Studies Toward the Total Synthesis of Quartromicin PDF Download
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Author: Jun Qi
Publisher:
ISBN: 9780542922879
Category :
Languages : en
Pages : 114
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Book Description
The quartromicins are a group of structurally complex macrocyclic natural products that display activity against herpes simplex virus type 1 (HSV-1), influenza, and HIV. The quartromicins contain four spirotetronate subunits (two endo and two exo spirotetronates) connected in an alternating head to tail manner. While previous synthetic studies in the Roush laboratory have led to the development of an efficient pathway to the endo spirotetronate subunits, the synthesis of the exo spirotetronate subunits has remained much more challenging.
Author: Jun Qi
Publisher:
ISBN: 9780542922879
Category :
Languages : en
Pages : 114
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Book Description
The quartromicins are a group of structurally complex macrocyclic natural products that display activity against herpes simplex virus type 1 (HSV-1), influenza, and HIV. The quartromicins contain four spirotetronate subunits (two endo and two exo spirotetronates) connected in an alternating head to tail manner. While previous synthetic studies in the Roush laboratory have led to the development of an efficient pathway to the endo spirotetronate subunits, the synthesis of the exo spirotetronate subunits has remained much more challenging.
Author: Roxanne Kay Kunz
Publisher:
ISBN:
Category :
Languages : en
Pages : 272
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Author: Samuel William Gerritz
Publisher:
ISBN:
Category :
Languages : en
Pages : 376
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Author: Evan Adam Hecker
Publisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 542
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Book Description
Herein is described our work towards the total synthesis of the marine natural product (")-chartelline C and the potent antibiotic ( - )-platensimycin. Part 1 relates the (")-chartelline C project. The first chapter reviews (")-chartelline C's isolation, biogeneity, and previously reported studies relevant to the area. Chapter 2 tells of our contributions including the development of a convergent, regioselective assembly of an indole-imidazole compound en route to the natural product. Chapter 3 includes the experimental details of this work and the characterization of previously unreported compounds. Part 2 recounts the ( - )-platensimycin research project. Chapter 4 discusses the importance of the natural product and the relevant previous research reported. Chapter 5 describes our efforts in this area, culminating in the stereoselective synthesis of an intermediate closely related to a known compound, which was converted to the natural product. Chapter 6 includes the experimental details of this work and the characterization of previously unreported compounds.
Author: Tracy Stark
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 310
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Author: Lok-Lok Liu
Publisher:
ISBN: 9781361255162
Category :
Languages : en
Pages :
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This dissertation, "Studies Toward the Total Synthesis of ( )-cortistatin J via an Intramolecular (4 3) Cycloaddition" by Lok-lok, Liu, 廖樂樂, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4659162 Subjects: Ring formation (Chemistry) Organic compounds - Synthesis
Author: Brian B. Filippini
Publisher:
ISBN:
Category :
Languages : en
Pages : 828
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Author: Jonathan Richard Scheerer
Publisher:
ISBN:
Category : Organic compounds
Languages : en
Pages : 412
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Alison Hawkins
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ISBN:
Category :
Languages : en
Pages :
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