Author: Patricia Dawn MacLeod
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Synthesis of Chiral Tetrahydroisoquinolines and Their Applications in Asymmetric Catalysis
Author: Patricia Dawn MacLeod
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Handbook of Asymmetric Heterogeneous Catalysis
Author: Kuiling Ding
Publisher: John Wiley & Sons
ISBN: 3527623027
Category : Science
Languages : en
Pages : 466
Book Description
In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in both academia and industry as well as those working in the fine chemical and pharmaceutical industry.
Publisher: John Wiley & Sons
ISBN: 3527623027
Category : Science
Languages : en
Pages : 466
Book Description
In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in both academia and industry as well as those working in the fine chemical and pharmaceutical industry.
Chiral Ferrocenes in Asymmetric Catalysis
Author: Li-Xin Dai
Publisher: John Wiley & Sons
ISBN: 3527322809
Category : Science
Languages : en
Pages : 433
Book Description
This book meets the long-felt need for a reference on ferrocenes with the focus on catalysis. It provides a thorough overview of the synthesis and characterization of different types of chiral ferrocene ligands, their application to various catalytic asymmetric reactions, and versatile chiral materials as well as drug intermediates synthesized from them. Written by the "who's who" of ferrocene catalysis, this is a guide to the design of new ferrocene ligands and synthesis of chiral synthetic intermediates, and will thus be useful for organic, catalytic and synthetic chemists working in academia, industrial research or process development.
Publisher: John Wiley & Sons
ISBN: 3527322809
Category : Science
Languages : en
Pages : 433
Book Description
This book meets the long-felt need for a reference on ferrocenes with the focus on catalysis. It provides a thorough overview of the synthesis and characterization of different types of chiral ferrocene ligands, their application to various catalytic asymmetric reactions, and versatile chiral materials as well as drug intermediates synthesized from them. Written by the "who's who" of ferrocene catalysis, this is a guide to the design of new ferrocene ligands and synthesis of chiral synthetic intermediates, and will thus be useful for organic, catalytic and synthetic chemists working in academia, industrial research or process development.
Catalytic Asymmetric Synthesis
Author: Iwao Ojima
Publisher: Wiley-VCH
ISBN:
Category : Science
Languages : en
Pages : 888
Book Description
Since this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields-from medicine to materials science. Catalytic Asymmetric Synthesis, Second Edition addresses these rapid changes through new or substantially revised contributions from highly recognized world leaders in the field.
Publisher: Wiley-VCH
ISBN:
Category : Science
Languages : en
Pages : 888
Book Description
Since this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields-from medicine to materials science. Catalytic Asymmetric Synthesis, Second Edition addresses these rapid changes through new or substantially revised contributions from highly recognized world leaders in the field.
Synthesis of Chiral Catalysts and Their Application to Asymmetric Cross-coupling Reactions and Selective Hydrogenation
Author: Hussein Mohamed Galal El-Din Ali
Publisher:
ISBN:
Category : Hydrogenation
Languages : en
Pages : 392
Book Description
Publisher:
ISBN:
Category : Hydrogenation
Languages : en
Pages : 392
Book Description
Chiral Reactions in Heterogeneous Catalysis
Author: V. Dubois
Publisher: Springer Science & Business Media
ISBN: 1461519098
Category : Science
Languages : en
Pages : 304
Book Description
It was a great honor for us to organize ChiCat, a symposium devoted to Chiral Reactions in Heterogeneous Catalysis and to be the hostsofmore than 120 scientists coming from everywhere in the industrialized world, to celebrate together one century of existence ofInstitut Meurice. This school was established in 1892when an industrial chemist, named Albert Meurice, decided to educate practical chemists according to the perceived needs ofthe industry ofthat time. This is exactly what we are still trying to do. It is the reason why, thirty years ago, we started a research activity in catalysis, and why we progressively devote this research to the applications of catalysis in the field of fine chemicals. In this respect, we are very close to another initiative of Albert Meurice, who started the first production of synthetic pharmaceuticals in Belgium during World War I. This business later on became a part ofthe Belgian corporation DCB, still very active in pharmaceuticals today. The school created by Albert Meurice merged in the fifties with another school that had been created to meet the same needs in the field of the food industries, mainly distilleries and breweries. This merger was done in the frame of the establishment of CERIA. For people in catalysis, ceria stands for cerium oxide, but for those who engineered the concept, CERIA stood for Center of Education and Research for the Food and Chemical Industries.
Publisher: Springer Science & Business Media
ISBN: 1461519098
Category : Science
Languages : en
Pages : 304
Book Description
It was a great honor for us to organize ChiCat, a symposium devoted to Chiral Reactions in Heterogeneous Catalysis and to be the hostsofmore than 120 scientists coming from everywhere in the industrialized world, to celebrate together one century of existence ofInstitut Meurice. This school was established in 1892when an industrial chemist, named Albert Meurice, decided to educate practical chemists according to the perceived needs ofthe industry ofthat time. This is exactly what we are still trying to do. It is the reason why, thirty years ago, we started a research activity in catalysis, and why we progressively devote this research to the applications of catalysis in the field of fine chemicals. In this respect, we are very close to another initiative of Albert Meurice, who started the first production of synthetic pharmaceuticals in Belgium during World War I. This business later on became a part ofthe Belgian corporation DCB, still very active in pharmaceuticals today. The school created by Albert Meurice merged in the fifties with another school that had been created to meet the same needs in the field of the food industries, mainly distilleries and breweries. This merger was done in the frame of the establishment of CERIA. For people in catalysis, ceria stands for cerium oxide, but for those who engineered the concept, CERIA stood for Center of Education and Research for the Food and Chemical Industries.
