Author: Lovorka Degoricija
Publisher:
ISBN:
Category :
Languages : en
Pages : 424
Get Book Here
Book Description
Abstract: Dendrimers are well defined, highly branched macromolecules that consist of a core, internal branching units and a multitude of peripheral groups. Dendrimers possess low viscosities, high solubilities, single molecular weights, and a globular shape in solution. As a result, the architecture and physiochemical properties of dendrimers offer specific advantages over linear polymers. Currently, millions of people in the Unites States seek treatment for the repair of corneal wounds. The standard of care for repairing these wounds involves using sutures, which do not actively participate in healing of the surgical procedure. Another common medical problem involves the degradation of cartilage due to osteoarthritis or trauma. Since cartilage has a limited capacity for self-repair, the current methods of treatment involve the use of non-surgical and/or surgical techniques to reduce pain while maintaining joint function. Consequently, there is interest in synthesizing dendritic macromolecules specifically for these biomedical applications. Fourth generation, bola-type dendritic macromolecules were synthesized by the divergent method in an iterative process of monomer unit coupling, followed by deprotection. The design of these dendritic macromolecules was based on an ABA triblock architecture, wherein two dendritic arms, or A blocks, flanked a linear linker, or B block, via ester linkages. The dendritic arms consisted of biocompatible materials, while the linear linker was a non-immunogenic poly(ethylene glycol) of three different molecular weights. Degradation of these macromolecules leads to natural metabolites, such as succinic acid and glycerol, thus they are termed biodendritic macromolecules. The same synthetic strategy was used to prepare biodendritic macromolecules containing carbamate linkages, in addition to previous ester linkages, to obtain materials with a different set of physical properties. Further functionalization of these macromolecules was needed to prepare photocrosslinkable systems for the formation of hydrated networks, or hydrogels. Forming hydrogel networks from highly branched biodendritic macromers offers advantages in preparing hydrogels at low polymer concentration, varying mechanical properties, and developing in situ polymerizing systems for delivery to an irregularly shaped wound site. Consequently, hydrogels based on macromolecules possessing ester linkages were explored as sealants for corneal wounds, while scaffolds for cartilage repair were prepared from macromolecules containing carbamate linkages.
Author: Mingjun Liu
Publisher:
ISBN:
Category :
Languages : en
Pages : 358
Get Book Here
Book Description
Author: Michael Malkoch
Publisher:
ISBN:
Category :
Languages : en
Pages : 62
Get Book Here
Book Description
Author: Shamsudin
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Henrik Ihre
Publisher:
ISBN:
Category :
Languages : en
Pages : 72
Get Book Here
Book Description
Author: Fritz Vögtle
Publisher: Springer
ISBN: 3540465774
Category : Science
Languages : en
Pages : 317
Get Book Here
Book Description
The second volume on dendrimers is again written by pioneers in the field. Their contributions illuminate the aspects of dendrimers mentioned in the subtitle, and also touch on areas beyond chemistry, namely material sciences as well as biological, medicinal, analytical, and nano aspects.
Author: Anne-Marie Caminade
Publisher: CRC Press
ISBN: 135161729X
Category : Medical
Languages : en
Pages : 448
Get Book Here
Book Description
Dendrimers, which are hyperbranched synthetic macromolecules, have attracted researchers’ increasing interest over the last three decades owing to their numerous properties, in particular, in the fields of biology and nanomedicine. This book is an up-to-date collection of the most recent achievements in the use of dendrimers in nanomedicine, exemplified by phosphorus-containing dendrimers. Starting with the synthesis and characterization of phosphorus dendrimers, the book discusses their use as biomaterials, carriers of biological entities, and anti-inflammatory drugs; in bioimaging; and against prion diseases, Alzheimer’s, HIV, and cancer. It compares phosphorus dendrimers with other types of dendrimers. Supplemented with numerous references and abundant illustrations, the book opens new perspectives for the researchers working on dendrimers.
Author: John T. Landrum
Publisher: CRC Press
ISBN: 1420052314
Category : Medical
Languages : en
Pages : 562
Get Book Here
Book Description
Carotenoids are of great interest due to their essential biological functions in both plants and animals. However, the properties and functions of carotenoids in natural systems are surprisingly complex. With an emphasis on the chemical aspects of these compounds, Carotenoids: Physical, Chemical, and Biological Functions and Properties presents a b
Author: Vinod Kumar Yata
Publisher: Springer Nature
ISBN: 3030449254
Category : Technology & Engineering
Languages : en
Pages : 394
Get Book Here
Book Description
This book discusses the biological, technical and study-design challenges of Nanopharmaceuticals. Chapters of this book are dedicated to supermagentic iron oxide nanoparticles for the diagnosis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It also includes a brief introduction to magnetic resonance imaging and ends with the future prospective of iron oxide nanoparticles in cancer detection. The book also provides a critical discussion on ‘Computational sequence design for DNA nanostructures’ and gives a brief introduction about the skin delivery. A detailed discussion has been included about the different types of nanocarriers such as micells, microemulsions, nanoemulsions, polymeric and lipid based nanoparticles. Focussing on the safety concerns of nanomedicine it also covers the safety issues, clinical benefits, ecotoxicity and regulatory frame work of nanopharmaceuticals.
Author: Nina Dragicevic
Publisher: Springer
ISBN: 3662478625
Category : Medical
Languages : en
Pages : 387
Get Book Here
Book Description
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
