Author: Carmen Scholz
Publisher: OUP USA
ISBN: 9780841227989
Category : Science
Languages : en
Pages : 0
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Book Description
Provides detailed information on cutting-edge research in the field of polymer science for biomedical and pharmaceutical applications.
Author: Carmen Scholz
Publisher:
ISBN: 9780841227996
Category : Biomedical materials
Languages : en
Pages : 363
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Book Description
Author: Vandana Patravale
Publisher: Elsevier
ISBN: 0323954979
Category : Medical
Languages : en
Pages : 482
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Book Description
Polymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the required properties and performance for a range of advanced pharmaceutical and biomedical applications. The book begins by introducing polymers for pharmaceutical and biomedical applications, examining classification, basic properties, structures, and grades. This is followed by in-depth chapters focusing on synthesis and modification, characterization techniques, and dissolution and solubility of polymers for pharmaceutical applications. Key applications are then highlighted, with chapters explaining in detail the preparation of polymers for conventional dosage, modified drug delivery, conjugates, advanced drug and gene delivery, medical devices, pharmaceutical packaging, tissue engineering, artificial organs, and dentistry. Throughout the book, the aim is to provide accessible, step-by-step coverage, supported by diagrams and case studies. Finally, safety and regulatory aspects are discussed. This is a valuable resource for all those who are newly approaching the field of polymers and product development for pharmaceutical and biomedical applications. This includes researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, and scientists and R&D professionals in an industrial setting. Explains fundamental concepts relating to the synthesis, modification, and characterization of polymers Guides the reader towards successful selection of polymer systems for specific target applications Addresses key challenges in this field that are supported by case studies and regulatory information
Author: Hriday Bera
Publisher: Woodhead Publishing
ISBN: 0128214570
Category : Medical
Languages : en
Pages : 789
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Book Description
Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists. Provides a concise overview of tailor-made and functionalized biopolymer systems for biomedical applications Covers a range of modified biopolymers, biopolymeric composites and biopolymer-based systems in drug delivery, development of artificial organs, diagnostic applications, and more Describes characterization, synthesis and functionalization of biopolymers and biopolymers systems
Author: Karen K. Gleason
Publisher: John Wiley & Sons
ISBN: 3527690263
Category : Technology & Engineering
Languages : en
Pages : 488
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Book Description
The method of CVD (chemical vapor deposition) is a versatile technique to fabricate high-quality thin films and structured surfaces in the nanometer regime from the vapor phase. Already widely used for the deposition of inorganic materials in the semiconductor industry, CVD has become the method of choice in many applications to process polymers as well. This highly scalable technique allows for synthesizing high-purity, defect-free films and for systematically tuning their chemical, mechanical and physical properties. In addition, vapor phase processing is critical for the deposition of insoluble materials including fluoropolymers, electrically conductive polymers, and highly crosslinked organic networks. Furthermore, CVD enables the coating of substrates which would otherwise dissolve or swell upon exposure to solvents. The scope of the book encompasses CVD polymerization processes which directly translate the chemical mechanisms of traditional polymer synthesis and organic synthesis in homogeneous liquids into heterogeneous processes for the modification of solid surfaces. The book is structured into four parts, complemented by an introductory overview of the diverse process strategies for CVD of polymeric materials. The first part on the fundamentals of CVD polymers is followed by a detailed coverage of the materials chemistry of CVD polymers, including the main synthesis mechanisms and the resultant classes of materials. The third part focuses on the applications of these materials such as membrane modification and device fabrication. The final part discusses the potential for scale-up and commercialization of CVD polymers.
Author: Hung VanThanh Nguyen
Publisher:
ISBN:
Category :
Languages : en
Pages : 356
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Book Description
Chapter 1: Introduction to Bottlebrush Polymers as Carrier Platforms for Drug Delivery Biomedical Applications A brief intro to the current state of nanotechnology in drug delivery applications is provided, including the common myths and facts, design considerations, as well as important challenges towards successful translation to the clinic. In this context, the promises of bottlebrush polymers as a next-generation delivery platform, and the branched macromonomer approach is also discussed. Chapter 2: Scalable Synthesis of Multivalent Macromonomers for ROMP Here, we report the three-step convergent synthesis (two-step longest linear sequence) of a divalent exo-norbornene imide capable of efficient coupling with various nucleophiles and azides to produce diversely functionalized branched macromonomers optimized for ring-opening metathesis polymerization (ROMP). In addition, we describe an efficient iterative procedure for the synthesis of tri- and tetra-valent branched macromonomers. We demonstrate the use of these branched macromonomers for the synthesis of Janus bottlebrush block copolymers as well as for the generation of bottlebrush polymers with up to three conjugated small molecules per repeat unit. Chapter 3: Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors We report nitroxide-functionalized BASP organic radical contrast agents (ORCAs) that overcome the low contrast and poor in vivo stability associated with nitroxide-based MRI contrast agents. These features combine to provide for accumulation of a sufficient concentration of BASP-ORCA in murine subcutaneous tumors up to 20 h following systemic administration such that MRI contrast on par with metal-based agents is