Structure-function Relationships of E. Coli Aminoacyl-tRNA Synthetases PDF Download
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Author: Patricia D. Youngblood
Publisher:
ISBN:
Category : Transfer RNA.
Languages : en
Pages : 56
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Book Description
Author: Patricia D. Youngblood
Publisher:
ISBN:
Category : Transfer RNA.
Languages : en
Pages : 56
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Michael Ibba
Publisher: CRC Press
ISBN: 9781587061899
Category : Science
Languages : en
Pages : 0
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Book Description
By virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code.
Author: Kirklen John Kupecz
Publisher:
ISBN:
Category : Nucleoproteins
Languages : en
Pages : 382
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Book Description
Author:
Publisher: Academic Press
ISBN: 0080921639
Category : Science
Languages : en
Pages : 334
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Book Description
By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Author: John Walker Roberts
Publisher:
ISBN:
Category : Escherichia coli
Languages : en
Pages : 228
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Author: Jack Chia-Hsiang Liu
Publisher:
ISBN:
Category :
Languages : en
Pages : 236
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Book Description
The relationship of E. coli tRNA[superscript Val] structure to its function in the aminoacylation reaction and the later steps of polypeptide synthesis was investigated. Steady-state kinetic studies of the aminoacylation of in vitro transcribed tRNA[superscript Val] variants have shown that nucleotides, A35, C36, A73, and G20, are important for the specific recognition of E. coli tRNA[superscript Val] by valyl-tRNA synthetase (ValRS). Identity swap experiments, testing the efficiency of this "recognition nucleotide set" in converting yeast tRNA[superscript Phe] and E. coli tRNA[superscript Phe] into valine into valine acceptors, confirm the importance of the recognition nucleotide set. In addition, a minor recognition nucleotide, G45, was also identified. Furthermore, our results indicate that VALRS requires an undistorted A-form helix in the acceptor stem for efficient aminoacylation of a TRNA substrate. In a study of the universally conserved 3'-CCA sequence of tRNA[superscript Val], our laboratory has shown that the 3'-CCA is not essential for all functions.
Author: Dieter Söll
Publisher:
ISBN: 9781555818333
Category : Aminoacyl-tRNA synthetases
Languages : en
Pages : 572
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128202610
Category : Science
Languages : en
Pages : 440
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Book Description
Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series
Author: for the National Academy of Sciences
Publisher: National Academies Press
ISBN: 0309552672
Category : Science
Languages : en
Pages : 336
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Book Description
Since George Gaylord Simpson published Tempo and Mode in Evolution in 1944, discoveries in paleontology and genetics have abounded. This volume brings together the findings and insights of today's leading experts in the study of evolution, including Ayala, W. Ford Doolittle, and Stephen Jay Gould. The volume examines early cellular evolution, explores changes in the tempo of evolution between the Precambrian and Phanerozoic periods, and reconstructs the Cambrian evolutionary burst. Long-neglected despite Darwin's interest in it, species extinction is discussed in detail. Although the absence of data kept Simpson from exploring human evolution in his book, the current volume covers morphological and genetic changes in human populations, contradicting the popular claim that all modern humans descend from a single woman. This book discusses the role of molecular clocks, the results of evolution in 12 populations of Escherichia coli propagated for 10,000 generations, a physical map of Drosophila chromosomes, and evidence for "hitchhiking" by mutations.
