Synthetic and Modelling Studies on Macrolide Antibiotics PDF Download
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Author: Ian Stansfield
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Ian Stansfield
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: I. J. Burnside
Publisher:
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Category :
Languages : en
Pages :
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Author: Shan Wang
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 378
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Author: Satoshi Omura
Publisher: Academic Press
ISBN: 9780125264518
Category : Medical
Languages : en
Pages : 668
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Book Description
Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.
Author: W. Schönfeld
Publisher: Birkhäuser
ISBN: 3034881053
Category : Medical
Languages : en
Pages : 327
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Book Description
There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to clinical use. Starting from a historic overview, the essential basic parameters - efficacy, pharmacokinetics, pharmacodynamics, and pharmacology - are highlighted in order to introduce the reader to the rationale for clinical use of macrolides. The following group of chapters cover the complex chemistry of the macro lactone structures, giving historic background, basic structure-activity relation ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.
Author: Jun Lin
Publisher: Frontiers Media SA
ISBN: 2889195260
Category : Antibiotics
Languages : en
Pages : 226
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Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781719520
Category : Medical
Languages : en
Pages : 848
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Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Author: Vilas Nathuram Kale
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 0
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The major portion of this thesis deals with the use of carbohydrates as "chiral templates" for the synthesis of thiathromboxane A^, the chiral segments of the macrolide antibiotics and related compounds. In the first chapter, the synthesis of a model compound 31 having the representative 2-oxa-6-thiabicyclo13.1.1]heptane system present in the thiathromboxane A^ (a thromboxane A^ analogue) is described. The detailed NMR analysis of 31 is carried out to determine the favored conformation of this rigid system. The latter part of this chapter deals with the formal total synthesis of 9a,lla-thiathromboxane A" methyl ester 7 starting from z ~ levoglucosan (1,6-anhydro-B-D-glucopyranose). Levoglucosan is converted into the 9-epi-thromboxane B2 derivative 48 which has been converted into 7 by Hamanaka and coworkers. The configurations of 48 and '•v J its diastereomer 49 at the C (15) are discussed. In the second chapter, an operationally simple process to introduce stereoselectively a methyl group at the C(6)-position of the pyranosyl enone 56 involving 'conformational diastereoface-differentiation' in the conjugate additions of CH^Cu.BF^ and methyllithium-HMPA is described. The preferred conformations of the conjugate adducts 57 and 53 are investigated by nuclear Overhauser enhancement experiments. In the last part of this chapter, the preparation of a chiral synthon suitable for the synthesis of the CQ11-CC151 and C Ql* ItC C15v' ) segments of the macrolide antibiotic elaiophylin Cazalomycin-Bl is discussed. An efficient method for the regio- and stereocontrolled epoxide ring opening of the conformationally rigid epoxy-tosylate 33 with trialkylalanes is described. In the final chapter, a method for generation of carbon-carbon double bonds from ^-oxygenated phenylseleno, phenylthio, and iodo species is described. It is shown that chlorotrimethylsilane and sodium iodide in acetonitrile is a useful reagent for such a transformation. The reaction is efficient and has a predictable stereochemical outcome.
Author:
Publisher: Academic Press
ISBN: 0128173173
Category : Medical
Languages : en
Pages : 290
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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 776
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