Sulfur-based Reactive Species in Chemistry and Biology PDF Download
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ISBN:
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Languages : en
Pages : 400
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 400
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Book Description
Author: John P Toscano
Publisher: Mdpi AG
ISBN: 9783036591209
Category :
Languages : en
Pages : 0
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Book Description
Hydrogen sulfide (H2S) is a naturally occurring signaling molecule produced in vivo and plays a pivotal role in regulating a wide array of physiological processes. Additionally, emerging findings have illuminated that many of the biological effects initially attributed to H2S may actually stem from other reactive sulfur species (RSS), including hydropersulfides (RSSH) and various higher-order polysulfur species (RSSnH, RSSnR, and HSnH, where n > 1). These studies have underscored the contributions of these species to essential cellular processes, such as the efficient scavenging of reactive oxygen species and electrophiles, and their influence on mitochondrial function. Nonetheless, the chemistry of RSS remains challenging due to their inherently reactive nature, and their precise measurement within biological systems continues to pose a formidable challenge. This compilation of reprints focuses on recent advancements in the field of H2S/RSS chemical biology. It encompasses original research studies and comprehensive reviews, all geared towards exploring the therapeutic potential of H2S/RSS donors in the treatment of various conditions, including cancer, neurological disorders, and cardiovascular disease. Furthermore, it delves into the molecular mechanisms and physiological roles played by RSS along with the development of methodologies for quantifying and measuring the distribution of RSS within biological systems.
Author: C. Chatgilialoglu
Publisher: Springer Science & Business Media
ISBN: 1468458744
Category : Science
Languages : en
Pages : 448
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Book Description
A wonderfully successful NATO Advanced Study Institute on "Sulfur-Centered Reactive Intermediates in Chemistry and Biology" was held 18-30 June, 1989, at the Hotel Villa del Mare in Maratea, Italy. Despite the beautiful setting with mountains behind us and over looking the clear blue Mediterranean Sea under a cloudless sky (and with a private beach available), the lectures were extremely well attended. While some credit can go to the seriousness of the students, more must go to the calibre of speakers and the high quality of C. Chatgilialoglu, and Co-Director, Professor K. -D. their presentations. The Director, Dr. Asmus, are to be congratulated for putting together such an outstanding scientific program. Dr. Chatgilialoglu is also to be commended for arranging an equally stimulating social pro gram which included bus, train and boat trips to many local sites of interest. It was particularly fitting that a meeting on the chemistry and biochemistry of sulfur should be held in Italy since Italian chemists have made major contributions to our under standing of the organic chemistry of sulfur, including the chemistry of its reactive inter mediates. The early Italian interest in sulfur chemistry arose from the fact that Italy, or more specifically, Sicily, was a major world producer of sulfur prior to the development and exploitation of the Frasch process in Texas and Louisiana.
Author: Santiago I. Suarez
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Two decades of research on the signaling capacity of hydrogen sulfide (H2S) in biological systems has led to parallel investigations of other reactive sulfur species (RSS) such as persulfides (RSSH) and polysulfides (RSS[subscript n]R, n>1). The purpose of this dissertation was to develop and assess new investigative tools that selectively detect or effectively deliver RSS under biologically relevant conditions. These chemical tools are of significant interest to the redox and molecular signaling communities and can be used to further define the prevalence, signaling capacity, and therapeutic effects of RSS, representing a significant advancement within the field. In chapter II, we describe the design, synthesis, and examination of an innovative, reaction-based fluorescent probe that exploits the double nucleophilic character of H2S by undergoing an intramolecular cyclization to release a fluorescent reporter. Specifically, we employed a highly unique selenosulfide moiety as a trigger for H2S detection. Given the distinct chemical differences between selenium and sulfur, we reasoned that the selenium half would provide access to chemical probes with high reactivity towards and selectively for H2S. Meanwhile, a suitable handle for improving the physicochemical properties of the probe, including its water solubility, cell permeability, and tissue specificity, could be supplied by the sulfide half. Using this novel design strategy, we successfully produced and assessed two H2S-selective probes: AL1, which displayed good water solubility, cell permeability, and overall biocompatibility, and AL2, which displayed cancer cell specificity. Concomitant to detection, chapter III discusses the synthesis and application of a self-reporting donor (ZL47), sensitive to reactive oxygen species (ROS). To accomplish this, we appended an aryl boronate ester to 7-hydroxycoumarin via an S-alkyl thiocarbonate linker allowing for the simultaneous release of COS, an H2S precursor, and a fluorescent reporter in response to hydrogen peroxide. In addition, we determined that ZL47 was a useful bifunctional tool with an ability to both image and alleviate oxidative stress in live cells, highlighting its potential as a theranostic. Chapter IV describes a novel ROS-activated persulfide donor (RAH393) that operates through a unique mechanistic pathway that avoids the production of a 1,4-quinone methide as a toxic byproduct, a major setback for ZL47 and related donors that employ a 1,6-elimination. In addition to confirming that its lactone byproduct was nontoxic, we were able to demonstrate the impressive cellular protection provided by RAH393 against high concentrations of ROS in live HeLa cells. Because this donor proved to be a valuable tool for generating persulfides in response to ROS, in chapter V, we investigated the therapeutic effects of an analogue that targets mitochondria (Mito-PD), the primary producers of ROS and a known site of RSS oxidation. To accomplish this, the mixed disulfide of RAH393 was modified and equipped with a lipophilic cation to facilitate mitochondrion uptake. Using confocal laser microscopy, we confirmed Mito-PD’s preferential release of persulfides within mitochondria from co-localization studies using AL1 (an H2S-selctive probe) and Mitotracker Red. In addition, we demonstrated that Mito-PD protects cardiomyoblast cells in culture (H9C2) from doxorubicin (DOX)-induced cardiotoxicity. Subsequent studies with JC-1, a fluorescent probe that reports on mitochondrial membrane potential, indicate that Mito-PD effectively preserves the membrane potential of DOX treated cells, increasing their viability. These initial studies highlight the therapeutic benefits of mitochondria-targeting RSS donors and their potential for mitigating DOX-induced cardiotoxicity.
