Author: World Health Organization
Publisher: World Health Organization
ISBN: 924006026X
Category : Medical
Languages : en
Pages : 102
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Book Description
The Strategy to respond to antimalarial drug resistance in Africa is a technical and advocacy document, grounded in the best available evidence to date and aimed at minimizing the threat and impact of antimalarial drug resistance of Plasmodium falciparum parasites in Africa. Its objectives are to: i) improve the detection of resistance to ensure a timely response; ii) delay the emergence of resistance to artemisinin and artemisinin-based combination therapy (ACT) partner drugs; and iii) limit the selection and spread of resistant parasites where resistance has been confirmed.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240095292
Category : Medical
Languages : en
Pages : 36
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Book Description
On 4, 5 and 7 March 2024, the WHO Malaria Policy Advisory Group (MPAG) convened in Yaoundé, Cameroon, to review updates and progress, and to provide guidance on thematic areas of work by the Global Malaria Programme. The meeting focused on the following topics: malaria vaccine introduction and scale-up, and the Gavi-supported malaria learning agenda; the High burden to high impact (HBHI) approach; subnational tailoring; biological threats to vector control in Africa; the strategy to respond to antimalarial drug resistance in Africa; the development of guidelines recommendations on tafenoquine, primaquine and near-patient glucose-6-phosphate dehydrogenase (G6PD) diagnostic tests to support radical cure of Plasmodium vivax; and malaria elimination, including zoonotic malaria.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240103600
Category : Medical
Languages : en
Pages : 38
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Book Description
Effective malaria case management requires quick access to diagnostics and antimalarial treatments to reduce illness and death. Artemisinin-based combination therapy (ACT) has been essential to malaria treatment since 2001, as it combines artemisinin for rapid parasite reduction with a partner drug to ensure complete cure. However, resistance to antimalarial drugs, where parasites survive standard doses, threatens malaria control. Partial resistance to artemisinin, linked to Pfkelch13 mutations, has recently emerged in several African countries, leading to slower parasite clearance times. Artemisinin partial resistance does not lead to ACT failure where the partner medicines are still effective. However, additional resistance to partner drugs would jeopardize ACT effectiveness. To address this threat, WHO launched a 2022 strategy to respond to drug resistance in Africa. This strategy aims to improve detection, enable timely responses, and reduce resistance impact through evidence-based measures. The strategy with 20 approaches includes the measures such as multiple first-line therapies (MFT) to extent the therapeutic useful life of the ACTs. This implementation guide providing guidance for malaria programmes by defining MFT, reviewing MFT’s impact on resistance, assessing implications for policy and implementation and identifying evidence gaps for future research.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240064893
Category : Medical
Languages : en
Pages : 372
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Book Description
Each year, WHO’s World malaria report offers in-depth information on the latest trends in malaria control and elimination at global, regional and country levels. The report highlights progress towards global targets and describes opportunities and challenges for curbing and eliminating the disease. This year’s report includes three new sections on: (1) global and regional initiatives launched in 2021 and 2022; (2) global malaria surveillance and country-level case studies on surveillance systems assessments; and (3) research and development. The report also includes an expanded section on threats to malaria control, with a focus on the declining effectiveness of insecticide-treated mosquito nets.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240074384
Category : Medical
Languages : en
Pages : 29
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Book Description
On 18–20 April 2023, the WHO Malaria Policy Advisory Group (MPAG) convened to review updates and progress, and to provide guidance on thematic areas of work by the Global Malaria Programme. The meeting focused on the following topics: 1) the RBM Partnership to End Malaria evaluation of the “High burden to high impact” (HBHI) approach; 2) updates on the vector control, treatment and diagnostic recommendations in the WHO guidelines for malaria; 3) revisiting comparative effectiveness in the context of the arrival of new vector control products; 4) an update on certification of malaria elimination and the E-2025 Global Forum; 5) an update on the RTS,S/AS01 Malaria Vaccine Implementation Programme and WHO evidence review for the R21/Matrix-M vaccine; 6) an update on the work areas of the Strategic Information for Response Unit; 7) a report from the technical consultation on the effectiveness of rectal artesunate (RAS) and field implementation manual; 8) a report from the technical consultation on community-based delivery of intermittent preventive treatment of malaria in pregnancy (IPTp); 9) an update on the WHO/TDR field implementation manual for seasonal malaria chemoprevention (SMC); 10) an update on the Anopheles stephensi regional strategy; 11) an update on histidine-rich protein 2 (HRP2) gene deletions and global response plan; and 12) an update on antimalarial drug resistance in Africa.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240063307
Category : Medical
Languages : en
Pages : 25
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Book Description
Author: World Health Organization
Publisher: World Health Organization
ISBN: 924008617X
Category : Medical
Languages : en
Pages : 356
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Book Description
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240090142
Category : Medical
Languages : en
Pages : 84
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Book Description
As WHO's technical department for malaria, the Global Malaria Programme has an important role to play in leading the global response against this disease. Through its direct actions and network, it has the potential to shape the malaria ecosystem and achieve impact at country level. With this in mind, the Global Malaria Programme has developed an operational strategy outlining its priorities for the period 2024‒2030 and the 4 strategic levers to control and eliminate malaria that are decisively within the Programme’s mandate: norms and standards, new tools and innovation, strategic information for impact, and leadership. The strategy describes how the Global Malaria Programme will also transform by collaborating more effectively with other programmes, regional and country offices and partners, guided by lessons learned from WHO’s Thirteenth General Programme of Work (GPW13) and the GPW14 priorities.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240089640
Category : Medical
Languages : en
Pages : 22
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Book Description
On 30 October–1 November 2023, the WHO Malaria Policy Advisory Group (MPAG) convened to review updates and progress, and to provide guidance on thematic areas of work by the Global Malaria Programme. The meeting focused on the following topics: the Global Malaria Programme operational strategy 2024–2030; malaria vaccines R21/Matrix-M and RTS,S/AS01, the Malaria Vaccine Implementation Programme (MVIP) and status of malaria vaccine roll-out; guiding principles for prioritizing malaria interventions in resource-constrained settings to achieve maximum impact; progress and challenges on subnational tailoring of interventions; comparative effectiveness in the context of the arrival of new vector control products; the “High burden to high impact” (HBHI) approach; the WHO guidelines for malaria; antimalarial drug resistance in Africa; and the Mekong Malaria Elimination programme.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309165938
Category : Medical
Languages : en
Pages : 384
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Book Description
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
