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Author: Armin de Meijere
Publisher: Springer Science & Business Media
ISBN: 9400909292
Category : Science
Languages : en
Pages : 520
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Book Description
The topic ·Stress and Strain· of this conference was ideally constrasted by the remoteness and quiet atmosphere of the meeting place Hotel Seehof In Ratzeburg, a small medieval town situated on a peninsula in lake "Kuchensee· east of Hamburg In northern Germany. With the participation of 53 leading experts from all over the world, the workshop covered the widest possible range from the advancement of bonding theory, new mechanistic insights into chemical transformations and physical properties of highly strained compounds to their use as building blocks In organic synthesis and even as probes Into the detection of enzyme mechanisms. Because of their specific reactivities small ring units can uniquely play their role in the construction of composite functionalities. Such functionalities can increase the elegance In natural and non-natural products syntheses, since they help to develop more convergent synthetic routes and Improve the necessary chemo-, regio-and stereo-selectivity. This book presents all of the 20 Invited lectures and is complemented with short versions of 12 contributed papers and 13 poster presentations. I am convinced that it will stimulate further rapid development of this field of organic chemistry, which recently has seen extensions into the bioorganic area as well as towards new materials. In fact, several ·supra-natural" -at first sight exotic -compounds are already available In useful quantities and are being exploited to create vastly new molecular devices, i. e. compounds with unprecedented molecular functions and polymers with unconventional properties.
Author: Armin de Meijere
Publisher: Springer Science & Business Media
ISBN: 9400909292
Category : Science
Languages : en
Pages : 520
Get Book Here
Book Description
The topic ·Stress and Strain· of this conference was ideally constrasted by the remoteness and quiet atmosphere of the meeting place Hotel Seehof In Ratzeburg, a small medieval town situated on a peninsula in lake "Kuchensee· east of Hamburg In northern Germany. With the participation of 53 leading experts from all over the world, the workshop covered the widest possible range from the advancement of bonding theory, new mechanistic insights into chemical transformations and physical properties of highly strained compounds to their use as building blocks In organic synthesis and even as probes Into the detection of enzyme mechanisms. Because of their specific reactivities small ring units can uniquely play their role in the construction of composite functionalities. Such functionalities can increase the elegance In natural and non-natural products syntheses, since they help to develop more convergent synthetic routes and Improve the necessary chemo-, regio-and stereo-selectivity. This book presents all of the 20 Invited lectures and is complemented with short versions of 12 contributed papers and 13 poster presentations. I am convinced that it will stimulate further rapid development of this field of organic chemistry, which recently has seen extensions into the bioorganic area as well as towards new materials. In fact, several ·supra-natural" -at first sight exotic -compounds are already available In useful quantities and are being exploited to create vastly new molecular devices, i. e. compounds with unprecedented molecular functions and polymers with unconventional properties.
Author: Felix A. Carroll
Publisher: John Wiley & Sons
ISBN: 1119808642
Category : Science
Languages : en
Pages : 869
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Book Description
PERSPECTIVES ON STRUCTURE AND MECHANISM IN ORGANIC CHEMISTRY “Beyond the basics” physical organic chemistry textbook, written for advanced undergraduates and beginning graduate students Based on the author’s first-hand classroom experience, Perspectives on Structure and Mechanism in Organic Chemistry uses complementary conceptual models to give new perspectives on the structures and reactions of organic compounds, with the overarching goal of helping students think beyond the simple models of introductory organic chemistry courses. Through this approach, the text better prepares readers to develop new ideas in the future. In the 3rd Edition, the author thoroughly updates the topics covered and reorders the contents to introduce computational chemistry earlier and to provide a more natural flow of topics, proceeding from substitution, to elimination, to addition. About 20% of the 438 problems have been either replaced or updated, with answers available in the companion solutions manual. To remind students of the human aspect of science, the text uses the names of investigators throughout the text and references material to original (or accessible secondary or tertiary) literature as a guide for students interested in further reading. Sample topics covered in Perspectives on Structure and Mechanism in Organic Chemistry include: Fundamental concepts of organic chemistry, covering atoms and molecules, heats of formation and reaction, bonding models, and double bonds Density functional theory, quantum theory of atoms in molecules, Marcus Theory, and molecular simulations Asymmetric induction in nucleophilic additions to carbonyl compounds and dynamic effects on reaction pathways Reactive intermediates, covering reaction coordinate diagrams, radicals, carbenes, carbocations, and carbanions Methods of studying organic reactions, including applications of kinetics in studying reaction mechanisms and Arrhenius theory and transition state theory A comprehensive yet accessible reference on the subject, Perspectives on Structure and Mechanism in Organic Chemistry is an excellent learning resource for students of organic chemistry, medicine, and biochemistry. The text is ideal as a primary text for courses entitled Advanced Organic Chemistry at the upper undergraduate and graduate levels.
