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Author: M.Elizabeth Halloran
Publisher: Springer Science & Business Media
ISBN: 9780387989242
Category : Medical
Languages : en
Pages : 300
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Book Description
This IMA Volume in Mathematics and its Applications STATISTICAL MODELS IN EPIDEMIOLOGY, THE ENVIRONMENT,AND CLINICAL TRIALS is a combined proceedings on "Design and Analysis of Clinical Trials" and "Statistics and Epidemiology: Environment and Health. " This volume is the third series based on the proceedings of a very successful 1997 IMA Summer Program on "Statistics in the Health Sciences. " I would like to thank the organizers: M. Elizabeth Halloran of Emory University (Biostatistics) and Donald A. Berry of Duke University (Insti tute of Statistics and Decision Sciences and Cancer Center Biostatistics) for their excellent work as organizers of the meeting and for editing the proceedings. I am grateful to Seymour Geisser of University of Minnesota (Statistics), Patricia Grambsch, University of Minnesota (Biostatistics); Joel Greenhouse, Carnegie Mellon University (Statistics); Nicholas Lange, Harvard Medical School (Brain Imaging Center, McLean Hospital); Barry Margolin, University of North Carolina-Chapel Hill (Biostatistics); Sandy Weisberg, University of Minnesota (Statistics); Scott Zeger, Johns Hop kins University (Biostatistics); and Marvin Zelen, Harvard School of Public Health (Biostatistics) for organizing the six weeks summer program. I also take this opportunity to thank the National Science Foundation (NSF) and the Army Research Office (ARO), whose financial support made the workshop possible. Willard Miller, Jr.
Author: M.Elizabeth Halloran
Publisher: Springer Science & Business Media
ISBN: 9780387989242
Category : Medical
Languages : en
Pages : 300
Get Book Here
Book Description
This IMA Volume in Mathematics and its Applications STATISTICAL MODELS IN EPIDEMIOLOGY, THE ENVIRONMENT,AND CLINICAL TRIALS is a combined proceedings on "Design and Analysis of Clinical Trials" and "Statistics and Epidemiology: Environment and Health. " This volume is the third series based on the proceedings of a very successful 1997 IMA Summer Program on "Statistics in the Health Sciences. " I would like to thank the organizers: M. Elizabeth Halloran of Emory University (Biostatistics) and Donald A. Berry of Duke University (Insti tute of Statistics and Decision Sciences and Cancer Center Biostatistics) for their excellent work as organizers of the meeting and for editing the proceedings. I am grateful to Seymour Geisser of University of Minnesota (Statistics), Patricia Grambsch, University of Minnesota (Biostatistics); Joel Greenhouse, Carnegie Mellon University (Statistics); Nicholas Lange, Harvard Medical School (Brain Imaging Center, McLean Hospital); Barry Margolin, University of North Carolina-Chapel Hill (Biostatistics); Sandy Weisberg, University of Minnesota (Statistics); Scott Zeger, Johns Hop kins University (Biostatistics); and Marvin Zelen, Harvard School of Public Health (Biostatistics) for organizing the six weeks summer program. I also take this opportunity to thank the National Science Foundation (NSF) and the Army Research Office (ARO), whose financial support made the workshop possible. Willard Miller, Jr.
Author: David Clayton
Publisher: Oxford University Press, USA
ISBN: 0199671184
Category : Mathematics
Languages : en
Pages : 376
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Book Description
This self-contained account of the statistical basis of epidemiology has been written for those with a basic training in biology. It is specifically intended for students enrolled for a masters degree in epidemiology, clinical epidemiology, or biostatistics.
