Temporal Features in Resting State fMRI Data

Temporal Features in Resting State fMRI Data PDF Author: Xiaoping Philip Hu
Publisher: Frontiers Media SA
ISBN: 2889664082
Category : Science
Languages : en
Pages : 136

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Book Description

Temporal Features in Resting State fMRI Data

Temporal Features in Resting State fMRI Data PDF Author: Xiaoping Philip Hu
Publisher: Frontiers Media SA
ISBN: 2889664082
Category : Science
Languages : en
Pages : 136

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Book Description


An Introduction to Variational Autoencoders

An Introduction to Variational Autoencoders PDF Author: Diederik P. Kingma
Publisher:
ISBN: 9781680836226
Category : Computers
Languages : en
Pages : 102

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Book Description
An Introduction to Variational Autoencoders provides a quick summary for the of a topic that has become an important tool in modern-day deep learning techniques.

Spatio-temporal Dynamics of Human FMRI Resting Rate

Spatio-temporal Dynamics of Human FMRI Resting Rate PDF Author: Katharina Glomb
Publisher:
ISBN:
Category :
Languages : en
Pages : 107

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Book Description
Spontaneous brain activity, measured under the absence of any overt task, has been investigated under the label of "resting state" for about 20 years with rising interest. While it was known since the beginnings of modern electrophysiology that the brain exhibits spontaneous fluctuations also during rest, the discovery, in 1995, that these fluctuations possess a robust spatio-temporal structure had a profound impact on how we understand and investigate brain activity. In this dissertation, we characterize the spatio-temporal dynamics of resting state on a macroscopic level using fMRI recordings from humans and combining novel data analysis tools with theoretical models on the level of the whole brain. We demonstrate the presence of common patterns of functional connectivity, known as resting state networks (RSNs), that evolve in time in both empirical and model data. We show that spontaneous fluctuations and their statistics are determined by the structure of the brain network and its dynamics.

Selected Papers on Language and the Brain

Selected Papers on Language and the Brain PDF Author: N. Geschwind
Publisher: Springer Science & Business Media
ISBN: 9401020930
Category : Science
Languages : en
Pages : 567

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Book Description
Philosophers of science work not only with the methods of the sciences but with their contents as well. Substantive issues concerning the relation between mind and matter, between the material basis and the functions of cognition, have been central within the entire history of philosophy. We recall such philosophers as Aristotle, Descartes, the early Kant, Ernst Mach, and the early William James as directly inquiring of the organs and structures of thinking. Science and its philosophical self-criticism are especially and deeply united in the effort to understand the biological brain and human behavior, and so it requires no apology to include this collection of clinical studies among Boston Studies in the Philosophy of Science. The work of Dr. Norman Geschwind, well represented in this selection, explores the relation between structure and function, between the anatomy of the brain and the 'higher' behavior of men and women. As a clinical neurologist, Geschwind was led to these studies particularly by his in terest in those pathologies which have to do with human perception and language. His research into the anatomical substrates of specific dis orders-and strikingly the aphasias -present a fascinating and provocative examination of fundamental questions which will concern not neurologists alone but also psychologists, physicians, linguists, speech pathologists, educators, anthropologists, historians of medicine, and philosophers, among others, namely all those interested in the characteristic modes of human activity, in speech, in perception, and in the learning process generally.

Magnetoencephalography

Magnetoencephalography PDF Author: Selma Supek
Publisher: Springer
ISBN: 3642330452
Category : Technology & Engineering
Languages : en
Pages : 999

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Book Description
Magnetoencephalography (MEG) is an invaluable functional brain imaging technique that provides direct, real-time monitoring of neuronal activity necessary for gaining insight into dynamic cortical networks. Our intentions with this book are to cover the richness and transdisciplinary nature of the MEG field, make it more accessible to newcomers and experienced researchers and to stimulate growth in the MEG area. The book presents a comprehensive overview of MEG basics and the latest developments in methodological, empirical and clinical research, directed toward master and doctoral students, as well as researchers. There are three levels of contributions: 1) tutorials on instrumentation, measurements, modeling, and experimental design; 2) topical reviews providing extensive coverage of relevant research topics; and 3) short contributions on open, challenging issues, future developments and novel applications. The topics range from neuromagnetic measurements, signal processing and source localization techniques to dynamic functional networks underlying perception and cognition in both health and disease. Topical reviews cover, among others: development on SQUID-based and novel sensors, multi-modal integration (low field MRI and MEG; EEG and fMRI), Bayesian approaches to multi-modal integration, direct neuronal imaging, novel noise reduction methods, source-space functional analysis, decoding of brain states, dynamic brain connectivity, sensory-motor integration, MEG studies on perception and cognition, thalamocortical oscillations, fetal and neonatal MEG, pediatric MEG studies, cognitive development, clinical applications of MEG in epilepsy, pre-surgical mapping, stroke, schizophrenia, stuttering, traumatic brain injury, post-traumatic stress disorder, depression, autism, aging and neurodegeneration, MEG applications in cognitive neuropharmacology and an overview of the major open-source analysis tools.