Author: Christopher S. Kovacs
Publisher: Academic Press
ISBN: 0128148241
Category : Medical
Languages : en
Pages : 1038
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Book Description
Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management systematically examines the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This reference volume expands coverage of specific disorders and diseases beyond the current endocrinology content on the market, which in most cases has a paragraph or no mention at all about pregnancy or aspects of fetal/neonatal development. Formalized source of maternal/fetal endocrine physiology and pathophysiology Key reference for fellows and residents for rarer endocrine pathologies Integrated presentation of new molecular and genetic causes of endocrine disorders Bridges the experience/knowledge gap of endocrinopathies rarely encountered in pregnancy
Author:
Publisher: Academic Press
ISBN: 012801623X
Category : Science
Languages : en
Pages : 351
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Book Description
These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field Covers conventional and new hydrogen sulfide detection methods Covers the pharmacological activity of hydrogen sulfide donors Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation
Author: Rüdiger Hell
Publisher: Springer Science & Business Media
ISBN: 1402068638
Category : Science
Languages : en
Pages : 539
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Book Description
Sulfur is one of the most versatile elements in life. This book provides, for the first time, in-depth and integrated coverage of the functions of sulfur in phototrophic organisms including bacteria, plants and algae. It bridges gaps between biochemistry and cellular biology of sulfur in these organisms, and of biology and environments dominated by them. The book therefore provides a comprehensive overview of plant sulfur relations from genome to environment.
Author: Richard Folkson
Publisher: Woodhead Publishing
ISBN: 0323900283
Category : Technology & Engineering
Languages : en
Pages : 800
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Book Description
Alternative Fuels and Advanced Vehicle Technologies for Improved Environmental Performance: Towards Zero Carbon Transportation, Second Edition provides a comprehensive view of key developments in advanced fuels and vehicle technologies to improve the energy efficiency and environmental impact of the automotive sector. Sections consider the role of alternative fuels such as electricity, alcohol and hydrogen fuel cells, as well as advanced additives and oils in environmentally sustainable transport. Other topics explored include methods of revising engine and vehicle design to improve environmental performance and fuel economy and developments in electric and hybrid vehicle technologies. This reference will provide professionals, engineers and researchers of alternative fuels with an understanding of the latest clean technologies which will help them to advance the field. Those working in environmental and mechanical engineering will benefit from the detailed analysis of the technologies covered, as will fuel suppliers and energy producers seeking to improve the efficiency, sustainability and accessibility of their work. Provides a fully updated reference with significant technological advances and developments in the sector Presents analyses on the latest advances in electronic systems for emissions control, autonomous systems, artificial intelligence and legislative requirements Includes a strong focus on updated climate change predictions and consequences, helping the reader work towards ambitious 2050 climate change goals for the automotive industry
Author:
Publisher: Academic Press
ISBN: 0128211520
Category : Science
Languages : en
Pages : 432
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Book Description
Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Optical Imaging and Conjugation, Volume 639, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Fluorogenic detection of protein aggregates in live cells using the AggTag method, Synthesis and Application of Ratiometric Probes for Hydrogen Peroxide Detection, Chemical Tools for Multicolor Protein FRET with Tryptophan, Fluorescing Isofunctional Ribonucleosides for Adenosine Deaminase Activity and Inhibition, Temporal profiling establishes a dynamic S-palmitoylation cycle, Solvation-guided design of fluorescent probes for discrimination of amyloids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Author: Ruma Banerjee
Publisher: John Wiley & Sons
ISBN: 9780470177327
Category : Science
Languages : en
Pages : 350
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Book Description
This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students.
