Author: James G. Smith
Publisher:
ISBN:
Category : Kaons
Languages : en
Pages : 500
Book Description
Tau 96
Author: James G. Smith
Publisher:
ISBN:
Category : Kaons
Languages : en
Pages : 500
Book Description
Publisher:
ISBN:
Category : Kaons
Languages : en
Pages : 500
Book Description
'96 Electroweak Interactions and Unified Theories
Author: J. Thanh Van Tran
Publisher: Atlantica Séguier Frontières
ISBN: 9782863322055
Category : Electroweak interactions
Languages : en
Pages : 536
Book Description
Publisher: Atlantica Séguier Frontières
ISBN: 9782863322055
Category : Electroweak interactions
Languages : en
Pages : 536
Book Description
Tau oligomers
Author: Jesus Avila
Publisher: Frontiers E-books
ISBN: 288919261X
Category : Medicine (General)
Languages : en
Pages : 114
Book Description
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Publisher: Frontiers E-books
ISBN: 288919261X
Category : Medicine (General)
Languages : en
Pages : 114
Book Description
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Tau Pathology in Neurological Disorders
Author: Sonia Do Carmo
Publisher: Frontiers Media SA
ISBN: 2889716252
Category : Science
Languages : en
Pages : 268
Book Description
Publisher: Frontiers Media SA
ISBN: 2889716252
Category : Science
Languages : en
Pages : 268
Book Description
Burma
Author: United States. Office of Geography
Publisher:
ISBN:
Category : Burma
Languages : en
Pages : 752
Book Description
Publisher:
ISBN:
Category : Burma
Languages : en
Pages : 752
Book Description
The GTO Observing Program
Author:
Publisher:
ISBN:
Category : Astronomy
Languages : en
Pages : 270
Book Description
Publisher:
ISBN:
Category : Astronomy
Languages : en
Pages : 270
Book Description
The Twelfth General Catalogue of the Psi Upsilon Fraternity
Author: Psi Upsilon Fraternity
Publisher:
ISBN:
Category : Greek letter societies
Languages : en
Pages : 960
Book Description
Publisher:
ISBN:
Category : Greek letter societies
Languages : en
Pages : 960
Book Description
Annual Circular of the Illinois Industrial University
Author: University of Illinois (Urbana-Champaign campus)
Publisher:
ISBN:
Category :
Languages : en
Pages : 592
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 592
Book Description
Catalogue of the Psi Upsilon Fraternity
Author: Psi Upsilon Fraternity
Publisher:
ISBN:
Category : Universities and colleges
Languages : en
Pages : 960
Book Description
Publisher:
ISBN:
Category : Universities and colleges
Languages : en
Pages : 960
Book Description
The ATO Palm
Author:
Publisher:
ISBN:
Category : Greek letter societies
Languages : en
Pages : 362
Book Description
Publisher:
ISBN:
Category : Greek letter societies
Languages : en
Pages : 362
Book Description