Sustained and Controlled Release Drug Delivery Systems PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Sustained and Controlled Release Drug Delivery Systems PDF full book. Access full book title Sustained and Controlled Release Drug Delivery Systems by Joseph R. Robinson. Download full books in PDF and EPUB format.
Author: Joseph R. Robinson
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 808
Get Book Here
Book Description
Author: Joseph R. Robinson
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 808
Get Book Here
Book Description
Author: Leon Shargel
Publisher: McGraw-Hill/Appleton & Lange
ISBN: 9780838502396
Category : Biopharmaceutics
Languages : en
Pages : 625
Get Book Here
Book Description
Author: Subrata Bhadra
Publisher: GRIN Verlag
ISBN: 3656475849
Category : Medical
Languages : en
Pages : 135
Get Book Here
Book Description
Master's Thesis from the year 2010 in the subject Medicine - Pharmacology, Pharmacy, University of Dhaka (M. Pharm, in Pharmaceutical Technology), language: English, abstract: The aim of the present studies was to develop and characterize 2.6 mg sustained release matrix tablets of Nitroglycerin. Tablets were prepared by direct compression method. Methocel K15M CR and Methocel K100LV CR polymers were used as rate retarding agents in nine formulations (F-1 to F-9). The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, Carr’s index, Hausner ratio, moisture content, total porosity and assay. The tablets were subjected to diameter, thickness, assay, uniformity of content, assay after 1Month at 40°C+75%RH, hardness, friability, and in vitro dissolution studies. The granules showed satisfactory flow properties, compressibility, and drug content. All the tablet formulations showed acceptable pharmacotechnical properties and complied with pharmacopoeial specifications for tested parameters. The in vitro dissolution study was carried out for 8 hour using USP-2009 Apparatus-I (Rotating basket method) in distilled water as the dissolution medium. The release mechanisms were explored and explained by Zero order, First order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell equations. Nine formulations were prepared by using three variable ratio of two polymers; Methocel K15M CR (25%, 20% and 15%) and Methocel K100LV CR (15%, 10% and 5%) where all the formulations (F-1 to F-9) contained 0.5% colloidal silicon dioxide and 1% magnesium stearate. Among these nine formulations, six formulations; F-2 (Methocel K15M CR: Methocel K100LV CR = 25% : 10%), F-3 (Methocel K15M CR : Methocel K100LV CR = 25% : 5%), F-4 (Methocel K15M CR : Methocel K100LV CR = 20% : 15%) F-5 (Methocel K15M CR: Methocel K100LV CR = 20% : 10%), F-6 (Methocel K15M CR : Methocel K100LV CR = 20% : 5%) and F-7 (Methocel K15M CR : Methocel K100LV CR = 15% : 15%) met the official specification of release profile. It was also found that the type and the amount of polymers significantly affect the time required for 50% (T50% or MDT) of drug release, release rate constant and diffusion exponent. Higher the MDT value indicates a higher drug retaining capacity of the polymers and vice-versa. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism of all proposed formulations followed anomalous type or non-Fickian transport (n>0.43 and n
Author: Dilip M. Parikh
Publisher: CRC Press
ISBN: 1000366383
Category : Medical
Languages : en
Pages : 905
Get Book Here
Book Description
Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies
Author: Clive G. Wilson
Publisher: Springer Science & Business Media
ISBN: 1461410045
Category : Medical
Languages : en
Pages : 415
Get Book Here
Book Description
Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Author: Hong Wen
Publisher: John Wiley & Sons
ISBN: 1118060326
Category : Science
Languages : en
Pages : 571
Get Book Here
Book Description
This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.
Author: Alan A Marchiondo
Publisher: Academic Press
ISBN: 9780128014493
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
Pyrantel Parasiticide Therapy in Humans and Domestic Animals presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes. Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970's to control two important nematode groups, the hookworms and the roundworms. Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.
Author: Mohammad Asadujjaman
Publisher: LAP Lambert Academic Publishing
ISBN: 9783844319026
Category :
Languages : en
Pages : 88
Get Book Here
Book Description
The rate at which a drug is released from a resinate is dependent on many factors. In many cases the rate is sufficiently slow that the resulting effect is an extended or sustained release over many hours.Further modification can be achieved by the use of coatings that restrict the release, or control the site of release.Examples of drugs where this technique is currently used include dextromethorphan(coated),diclofenac, and nicotine. The resinate will be a solid, with similar characteristics to the original ion exchange resin powder and, as such, can be formulated into any of the traditional solid dosage forms.Time Release Technology also known as Sustained-release (SR), extended-release (ER, XR, or XL), time-release or timed-release, controlled-release (CR), or continuous-release (CR or Contin) pills are tablets or capsules formulated to dissolve slowly and release a drug over time. The advantages of sustained-release tablets or capsules are that they can often be taken less frequently than instant-release formulations of the same drug, and that they keep steadier levels of the drug in the bloodstream
Author: Michael R. Clarkson
Publisher: Elsevier Health Sciences
ISBN: 1455703788
Category : Medical
Languages : en
Pages : 928
Get Book Here
Book Description
Pocket Companion to Brenner and Rector’s The Kidney distills the essential clinical information from the latest edition of the seminal text on kidney diseases and their management. Michael R. Clarkson, Ciara Magee, and Barry M. Brenner detail the key pathophysiologic, diagnostic, and treatment issues in clinical nephrology, including interventional nephrology, endocrine aspects of kidney disease, and plasmapheresis. Diagnose, treat, and manage both common and uncommon disorders. Find clinical knowledge quickly and easily thanks to convenient tables throughout the text. Choose the best option of the many techniques available through discussions of indications for laboratory tests and imaging studies. Enhance your clinical acumen with coverage of new topics such as risk factors and kidney disease, nephron endowment, interventional nephrology, plasmapheresis, xenotransplantation, stem cells in renal biology and medicine, and more. Stay current thanks to two new sections—Epidemiology and Risk Factors in Kidney Disease and Frontiers in Kidney Disease—that include topics such as stem cell and genomics.
Author: Raymond S. Sinatra
Publisher: Cambridge University Press
ISBN: 1139491989
Category : Medical
Languages : en
Pages : 551
Get Book Here
Book Description
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
