Synthesis and Characterization of Ruthenium (II) Polypyridyl Complexes PDF Download
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Author: Youxiang Wang
Publisher:
ISBN:
Category : Diazo compounds
Languages : en
Pages : 190
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Author: Youxiang Wang
Publisher:
ISBN:
Category : Diazo compounds
Languages : en
Pages : 190
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Book Description
Author: Colin R. Spencer
Publisher:
ISBN:
Category : Photochemistry
Languages : en
Pages : 588
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Author: Colin R. Spencer
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ISBN:
Category :
Languages : en
Pages :
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Eighteen polypyridyl ruthenium complexes were synthesized and characterized to test their ability to be new photodynamic compounds (PDCs). Each compound bears oxazo- or imidazo[4,5-f][1,10]phenanthroline ligands with a varying R-group and 2,2-bipyridine and 1,10-phenanthroline ancillary ligands. Biological tests were employed for the complexes to test the potential to be new PDCs, and included DNA photocleavage, DNA binding, and photocytotoxicity. Compounds containing thiophenes as the R-group showed significant DNA damage in the photocleavage assays as well as light toxicity and low dark toxicity in photocytotoxic assays. Compounds with 1,10-phenanthroline ancillary ligands generally showed more DNA photocleavage, unwinding, and binding compared to their 2,2'-bipyridine counterparts. Dinuclear compounds containing the bis(imidazo[4,5-f][1,10]phenanthroline) bridging ligand exhibited the best results for high light toxicity and low dark toxicity, the strongest binding to DNA, and the most potency for DNA photocleavage. As such these compounds are promising candidates for new PDCs and warrant further investigations.
Author: Sheau Yong Lau
Publisher:
ISBN:
Category : Ligands
Languages : en
Pages : 54
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Author: Sangsub Han
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Category :
Languages : en
Pages : 294
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Author: Mathew Stein
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Category : Metal complexes
Languages : en
Pages : 58
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Author: Youxiang Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 416
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Author: Carmen Kloer
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ISBN:
Category :
Languages : en
Pages : 0
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Author: Qiaoqin Zhao
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ISBN:
Category : Ruthenium
Languages : en
Pages : 192
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Author: Teresa Rapp
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Category :
Languages : en
Pages : 0
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Since its discovery in 1844, ruthenium has solidified its position as the most widely used transition metal in catalysis and excited state chemistry. Its lower toxicity and relatively low price (compared to other platinum group metals) have enabled many applications of ruthenium coordination compounds. In this dissertation I discuss ruthenium polypyridyl complexes that undergo photoinduced ligand exchange, and how this unique property can be harnessed to develop next-generation smart materials and responsive chemical biology tools. Ru(LL)2X22+ complexes, where LL is a bidentate aromatic heterocycle such as 2,2'-bipyridine, 1,10-phenanthroline, or 2,2'-biquinoline, and X is a pyridine-, nitrile-, sulfur-, or imidazole-based monodentate ligand, have the unique capability to undergo ligand exchange under visible light irradiation. We have harnessed this property to develop a series of visible-light-sensitive photodegradable crosslinkers by choosing X ligands that contain reactive moieties such as alkynes (for copper-mediated azide-alkyne cycloaddition (CuAAC)) or aldehydes (for Schiff base reaction with hydrazines). Ru(bpy)2(3-ethynylpyridine)2 (RuBEP) has been used in CuAAC reactions to circularize azide-terminated oligonucleotides important for gene regulation or transcriptome analysis. Ru(bpy)2 (3-pyridinaldehyde) 2 (RuAldehyde) alternately employed aldehydes to react with hydrazine-modified hyaluronic acid (HA-HYD). The resulting hydrogel was cytocompatible, efficiently degraded with visible light, and well adapted for the storage and delivery of active enzymes via lysine-mediated crosslinking into the hydrogel matrix. Finally, Ru(biq)2(5-hexynenitrile)2 and Ru(bpy) 2(5-hexynenitrile) 2 were developed as crosslinkers to form PEG-based hydrogel, which was subsequently degraded using two different colors of visible light, orange and blue.