observed. Chapter 4: Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging We report a modular and scalable synthetic approach to nitroxide-based BASP-ORCAs with high nitroxide loadings, excellent stability in vivo, no acute toxicity, and highly desirable pharmacokinetic and biodistribution profiles for longitudinal detection of tumors by MRI. When injected intravenously into mice bearing subcutaneous plasmacytomas, BASP-ORCA3 affords distinct in vivo visualization of tumors on translationally relevant time scales while enabling efficient mapping of tumor necrosis, an important biomarker to predict therapeutic outcomes. Moreover, BASP-ORCA3 allows for detection of millimetric tumor implants in a disseminated murine model of advanced-stage human ovarian cancer that possess genetic, histological, and vascular characteristics that are similar to those seen in patients. Chapter 5: Brush-Arm Star Polymers as a Convergent Designer Platform for Theranostic Nanomaterials: Real Time Magnetic Resonance-Guided Drug Delivery Here, we report the conceptualization and execution of a novel theranostic platform system with heavy emphasis on the independence of its individual components: therapeutic payload, imaging moiety, stimuli trigger, and delivery platform. This would in turn allow for systematic variation of each player while minimizing disturbance towards the whole system. Specifically, we constructed a metal-free MRI-based brush-arm star polymer (BASP) bearing a doxorubicin (DOX) payload that is capable of generating changes in MRI contrast upon the release of the therapeutic payload. Moreover, via rational chemical design, we can specifically change not only the response trigger, but also the response rate under a specific stimulus. Chapter 6: Chiral Unimolecular-armed Bottlebrush as a Biological Probe Iterative exponential growth (IEG) is used to prepare a series of stereoisomeric norbomene-terminated macromonomers (MMs) with varying stereochemical sequence, length, and distance between sidechain groups. Ring-opening metathesis polymerization (ROMP) of these MMs along with a dye-labeled monomer provided stereoisomeric, fluorescent chiral unimolecular-arm bottlebrush polymers (CUBPs) that could be used as probes for understanding the role of chirality in biological systems, which were examined in both an in vitro and in vivo context. Intriguingly, via precise rational chemical modifications, these chirality-driven behaviors can be modulated, providing a proof-of-principle that the stereochemistry of BPs can be used to tailor their interactions with biological systems. Chapter 7: Polyoxazoline Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Nitroxide-Based Organic Radical Contrast Agents The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ROMP approach is described. Additionally, PEtOx-based BASPs with nitroxide radicals localized at the core-shell interface were also prepared, which displayed relaxivity values on par with state-of-the-art polyethylene glycol (PEG)-based nitroxide materials.
Author: Narendra Pal Singh Chauhan
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110638630
Category : Science
Languages : en
Pages : 458
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Book Description
Biocidal polymers are designed to inhibit or kill microorganisms such as bacteria, fungi and protozoans. This book summarizes recent findings in the synthesis, modification and characterization of various antimicrobial polymers ranging from plastics and elastomers to biomimetic and biodegradable polymers. Modifications with different antimicrobial agents as well as antimicrobial testing methods are described in a comprehensive manner.
Author: Abraham J Domb
Publisher: Royal Society of Chemistry
ISBN: 1788018540
Category : Technology & Engineering
Languages : en
Pages : 546
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Book Description
With the need to combat emerging infectious diseases, research around antimicrobial biomaterials and their applications is booming. This book provides the field with a much-needed fundamental overview of the science, addressing the chemistry of a broad range of biomaterial types, and their applications in the biomedical industry. Materials covered include polymers, from those with inherent antimicrobial activity to those that release antimicrobial agents, antimicrobial ceramics and inorganic compounds, such as metal based antimicrobial additives, and the developing field of biomimetic materials, are discussed. Surfaces, coatings and adhesives are covered, whilst the applications of these antimicrobial materials in biomedical applications, from catheters to orthopaedics, dentistry to ophthalmology, are explored. Edited by international leaders and with contributions from the best in the field, this book is the go-to resource for graduates and researchers in biomaterials science, biomedical engineering, chemical engineering, and materials and polymer chemistry.
Author: Emo Chiellini
Publisher: Springer Science & Business Media
ISBN: 1461576431
Category : Technology & Engineering
Languages : en
Pages : 411
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Book Description
This book contains the collected papers presented at the Inter national Symposium on Polymers in Medicine, Biomedical and Pharma cological Applications, which was held at Porto Cervo, Italy, May 24-28, 1982. To the best of our knowledge, this symposium was the first to be organized in Italy entirely devoted to the several aspects of the use of synthetic and semisynthetic macromolecular materials in the field of biomedical and pharmacological applications. The inten~ tion of the Organizing Committee of the symposium was the promotion of a scientific and cultural initiative to gain the attention of various experts in line research of the potential of suitably de signed "man-made" polymeric materials in biomedical applications. With highly qualified and worldwide attendance, the above goal was fully satisfied. Indeed the opportunity of meeting to gether in a well conceived and discreet corner of the world, scien tists with different cultural backgrounds and objectives helped ex tend the meaning of the symposium far beyond the Italian borders and the perspectives of the National Research Council of Italy (CNR) , the major sponsor of the meeting.
Author: M. N. V. Ravi Kumar
Publisher: CRC Press
ISBN: 1315341166
Category : Medical
Languages : en
Pages : 401
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Book Description
In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.