Author: István Hargittai
Publisher:
ISBN: 9783527283330
Category : Chemistry, Organic
Languages : en
Pages : 128
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Book Description
Author: Veejendra K. Yadav
Publisher: Springer
ISBN: 9811011397
Category : Science
Languages : en
Pages : 216
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Book Description
The steric and stereoelectronic effects control the rate and stereochemical outcome of reactions. Hence, a decent understanding of the related concepts is essential for successful synthetic planning. The book attempts to address several important issues related to these concepts in a simplified manner, and is intended for graduate students. It lays stress on the important aspects of steric and stereoelectronic effects and their control on the conformational profile and reactivity features. The book covers the geometrical requirements for reactions at saturated and unsaturated carbons in both cyclic and acyclic systems, and the resultant stereochemical features. The aspect of geometrical flexibility is also covered with a few examples involving intramolecular reactions. It deals with the facial selectivity of nucleophilic additions to acyclic and cyclic carbonyl compounds, and explains how the steric and stereoelectronic effects control the same. The work comments on allylic strains and their stereochemical control on different reactions with the related conformational control. It is a must read to understand the control elements, the prominent among these elements are spiro-conjugation, periselectivity, torquoselectivity, a-effect, Hammett’s substituent constants, Hammond postulate, and Curtin-Hammett principle.
Author: Zvi Rappoport
Publisher: John Wiley & Sons
ISBN: 047086401X
Category : Science
Languages : en
Pages : 1266
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Book Description
The Chemistry of Cyclobutanes provides an in depth and comprehensive review of cyclobutanes and includes chapters on the theoretical and computational foundations; on analytical and spectroscopical aspects with dedicated chapters on Mass Spectrometry, NMR and IR/UV. There are also extensive application examples enabling the reader to collect both a theoretical and practical understanding. The Chemistry of Functional Groups Series was originally founded by Saul Patai (1918-1998) and in the 39 years of publishing has produced more than 100 volumes, providing outstanding reviews on all aspects of functional groups including analytical, physical and synthetic and applied chemistry. Saul Patai has been helped by outstanding editors, especially Zvi Rappoport who has now taken responsibility for the series to continue the tradition of producing high quality reviews with editors such as Y. Apeloig, I. Marek and J. Liebman.
Author: Robert A. Moss
Publisher: John Wiley & Sons
ISBN: 9780471233244
Category : Science
Languages : en
Pages : 1088
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Book Description
Reactive Intermediate Chemistry presents a detailed and timely examination of key intermediates central to the mechanisms of numerous organic chemical transformations. Spectroscopy, kinetics, and computational studies are integrated in chapters dealing with the chemistry of carbocations, carbanions, radicals, radical ions, carbenes, nitrenes, arynes, nitrenium ions, diradicals, etc. Nanosecond, picosecond, and femtosecond kinetic realms are explored, and applications of current dynamics and electronic structure calculations are examined. Reactive Intermediate Chemistry provides a deeper understanding of contemporary physical organic chemistry, and will assist chemists in the design of new reactions for the efficient synthesis of pharmaceuticals, fine chemicals, and agricultural products. Among its features, this authoritative volume is: Edited and authored by world-renowned leaders in physical organic chemistry. Ideal for use as a primary or supplemental graduate textbook for courses in mechanistic organic chemistry or physical chemistry. Enhanced by supplemental reading lists and summary overviews in each chapter.
