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Author: Stephen D. Meriney
Publisher: Academic Press
ISBN: 0128153210
Category : Medical
Languages : en
Pages : 530
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Book Description
Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. - Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission - Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles - Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic
Author: Stephen D. Meriney
Publisher: Academic Press
ISBN: 0128153210
Category : Medical
Languages : en
Pages : 530
Get Book Here
Book Description
Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. - Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission - Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles - Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic
Author: Jacques Fantini
Publisher: Academic Press
ISBN: 0128004924
Category : Medical
Languages : en
Pages : 398
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Book Description
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. - Written to provide a "hands-on" approach for readers - Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings - Step-by-step guide to memorize and draw lipid structures - Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
Author: Rodolfo Riascos Llinás
Publisher: Oxford University Press, USA
ISBN: 9780195116526
Category : Neural transmission
Languages : en
Pages : 234
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Book Description
Ideal for graduate and undergraduate courses, the book includes PC and Macintosh versions of two programs for simulating and manipulating any aspect of synaptic transmission."--BOOK JACKET.
Author: Jeffrey Noebels
Publisher: OUP USA
ISBN: 0199746540
Category : Medical
Languages : en
Pages : 1258
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Book Description
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author: Hugo J. Bellen
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 466
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Book Description
This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
Author: Wulfram Gerstner
Publisher: Cambridge University Press
ISBN: 1107060834
Category : Computers
Languages : en
Pages : 591
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Book Description
This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
Author: Johannes W. Hell
Publisher: Springer Science & Business Media
ISBN: 0387772324
Category : Medical
Languages : en
Pages : 801
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Book Description
This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse’s functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It’s an important text for neuroscientists and disease-oriented clinicians in neurology.
Author: Neurosciences Institute (New York, N.Y.)
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 808
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Book Description
This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important relationship of transmitter diversity and synaptic types to the behavior of actual cellular networks. All of the studies described in these sections point to the necessity of considering interactions between anatomy, chemistry, physiology and pharmacology if synaptic function is to be understood at any one of these levels of analysis.
Author: Elliot S. Valenstein
Publisher: Columbia University Press
ISBN: 0231135882
Category : Computers
Languages : en
Pages : 257
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Book Description
The question of how nerves communicate with one another was the subject of a heated & protracted dispute between pharmacologists & neurophysiologists. This book recalls the debate & how the theory of chemical transmission was eventually confirmed by the discovery of neurotransmitters.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309212219
Category : Medical
Languages : en
Pages : 74
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Book Description
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
