Synthesis, Characterization, and Applications of Pyridine- and Pyridol-based Azamacrocyclic Transition Metal Complexes PDF Download
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Author: Hannah May Johnston
Publisher:
ISBN:
Category : Macrocyclic compounds
Languages : en
Pages : 298
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Book Description
Author: Hannah May Johnston
Publisher:
ISBN:
Category : Macrocyclic compounds
Languages : en
Pages : 298
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Book Description
Author: Kristof Pota
Publisher:
ISBN:
Category : Ligands (Biochemistry)
Languages : en
Pages : 0
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Book Description
Author: Magy Amir Maurice Mekhail
Publisher:
ISBN:
Category : Cyclophanes
Languages : en
Pages : 0
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Book Description
Pyridinophanes derived from pyclen are the focus of many studies as biological mimics, chelators, and catalytic precursors. Therefore, the desire to tune the reactivity of metal pyridinophane complexes has inspired modifications that include expansion of ring size and substitutions to the N-atoms. However, substitution on the pyridine moiety is largely unexplored to date. Herein, new synthetic strategies for pyclen-congeners bearing electron donating and electron withdrawing groups are introduced, resulting in doubling the number of pyridine functionalized molecules in literature. Further, the influence of such modifications on properties and reactivity of two metals (Fe(III) and Cu(II)) is described. For the Fe(III) system, 4-substitution of the pyridine ring successfully provides a regulatory handle on the electronic properties and the catalytic C-C coupling activity of the respective Fe complexes. These are the first examples of a structure-activity relationship study with the impact of electronic properties decoupled from structural properties and investigated. The Fe(III) system was also explored in a catalase mimetic study to determine the role of ligand design on the activity of the metal center through changing electronic properties and rigidity of the ligand. Varying the electronic properties of the ligand has a minor effect on catalase activity, but changes to the geometry of the complex have significant impacts on the system. This activity was also successfully observed to cellular models. The Cu(II) system was investigated as a superoxide dismutase mimic. Cu(II) Pyclen complexes, specifically, has been shown to match its coordination environment and to have high binding affinity. My studies highlight that modifications to the pyridine ring of the ligand can tune the redox potential, while exhibiting high binding stabilities and retaining the coordination environment. In fact, one of the complexes studied exhibits one of the highest SOD activities reported to date, which is hypothesized to be the result of not only the electronic properties of the Cu center but also the high binding stability exhibited by this complex. Altogether, this work focused on functionalizing the pyridine ring in pyridinophanes and studying the effect of the modifications on the electronics of metal complexes and their reactivity with both catalytic and potential therapeutic application.
Author: Frank L. Messana
Publisher:
ISBN:
Category :
Languages : en
Pages : 80
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Book Description
Author: Leonard F. Lindoy
Publisher: Cambridge University Press
ISBN: 052125261X
Category : Science
Languages : en
Pages : 281
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Book Description
This book contains an overview of complex formation by macrocyclic ligand systems. The study of macrocyclic chemistry represents a major area of activity which impinges on a range of other areas in both chemistry and biochemistry. The field has characteristically yielded many interesting and unusual compounds. The text discusses the structures and properties of macrocyclic compounds; the synthesis of macrocycles; polyether crown and related systems; metal-ion and molecular recognition (host-guest chemistry); as well as kinetic, thermodynamic and electrochemical aspects of a range of macrocyclic systems. A discussion of the different categories of naturally occurring macrocycles is also included. Specialist and non-specialist alike will find this a useful text. Apart from serving as a convenient reference for established workers in the field, it should also prove useful to new graduate students as well as to researchers from other areas who seek a general introduction to the subject. The topics discussed also provide a suitable basis for a senior undergraduate or graduate course in macrocyclic chemistry and inorganic complexes.
Author: Eike Bauer
Publisher: Springer
ISBN: 3319193961
Category : Science
Languages : en
Pages : 367
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Book Description
The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.
Author: Heinz-Bernhard Kraatz
Publisher: Wiley-VCH
ISBN:
Category : Science
Languages : en
Pages : 480
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Book Description
Destined to set the standard, this book meets the need for a didactic textbook focusing on the role of model systems in bioinorganic chemistry. The first part features concepts in bioinorganic chemistry such as electron transfer, medicinal inorganic chemistry, bioorganometallics and metal DNA complexes, while the second part presents inorganic model chemistry on metallo-enzymes, organized by metal ion. Experts in the pertinent fields provide a didactically well-organized background on relevant biological systems, as well as on their structural, functional and spectroscopic properties. All chapters are similarly structured, each one beginning with a timeline featuring the most important historical facts on the subject, followed by a table of the most significant enzymes. The authors also summarize key developments and open questions within the respective model systems. This book is aimed at senior undergraduate and graduate students in chemistry, biochemistry, life science and related fields.
Author: David J. Leggett
Publisher: Springer Science & Business Media
ISBN: 1468449346
Category : Science
Languages : en
Pages : 488
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Book Description
This volume is concerned with methods that are available for the calculation of for mation constants, in particular computational procedures. Although graphical meth ods have considerable value in the exploration of primary (raw) data they have been overtaken by computational methods, which, for the most part, take primary data and return the refined formation constants. Graphical methods are now considered com plementary to these general computational procedures. This volume brings together programs that span the lifetime of computer-assisted determination of formation constants. On one hand the reader will find listings of programs that are derived from LETAGROP (b.l961) and the GAUSS-G/SCOGS (b. 1962) families. On the other hand programs are presented that are the newest mem bers of the SCOGS lineage and from the on-going MINIQUAD series. One program is presented that describes a computational approach to the classical Hedstrom Osterberg methods; another that takes care of electrode calibration in a simple yet rigorous manner. Potentiometry and spectrophotometry are the most popular experimental tech niques for equilibrium studies, and the programs in this volume reflect this. Four programs handle potentiometric data, two will process spectrophotometric data, and one makes use of both types of data separately or in combination.
Author: Andre S. Merbach
Publisher: John Wiley & Sons
ISBN: 1118503678
Category : Science
Languages : en
Pages : 514
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Book Description
Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine
Author: Chris D. Geddes
Publisher: Springer
ISBN: 3319482602
Category : Medical
Languages : en
Pages : 361
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Book Description
Reviews in Fluorescence 2016, the tenth volume of the book serial from Springer, serves as a comprehensive collection of current trends and emerging hot topics in the field of fluorescence and closely related disciplines. It summarizes the year’s progress in fluorescence and its applications, with authoritative reviews specialized enough to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of fluorescence. Reviews in Fluorescence offers an essential reference material for any research lab or company working in the fluorescence field and related areas. All academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in the continuously emerging field of fluorescence will find it an invaluable resource.