Author: M. Elizabeth Halloran
Publisher:
ISBN: 9781461212850
Category :
Languages : en
Pages : 296
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Book Description
Author: Duncan C. Thomas
Publisher: Oxford University Press, USA
ISBN: 0191552682
Category : Medical
Languages : en
Pages : 450
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Book Description
A systematic treatment of the statistical challenges that arise in environmental health studies and the use epidemiologic data in formulating public policy, at a level suitable for graduate students and epidemiologic researchers.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309171148
Category : Medical
Languages : en
Pages : 221
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Book Description
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author: Charles DiMaggio
Publisher: Springer Science & Business Media
ISBN: 1461448549
Category : Mathematics
Languages : en
Pages : 266
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Book Description
This comprehensive text covers the use of SAS for epidemiology and public health research. Developed with students in mind and from their feedback, the text addresses this material in a straightforward manner with a multitude of examples. It is directly applicable to students and researchers in the fields of public health, biostatistics and epidemiology. Through a “hands on” approach to the use of SAS for a broad number of epidemiologic analyses, readers learn techniques for data entry and cleaning, categorical analysis, ANOVA, and linear regression and much more. Exercises utilizing real-world data sets are featured throughout the book. SAS screen shots demonstrate the steps for successful programming. SAS (Statistical Analysis System) is an integrated system of software products provided by the SAS institute, which is headquartered in California. It provides programmers and statisticians the ability to engage in many sophisticated statistical analyses and data retrieval and mining exercises. SAS is widely used in the fields of epidemiology and public health research, predominately due to its ability to reliably analyze very large administrative data sets, as well as more commonly encountered clinical trial and observational research data.
Author: Agency for Health Care Research and Quality (U.S.)
Publisher: Government Printing Office
ISBN: 1587634236
Category : Medical
Languages : en
Pages : 236
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Book Description
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Author: Peter D. Congdon
Publisher: CRC Press
ISBN: 0429532903
Category : Mathematics
Languages : en
Pages : 487
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Book Description
An intermediate-level treatment of Bayesian hierarchical models and their applications, this book demonstrates the advantages of a Bayesian approach to data sets involving inferences for collections of related units or variables, and in methods where parameters can be treated as random collections. Through illustrative data analysis and attention to statistical computing, this book facilitates practical implementation of Bayesian hierarchical methods. The new edition is a revision of the book Applied Bayesian Hierarchical Methods. It maintains a focus on applied modelling and data analysis, but now using entirely R-based Bayesian computing options. It has been updated with a new chapter on regression for causal effects, and one on computing options and strategies. This latter chapter is particularly important, due to recent advances in Bayesian computing and estimation, including the development of rjags and rstan. It also features updates throughout with new examples. The examples exploit and illustrate the broader advantages of the R computing environment, while allowing readers to explore alternative likelihood assumptions, regression structures, and assumptions on prior densities. Features: Provides a comprehensive and accessible overview of applied Bayesian hierarchical modelling Includes many real data examples to illustrate different modelling topics R code (based on rjags, jagsUI, R2OpenBUGS, and rstan) is integrated into the book, emphasizing implementation Software options and coding principles are introduced in new chapter on computing Programs and data sets available on the book’s website
Author: Andrew G. Dean
Publisher: Createspace Independent Publishing Platform
ISBN: 9781449538910
Category : Computer programs
Languages : en
Pages : 0
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Book Description
Epi Info is a free computer program from the Centers for Disease Control and Prevention(CDC), downloaded 2 million times since 1998, and referred to in over 1 million web pages. It allows anyone with a computer to design a questionnaire, enter data, and do tabulation and statitistical analysis. This book tells how to use Epi Info for rapid surveys and research studies and for constructing electronic medical records, public health surveillance systems. graphs, and maps. Sample programs can be downloaded from the web.
Author: Andrew Gelman
Publisher: John Wiley & Sons
ISBN: 9780470090435
Category : Mathematics
Languages : en
Pages : 448
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Book Description
This book brings together a collection of articles on statistical methods relating to missing data analysis, including multiple imputation, propensity scores, instrumental variables, and Bayesian inference. Covering new research topics and real-world examples which do not feature in many standard texts. The book is dedicated to Professor Don Rubin (Harvard). Don Rubin has made fundamental contributions to the study of missing data. Key features of the book include: Comprehensive coverage of an imporant area for both research and applications. Adopts a pragmatic approach to describing a wide range of intermediate and advanced statistical techniques. Covers key topics such as multiple imputation, propensity scores, instrumental variables and Bayesian inference. Includes a number of applications from the social and health sciences. Edited and authored by highly respected researchers in the area.
