Synthesis and Biological Evaluation of 5-aminolevulinic Acid Derivatives for Improved Photodynamic Therapy PDF Download
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Author: Louis Mark-Antony Rogers
Publisher:
ISBN:
Category :
Languages : en
Pages : 221
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Book Description
Author: Louis Mark-Antony Rogers
Publisher:
ISBN:
Category :
Languages : en
Pages : 221
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Book Description
Author: Todd Simard
Publisher:
ISBN:
Category :
Languages : en
Pages : 92
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
N-terminal-blocked and N-terminal-free pseudotripeptide Gly-Gly and Gly-Pro derivatives of 5-aminolevulinic acid (ALA) esters were synthesized as potential specific substrates for cellular peptidases and precursors for the production of the photosensitizer protoporphyrin IX (PpIX). These precursors were evaluated using human cell lines of either carcinoma or endothelial origin. N-blocked or N-free dipeptides-ALA-ethyl esters, but not tripeptides-ALA-ethyl esters (or dipeptides-ALA-ethyleneglycols,) were substrates for cellular peptidases and were metabolized to ALA. The precursors were hydrolyzed intracellularly involving serine-proteases and metalloproteases. Cell selectivity for human endothelial or carcinoma cells was observed for some of these dipeptides-ALA. Thus drugs coupled to Gly-Gly-/Gly-Pro-derivatives may selectively target defined cells in human cancer, depending on specific cellular activating pathways expressed by the cells.
Author: Michael R. Hamblin
Publisher: Artech House
ISBN: 1596932783
Category : Medical
Languages : en
Pages : 601
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Book Description
With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.
Author: P. Calzavara-Pinton
Publisher: Elsevier
ISBN: 0080538843
Category : Science
Languages : en
Pages : 391
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Book Description
Photodynamic therapy has been widely investigated over the past two decades and is emerging as a promising therapeutic modality for skin cancers and several inflammatory diseases. This growing interest is based on the availability of a new simple, effective and safe regimen using the topical application of a pro-drug, 5-aminolevulinic acid, as well as on the development of new "second generation" photosensitizers, namely 5-aminolevulinic acid-esters, phthalocyanines, chlorins, porphycenes and hypericin. In contrast to hematoporphyrin derivatives, these compounds are characterized by short-lasting generalized skin photosensitivity. These dyes are available for either topical or systemic delivery and are well characterized. The basic principles of PDT is more complex than chemotherapy or other pharmacological modalities. PDT involves not only a drug but an otherwise harmless compound that is activated by visible light. The interaction of these two treatment components is PDT. The variability of these both components results in a complexity of the treatment that may disorient the clinician who does not have specific experience in this field. This book aims to focus experimental and clinical findings on PDT in order to attract and direct the attention of a growing number of dermatologists.
Author: Tebello Nyokong
Publisher: Springer Science & Business Media
ISBN: 9048138728
Category : Science
Languages : en
Pages : 672
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Book Description
This book addresses the synthesis of photosensitizers, the main emphasis being on the new methods of synthesis such as microwave, sonochemistry and the use of ionic liquids. It also addresses the photochemistry and photophysics of the photosensitizers alone and in combination with nanoparticles, the use of the photosensitizers in environmental control, safety and medicine. It discusses the common structures of the photosensitizers which are beneficial to these applications.
Author: Mark Wainwright
Publisher: John Wiley & Sons
ISBN: 0470744944
Category : Science
Languages : en
Pages : 296
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Book Description
Photosensitisers in Biomedicine offers clear and comprehensive coverage of the many different photosensitiser types, including information on their many applications that now extend beyond anticancer therapy. These applications now include photoantimicrobial treatments not only in microbial disease, but also in the microbial resistance to conventional drugs, which is circumvented by photomicrobial action. The application of photoantimicrobials in biological fluids is also of considerable importance in the current era of HIV and is discussed in the book. This text offers the most up-to-date coverage of photodynamic therapy including information on how photosensitisers have evolved within the field of cancer therapy and more recently antimicrobial research. There are few books on the market that take the approach of this text, as many are either conference based or focus on the chemistry of photosensitisers. Photosensitisers in Biomedicine is clearly defined into three distinct parts beginning with a clear introduction to the various types of photosensitisers. The book then moves on to discuss the chemistry of photosensitisers and closes with their numerous applications, for example, photodynamic therapy, photodiagnosis, photodynamic antimicrobial chemotherapy (PACT) and other non-oncological applications such as optical, arterial plaques and stents.
Author: Michael H. Gold
Publisher: Springer Science & Business Media
ISBN: 1441912983
Category : Medical
Languages : en
Pages : 209
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Book Description
Photodynamic therapy is a proven effective treatment of actinically damaged skin cells, nonmelanoma skin cancers, and acne and other pilosebaceous conditions. As an agent for general facial rejuvenatin it has untapped potential. The current state of PDT therapy and future applications are discussed in detail in this exciting new volume. Throughout, the focus is on evidence-based clinical uses of PDT, including pretreatment regimens, avoidance and management of complications, and posttreatment suggestions.
Author: Jaspreet Singh Kochhar
Publisher: Springer
ISBN: 3030154440
Category : Medical
Languages : en
Pages : 156
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Book Description
This monograph covers a novel technology to deliver drugs and cosmetics through the skin in a minimally invasive manner. Microneedles – a bed of miniaturized needles is one of the most studied topics in delivering actives through the skin barrier. This book enables readers to understand the delivery of ingredients through the skin, describes a novel and simple method to fabricate microneedles containing a range of small and large molecular weight compounds, studies their physical properties as well as delivery through the skin layers. Readers will discover this book to be extremely beneficial to help them understand the state of the field of transdermal drug delivery, with extensive coverage including experimental data on basics of microneedle fabrication technology using photolithography, encapsulation of drugs within the polymeric matrix of microneedles and studying their release patternsin vitro and ex vivo . Academic researchers, pharmaceutical and cosmeceutical industry as well as students of skin science will find this account very useful in their pursuits. As microneedles grow and develop into a commercial reality with more actives being delivered and significant clinical research being put in, this account will hold well in providing basic principles and knowledge together with rigorous experimental data.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 762
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Book Description
Theses on any subject submitted by the academic libraries in the UK and Ireland.
