capacitor techniques which allow the achievement of higher intrinsic analogue functional accuracy than previously possible in such application areas as analogue filter and ADC design. The validity of the concepts developed and analyzed in Switched-Capacitor Techniques for High-Accuracy Filter and ADC Design has been demonstrated in practice with the design of CMOS SC bandpass filters and algorithmic ADC stages.
Author: Kenneth J. Olivier, Jr.
Publisher: John Wiley & Sons
ISBN: 1119060842
Category : Medical
Languages : en
Pages : 567
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Book Description
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Author: G. Perdikaris
Publisher: Springer Science & Business Media
ISBN: 9780792314226
Category : Technology & Engineering
Languages : en
Pages : 496
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Book Description
The primary objective of the book is to provide advanced undergraduate or frrst-year graduate engineering students with a self-contained presentation of the principles fundamental to the analysis, design and implementation of computer controlled systems. The material is also suitable for self-study by practicing engineers and is intended to follow a first course in either linear systems analysis or control systerns. A secondary objective of the book is to provide engineering and/or computer science audiences with the material for a junior/senior-level course in modern systems analysis. Chapters 2, 3, 4, and 5 have been designed with this purposein rnind. The emphasis in such a course is to develop the rnathernatical tools and methods suitable for the analysis and design of real-time systems such as digital filters. Thus, engineers and/or computer scientists who know how to program computers can understand the mathematics relevant to the issue of what it is they are programrning. This is especially important for those who may work in engineering and scientific environments where, for instance, programrning difference equations for real-time applications is becorning increasingly common. A background in linear algebra should be an adequate prerequisite for the systems analysis course. Chapter 1 of the book presents a brief introduction to computer controlled systems. It describes the general issues and terminology relevant to the analysis, design, and implementation of such systems.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 446
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Book Description
Author: Imran Ahmed
Publisher: Springer Science & Business Media
ISBN: 9048186528
Category : Technology & Engineering
Languages : en
Pages : 225
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Book Description
Pipelined ADCs have seen phenomenal improvements in performance over the last few years. As such, when designing a pipelined ADC a clear understanding of the design tradeoffs, and state of the art techniques is required to implement today's high performance low power ADCs.
Author:
Publisher:
ISBN:
Category : Caricatures and cartoons
Languages : en
Pages : 202
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Book Description
Author: Jennie R. Lill
Publisher: John Wiley & Sons
ISBN: 1119053102
Category : Science
Languages : en
Pages : 378
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Book Description
The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.