Author: Sigrid D. Peyerimhoff
Publisher: John Wiley & Sons
ISBN: 9783527277322
Category : Science
Languages : en
Pages : 380
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Book Description
Experimentalists and theoreticians from chemistry and physics present various interactions in molecules using methods of chemical synthesis, structural analysis, spectroscopy and quantum chemical computations. This work constitutes an important basis in the investigation of increasingly more complex systems such as the study of the action of drugs in pharmaceutical research. The book gives an excellent survey for the specialist and also a welcome introduction for the advanced graduate student and the researcher in neighboring fields.
Author: Francis A. Carey
Publisher: Springer Science & Business Media
ISBN: 0306468565
Category : Science
Languages : en
Pages : 830
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Book Description
Since its original appearance in 1977, Advanced Organic Chemistry has found wide use as a text providing broad coverage of the structure, reactivity and synthesis of organic compounds. The Fourth Edition provides updated material but continues the essential elements of the previous edition. The material in Part A is organized on the basis of fundamental structural topics such as structure, stereochemistry, conformation and aromaticity and basic mechanistic types, including nucleophilic substitution, addition reactions, carbonyl chemistry, aromatic substitution and free radical reactions. The material in Part B is organized on the basis of reaction type with emphasis on reactions of importance in laboratory synthesis. As in the earlier editions, the text contains extensive references to both the primary and review literature and provides examples of data and reactions that illustrate and document the generalizations. While the text assumes completion of an introductory course in organic chemistry, it reviews the fundamental concepts for each topic that is discussed. The Fourth Edition updates certain topics that have advanced rapidly in the decade since the Third Edition was published, including computational chemistry, structural manifestations of aromaticity, enantioselective reactions and lanthanide catalysis. The two parts stand alone, although there is considerable cross-referencing. Part A emphasizes quantitative and qualitative description of structural effects on reactivity and mechanism. Part B emphasizes the most general and useful synthetic reactions. The focus is on the core of organic chemistry, but the information provided forms the foundation for future study and research in medicinal and pharmaceutical chemistry, biological chemistry and physical properties of organic compounds. The New Revised 5th Edition will be available shortly. For details, click on the link in the right-hand column.
Author: Armin de Meijere
Publisher: Springer
ISBN: 3540482555
Category : Science
Languages : en
Pages : 237
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Book Description
This current and five previous volumes (Volumes 133, 135, 144, 155, 178) convincingly demonstrate the vast applications of small rings in modern Organic Synthesis. Such applications range from total syntheses of cyclopropyl-group-containing natural products and non-natural biologically active compounds or compounds with other important properties (e.g. liquid crystalline) via syntheses of cyclopropyl analogues of natural and non-natural physiologically active compounds, e.g. peptidomimetics, to the use of cyclopropyl groups as reactive subunits in so-called composite functional groups. This current volume covers a survey of the wide range of biological activities of cyclopropyl-containing compounds, up-to-date comprehensive reviews on the multiple applicabilities of two multifunctional small ring building blocks - methyl-2-chloro-2-cyclopropylidene acetate and bicyclopropylidene - in Organic Synthesis as well as a striking new approach to cyclopentenones from easily accessible 1-ethynylcyclopropanols, which is rather general and favorably complements other cyclopentenone syntheses.
Author: Michael B. Smith
Publisher: John Wiley & Sons
ISBN: 0470084944
Category : Science
Languages : en
Pages : 2379
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Book Description
The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
