Studies Directed Toward the Synthesis of Paclitaxel Analogs PDF Download
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Author: Thomas E. Janini
Publisher:
ISBN:
Category : Paclitaxel
Languages : en
Pages : 532
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Book Description
Author: Thomas E. Janini
Publisher:
ISBN:
Category : Paclitaxel
Languages : en
Pages : 532
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Book Description
Author: Pauline McDonald Hamilton
Publisher:
ISBN:
Category : Cytochemistry
Languages : en
Pages : 164
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Author: Christopher Fairman Claiborne
Publisher:
ISBN: 9780591099461
Category : Aromatic compounds
Languages : en
Pages : 886
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Book Description
Model studies were carried out on key steps directed toward a synthesis of taxol. A model aromatic taxol C ring was coupled to taxol A ring via the Shapiro reaction. Selective functionalization of the A ring was carried out by epoxidation of the allylic alcohol derived from Shapiro coupling. Compatible protecting groups were found to rigidity the model AC framework in preparation for cyclization of the B ring. The McMurry reaction was established as an effective method for the formation of the eight membered B ring. Selective functionalization of the C-13 position of the A ring by PCC oxidation was accomplished. Controlled reduction of the C-13 ketone was carried out and subsequent coupling to the taxol side chain was achieve by the Oijima-Holton method. A biologically active analog of taxol was synthesized. Toward a synthesis of a brevetoxin B analog, a model ABC ring fragment was synthesized by established 6 -endo hydroxy-epoxide cyclizations. A model EF ring system was also synthesized by similar methods. Variations on the ABC fragment were independently coupled to the FG fragment and in a novel titanium mediated metathesis, the D ring was formed. Functionalization of the resulting D ring enol ether set the stage for the formation of the E ring via a hydroxy-ketone condensation. A hexacyclic (B - G) and heptacyclic (A - G) fused polyether ring systems were synthesized during our efforts to prepare a brevetoxin B analog.
Author: James Giles Tarrant
Publisher:
ISBN:
Category : Paclitaxel
Languages : en
Pages : 604
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Author: Jeffrey N. Johnston
Publisher:
ISBN:
Category :
Languages : en
Pages : 596
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Author: Robert Kenneth Griffith
Publisher:
ISBN:
Category : Mercaptocyclopropylamines
Languages : en
Pages : 190
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Author: Gabriel N. Kapur
Publisher:
ISBN: 9781109844450
Category :
Languages : en
Pages : 259
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Book Description
The northern hemisphere, which had been previously synthesized in our labs, was closely analyzed and synthesized again, with an improvement in the final three steps so that a more isomerically pure product resulted (15:1 now vs. 3:1 before). Finally, a crucial Suzuki coupling reaction of the northern and southern hemispheres was performed, which allowed the diol moiety at C19 and C20 to remain unprotected. This was followed by a saponification reaction to bring us to a very advanced carboxylic acid intermediate, one step from the closed 20-membered macrocycle.
Author: Matthew Suffness
Publisher: CRC Press
ISBN: 9780849383823
Category : Medical
Languages : en
Pages : 444
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Book Description
This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309168392
Category : Science
Languages : en
Pages : 238
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Book Description
Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Author: Gordon M. Cragg
Publisher: CRC Press
ISBN: 1420039652
Category : Medical
Languages : en
Pages : 610
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Book Description
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
