Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems PDF Download
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Author: Velichka Andonova
Publisher:
ISBN:
Category : Science
Languages : en
Pages :
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Book Description
One of the most promising strategies to improve the bioavailability of active pharmaceutical ingredients is based on the association of the drug with colloidal carriers, for example, polymeric nanoparticles, which are stable in biological environment, protective for encapsulated substances and able to modulate physicochemical characteristics, drug release and biological behaviour. The synthetic polymers possess unique properties due to their chemical structure. Some of them are characterized with mucoadhesiveness; another can facilitate the penetration through mucous layers; or to be stimuli responsive, providing controlled drug release at the target organ, tissues or cells; and all of them are biocompatible and versatile. These are suitable vehicles of nucleic acids, oligonucleotides, DNA, peptides and proteins. This chapter aims to look at the 'hot spots' in the design of synthetic polymer nanoparticles as an intelligent drug delivery system in terms of biopharmaceutical challenges and in relation to the route of their administration: the non-invasive-oral, transdermal, transmucosal (nasal, buccal/sublingual, vaginal, rectal and ocular) and inhalation routes-and the invasive parenteral route.
Author: Velichka Andonova
Publisher:
ISBN:
Category : Science
Languages : en
Pages :
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Book Description
One of the most promising strategies to improve the bioavailability of active pharmaceutical ingredients is based on the association of the drug with colloidal carriers, for example, polymeric nanoparticles, which are stable in biological environment, protective for encapsulated substances and able to modulate physicochemical characteristics, drug release and biological behaviour. The synthetic polymers possess unique properties due to their chemical structure. Some of them are characterized with mucoadhesiveness; another can facilitate the penetration through mucous layers; or to be stimuli responsive, providing controlled drug release at the target organ, tissues or cells; and all of them are biocompatible and versatile. These are suitable vehicles of nucleic acids, oligonucleotides, DNA, peptides and proteins. This chapter aims to look at the 'hot spots' in the design of synthetic polymer nanoparticles as an intelligent drug delivery system in terms of biopharmaceutical challenges and in relation to the route of their administration: the non-invasive-oral, transdermal, transmucosal (nasal, buccal/sublingual, vaginal, rectal and ocular) and inhalation routes-and the invasive parenteral route.
Author: Suresh P Vyas
Publisher: Academic Press
ISBN: 0323913997
Category : Business & Economics
Languages : en
Pages : 626
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Book Description
Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications
Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128136642
Category : Science
Languages : en
Pages : 770
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Book Description
Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery Assesses how molecular organic frameworks lead to more effective drug delivery systems
Author: Prashant Kesharwani
Publisher: Academic Press
ISBN: 0128173319
Category : Medical
Languages : en
Pages : 434
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Book Description
Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles
Author: Glen S. Kwon
Publisher: CRC Press
ISBN: 9780824725327
Category : Medical
Languages : en
Pages : 680
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Book Description
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Author: Ali Demir Sezer
Publisher: BoD – Books on Demand
ISBN: 9535122479
Category : Medical
Languages : en
Pages : 400
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Book Description
This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Author: Saurabh Bhatia
Publisher: Springer
ISBN: 3319411292
Category : Technology & Engineering
Languages : en
Pages : 235
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Book Description
This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications. The applications of various bio-medical and other future potential uses are covered and examined in depth. Systematic discussion of current leading natural polymers is also included.
Author: José A. Pomposo
Publisher: John Wiley & Sons
ISBN: 3527806393
Category : Technology & Engineering
Languages : en
Pages : 504
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Book Description
This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Author: Christine Vauthier
Publisher: Springer
ISBN: 3319414216
Category : Medical
Languages : en
Pages : 649
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Book Description
This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.
Author: Boreddy Reddy
Publisher: BoD – Books on Demand
ISBN: 9535135937
Category : Science
Languages : en
Pages : 210
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Book Description
This book on Acrylic Polymers for Healthcare presents eight chapters organised into three parts by providing new ideas in design, synthesis and a detailed study of new acrylate materials in healthcare applications. Part I represents Chapters 1, 2, 3 and 4 focussing on toning up of technologies for making dental dentures with better properties. Part II comprises Chapters 5 and 6 dealing with synthetic polymer-based nanoparticles as intelligent drug delivery systems and bismuth nanoparticles for improved green light emission. Part III represents Chapters 7 and 8 describing the aspects of mitigation of acrylamide in foods in the context of an African perspective and the importance of acrylic-based polymeric adsorbents so that the reader can get an idea about the various types and forms of polymeric materials used for the removal of heavy metals from water.
