Testing Drugs for Physical Dependence Potential and Abuse Liability PDF Download
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Author: Committee on Problems of Drug Dependence (U.S.)
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 172
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Book Description
Author: Committee on Problems of Drug Dependence (U.S.)
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 172
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Book Description
Author: Marian W. Fischman
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 420
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Book Description
Representatives from industry, academia and government discuss issues related to testing for drug abuse liability and dependence potential. Contributors critically assess current methods for evaluating drugs in human subjects and describe both the advantages and limitations of each approach. This information permits identification of areas in which further research and development are needed.
Author:
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 153
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Book Description
Author: Joseph V. Brady
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 154
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Book Description
Author: Carrie Markgraf
Publisher: Academic Press
ISBN: 0124202160
Category : Medical
Languages : en
Pages : 321
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Book Description
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy
Author:
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 432
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Book Description
Author: Michael A. Bozarth
Publisher: Springer Science & Business Media
ISBN: 1461248124
Category : Medical
Languages : en
Pages : 658
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Book Description
Methods of Assessing the Reinforcing Properties of Abused Drugs presents a synopsis of the preclinical procedures used to assess drug reinforcement. Researchers using one technique are provided with an overview of the other available methods, and clinicians who wish to evaluate drug abuse research reports can gain the necessary background from this volume. Although emphasis is placed on the methodological aspects of assessing drug reinforcement, some of the scientific conclusions derived from using these techniques are also presented. This edited collection offers a lasting framework for interpreting the results of current experimental findings.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309055334
Category : Medical
Languages : en
Pages : 330
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Book Description
Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Author:
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 132
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Book Description
Author: Committee on Federal Regulation of Methadone Treatment
Publisher: National Academies Press
ISBN: 0309598621
Category : Medical
Languages : en
Pages : 251
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Book Description
For nearly three decades, methadone hydrochloride has been the primary means of treating opiate addiction. Today, about 115,000 people receive such treatment, and thousands more have benefited from it in the past. Even though methadone's effectiveness has been well established, its use remains controversial, a fact reflected by the extensive regulation of its manufacturing, labeling, distribution, and use. The Food and Drug Administration regulates the safety and effectiveness of methadone, as it does for all drugs, and the Drug Enforcement Administration regulates it as a controlled substance. However, methadone is also subjected to a unique additional tier of regulation that prescribes how and under what circumstances it may be used to treat opiate addiction. Federal Regulation of Methadone Treatment examines current Department of Health and Human Services standards for narcotic addiction treatment and the regulation of methadone treatment programs pursuant to those standards. The book includes an evaluation of the effect of federal regulations on the provision of methadone treatment services and an exploration of options for modifying the regulations to allow optimal clinical practice. The volume also includes an assessment of alternatives to the existing regulations.