Origins of the Resting-State fMRI Signal

Origins of the Resting-State fMRI Signal PDF Author: Jean Chen
Publisher: Frontiers Media SA
ISBN: 2889662853
Category : Science
Languages : en
Pages : 188

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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Toward Improved Characterization of Brain Network Temporal Properties with Functional Magnetic Resonance Imaging

Toward Improved Characterization of Brain Network Temporal Properties with Functional Magnetic Resonance Imaging PDF Author: Catherine Elizabeth Chang
Publisher: Stanford University
ISBN:
Category :
Languages : en
Pages : 237

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Book Description
Functional magnetic resonance imaging (fMRI) based on blood-oxygen level dependent (BOLD) contrast is a powerful technique for non-invasive measurement of brain activity. Recent fMRI studies have revealed that the spontaneous BOLD fluctuations of the human brain organize into distributed, temporally-coherent networks ("resting-state networks"; RSNs). Examination of RSNs has yielded valuable insight into neural organization and development, and demonstrates potential as a biomarker for conditions such as Alzheimer's disease and depression. However, the accuracy by which the spatio-temporal properties of RSNs can be delineated using fMRI is compromised by the presence of physiological (cardiac and respiratory) noise and vascular hemodynamic variability. Further, our present understanding of how RSNs may interact and support cognitive function has been limited by the fact that the vast majority of studies to-date analyze RSNs in a manner that assumes temporal stationarity. Here, we describe efforts to correct for non-neural physiological influences on the BOLD signal, as well as investigations into the dynamic character of resting-state network connectivity. It is found that low-frequency variations in cardiac and respiratory processes account for significant noise across widespread gray matter regions, and that a constrained deconvolution approach may prove effective for modeling and reducing their effects. Application of the proposed noise-reduction procedure is observed to yield negative correlations between the spontaneous fluctuations of two major RSNs. The relationship between respiratory volume changes and the BOLD signal is further examined by simultaneously monitoring and comparing chest expansion data, end-tidal gas concentrations, and spontaneous BOLD fluctuations. The use of a breath-holding task is proposed for quantifying regional differences in BOLD signal timing that arise from local vasomotor response delays; such non-neural timing delays are found to impact inferences of resting-state connectivity and causality. Finally, a preliminary analysis of non-stationary connectivity between RSNs is performed using wavelet and sliding-window approaches, and it is observed that interactions between networks may reconfigure on time-scales of seconds to minutes.

Advances in Resting-State Functional MRI-

Advances in Resting-State Functional MRI- PDF Author: Jean Chen
Publisher: Elsevier
ISBN: 0323985459
Category : Psychology
Languages : en
Pages : 382

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Book Description
Advances in Resting-State Functional MRI: Methods, Interpretation, and Applications gives readers with basic neuroimaging experience an up-to-date and in-depth understanding of the methods, opportunities, and challenges in rs-fMRI. The book covers current knowledge gaps in rs-fMRI, including "what are biologically plausible brain networks," "how to tell what part is noise," "how to perform quality assurance on the data," "what are the spatial and temporal limits of our ability to resolve FC," and "how to best identify network features related to individual differences or disease state". This book is an ideal reference for neuroscientists, computational neuroscientists, psychologists, biomedical engineers, physicists and medical physicists. Both new and more advanced researchers alike will be able to discover new information distilled from the past decade of research to become well-versed in rs-fMRI-related topics. Presents the first book to explain the latest methods, opportunities and challenges of Resting-state Functional MRI Edited and authored by leading researchers in fMRI Includes neuroscientific and clinical applications

Population Based Spatio-temporal Probabilistic Modelling of FMRI Data

Population Based Spatio-temporal Probabilistic Modelling of FMRI Data PDF Author: Nahed Alowadi
Publisher:
ISBN:
Category : Magnetic resonance imaging
Languages : en
Pages : 0

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Book Description
High-dimensional functional magnetic resonance imaging (fMRI) data is characterized by complex spatial and temporal patterns related to neural activation. Mixture based Bayesian spatio-temporal modelling is able to extract spatiotemporal components representing distinct haemodyamic response and activation patterns. A recent development of such approach to fMRI data analysis is so-called spatially regularized mixture model of hidden process models (SMM-HPM). SMM-HPM can be used to reduce the four-dimensional fMRI data of a pre-determined region of interest (ROI) to a small number of spatio-temporal prototypes, sufficiently representing the spatio-temporal features of the underlying neural activation. Summary statistics derived from these features can be interpreted as quantification of (1) the spatial extent of sub-ROI activation patterns, (2) how fast the brain respond to external stimuli; and (3) the heterogeneity in single ROIs. This thesis aims to extend the single-subject SMM-HPM to a multi-subject SMM-HPM so that such features can be extracted at group-level, which would enable more robust conclusion to be drawn.

Neuroscience in the 21st Century

Neuroscience in the 21st Century PDF Author: Donald W. Pfaff
Publisher: Springer
ISBN: 9781493934737
Category : Medical
Languages : en
Pages : 0

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Book Description
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.