Privileged Chiral Ligands and Catalysts
Author: Qi-Lin Zhou
Publisher: Wiley-VCH
ISBN: 9783527327041
Category : Technology & Engineering
Languages : en
Pages : 484
Book Description
Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives
Publisher: Wiley-VCH
ISBN: 9783527327041
Category : Technology & Engineering
Languages : en
Pages : 484
Book Description
Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives
Application of Asymmetric Catalysis for the Synthesis and Medicinal Chemistry Study of Polyketide Natural Products
Author: Yanping Wang
Publisher:
ISBN:
Category : Cell-mediated cytotoxicity
Languages : en
Pages : 190
Book Description
Most polyketide natural products are chiral and exist in enantiomerically pure form, often containing more than one stereogenic centers. During synthesis of the polyketide natural products, these centers can be either derived from nature's chiral pools or from resolution of racemic mixtures. Alternatively, the chiral center can be installed using asymmetric catalysis. The asymmetric catalysis approach has the potential to be the most efficient strategy for the construction of libraries of stereochemical polyketide natural products by the installation stereochemistry into the achiral starting materials. Asymmetric catalysis was used to synthesize two categories of polyketide natural products, cryptocaryols and tetrahydrolipstatin, in 25 and 10 longest linear steps, respectively. In addition, five cryptocaryol and eight tetrahydrolipstatin stereochemical analogues were also accessed, which demonstrated the versatility of the catalytic asymmetric approach. The asymmetric catalysis strategy is also applied to an ongoing project the total synthesis of EBC-23. These stereochemical analogues were used to develop structure activity relationship profiles for cryptocaryols and tetrahydrolipstatin cytotoxicity against cancer cell lines (e.g. MCF-7 and H460).
Publisher:
ISBN:
Category : Cell-mediated cytotoxicity
Languages : en
Pages : 190
Book Description
Most polyketide natural products are chiral and exist in enantiomerically pure form, often containing more than one stereogenic centers. During synthesis of the polyketide natural products, these centers can be either derived from nature's chiral pools or from resolution of racemic mixtures. Alternatively, the chiral center can be installed using asymmetric catalysis. The asymmetric catalysis approach has the potential to be the most efficient strategy for the construction of libraries of stereochemical polyketide natural products by the installation stereochemistry into the achiral starting materials. Asymmetric catalysis was used to synthesize two categories of polyketide natural products, cryptocaryols and tetrahydrolipstatin, in 25 and 10 longest linear steps, respectively. In addition, five cryptocaryol and eight tetrahydrolipstatin stereochemical analogues were also accessed, which demonstrated the versatility of the catalytic asymmetric approach. The asymmetric catalysis strategy is also applied to an ongoing project the total synthesis of EBC-23. These stereochemical analogues were used to develop structure activity relationship profiles for cryptocaryols and tetrahydrolipstatin cytotoxicity against cancer cell lines (e.g. MCF-7 and H460).
New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules
Author: Nicola Di Iorio
Publisher: Springer
ISBN: 3319749145
Category : Science
Languages : en
Pages : 173
Book Description
This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas. Organocatalysis is a relatively modern and “hot” topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism. Vinylogous systems are very important for their synthetic applications but also pose a number of challenges, the most notable of which are their reduced reactivity and the reduced stereocontrol at these positions. On the other hand, atropisomeric systems are even more important because of the huge potential they have as drugs, ligands and catalysts. Chemists have only recently “recognized” the importance of these two areas and are focusing their efforts on studying them and the challenges they pose. This thesis offers an extensive introduction on the general aspects of chirality and organocatalysis and an equally extensive experimental section that allow nonexperts to understand the discussion section and reproduce the experiments.
Publisher: Springer
ISBN: 3319749145
Category : Science
Languages : en
Pages : 173
Book Description
This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas. Organocatalysis is a relatively modern and “hot” topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism. Vinylogous systems are very important for their synthetic applications but also pose a number of challenges, the most notable of which are their reduced reactivity and the reduced stereocontrol at these positions. On the other hand, atropisomeric systems are even more important because of the huge potential they have as drugs, ligands and catalysts. Chemists have only recently “recognized” the importance of these two areas and are focusing their efforts on studying them and the challenges they pose. This thesis offers an extensive introduction on the general aspects of chirality and organocatalysis and an equally extensive experimental section that allow nonexperts to understand the discussion section and reproduce the experiments.
Asymmetric Catalysis
Author: B. Bosnich
Publisher: Taylor & Francis US
ISBN: 9789024732593
Category : Science
Languages : en
Pages : 176
Book Description
Proceedings of the NATO Advanced Research Workshop on Asymmetric Catalysis, Sanibel Island, Florida, USA, January 2-6, 1984
Publisher: Taylor & Francis US
ISBN: 9789024732593
Category : Science
Languages : en
Pages : 176
Book Description
Proceedings of the NATO Advanced Research Workshop on Asymmetric Catalysis, Sanibel Island, Florida, USA, January 2-6, 1984