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Author: William D. Dupont
Publisher: Cambridge University Press
ISBN: 0521849527
Category : Medical
Languages : en
Pages : 543
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Book Description
A second edition of the easy-to-use standard text guiding biomedical researchers in the use of advanced statistical methods.
Author: William D. Dupont
Publisher: Cambridge University Press
ISBN: 0521849527
Category : Medical
Languages : en
Pages : 543
Get Book Here
Book Description
A second edition of the easy-to-use standard text guiding biomedical researchers in the use of advanced statistical methods.
Author: Yichuan Zhao
Publisher: Springer Nature
ISBN: 3030334163
Category : Medical
Languages : en
Pages : 495
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Book Description
This edited collection discusses the emerging topics in statistical modeling for biomedical research. Leading experts in the frontiers of biostatistics and biomedical research discuss the statistical procedures, useful methods, and their novel applications in biostatistics research. Interdisciplinary in scope, the volume as a whole reflects the latest advances in statistical modeling in biomedical research, identifies impactful new directions, and seeks to drive the field forward. It also fosters the interaction of scholars in the arena, offering great opportunities to stimulate further collaborations. This book will appeal to industry data scientists and statisticians, researchers, and graduate students in biostatistics and biomedical science. It covers topics in: Next generation sequence data analysis Deep learning, precision medicine, and their applications Large scale data analysis and its applications Biomedical research and modeling Survival analysis with complex data structure and its applications.
Author: William D. Dupont
Publisher: Cambridge University Press
ISBN: 1139643819
Category : Medical
Languages : en
Pages : 543
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Book Description
The second edition of this standard text guides biomedical researchers in the selection and use of advanced statistical methods and the presentation of results to clinical colleagues. It assumes no knowledge of mathematics beyond high school level and is accessible to anyone with an introductory background in statistics. The Stata statistical software package is again used to perform the analyses, this time employing the much improved version 10 with its intuitive point and click as well as character-based commands. Topics covered include linear, logistic and Poisson regression, survival analysis, fixed-effects analysis of variance, and repeated-measure analysis of variance. Restricted cubic splines are used to model non-linear relationships. Each method is introduced in its simplest form and then extended to cover more complex situations. An appendix will help the reader select the most appropriate statistical methods for their data. The text makes extensive use of real data sets available at http://biostat.mc.vanderbilt.edu/dupontwd/wddtext/.
Author: J. Philip Miller
Publisher: Elsevier
ISBN: 0444537384
Category : Mathematics
Languages : en
Pages : 363
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Book Description
Essential Statistical Methods for Medical Statistics presents only key contributions which have been selected from the volume in the Handbook of Statistics: Medical Statistics, Volume 27 (2009). While the use of statistics in these fields has a long and rich history, the explosive growth of science in general, and of clinical and epidemiological sciences in particular, has led to the development of new methods and innovative adaptations of standard methods. This volume is appropriately focused for individuals working in these fields. Contributors are internationally renowned experts in their respective areas. - Contributors are internationally renowned experts in their respective areas - Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research - Methods for assessing Biomarkers, analysis of competing risks - Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs - Structural equations modelling and longitudinal data analysis
Author:
Publisher: Elsevier
ISBN: 0080554210
Category : Mathematics
Languages : en
Pages : 871
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Book Description
This volume, representing a compilation of authoritative reviews on a multitude of uses of statistics in epidemiology and medical statistics written by internationally renowned experts, is addressed to statisticians working in biomedical and epidemiological fields who use statistical and quantitative methods in their work. While the use of statistics in these fields has a long and rich history, explosive growth of science in general and clinical and epidemiological sciences in particular have gone through a see of change, spawning the development of new methods and innovative adaptations of standard methods. Since the literature is highly scattered, the Editors have undertaken this humble exercise to document a representative collection of topics of broad interest to diverse users. The volume spans a cross section of standard topics oriented toward users in the current evolving field, as well as special topics in much need which have more recent origins. This volume was prepared especially keeping the applied statisticians in mind, emphasizing applications-oriented methods and techniques, including references to appropriate software when relevant.· Contributors are internationally renowned experts in their respective areas· Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research· Methods for assessing Biomarkers, analysis of competing risks· Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs· Structural equations modelling and longitudinal data analysis
Author: Richard Shiavi
Publisher: Elsevier
ISBN: 0080467687
Category : Technology & Engineering
Languages : en
Pages : 424
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Book Description
Introduction to Applied Statistical Signal Analysis, Third Edition, is designed for the experienced individual with a basic background in mathematics, science, and computer. With this predisposed knowledge, the reader will coast through the practical introduction and move on to signal analysis techniques, commonly used in a broad range of engineering areas such as biomedical engineering, communications, geophysics, and speech. Topics presented include mathematical bases, requirements for estimation, and detailed quantitative examples for implementing techniques for classical signal analysis. This book includes over one hundred worked problems and real world applications. Many of the examples and exercises use measured signals, most of which are from the biomedical domain. The presentation style is designed for the upper level undergraduate or graduate student who needs a theoretical introduction to the basic principles of statistical modeling and the knowledge to implement them practically. Includes over one hundred worked problems and real world applications. Many of the examples and exercises in the book use measured signals, many from the biomedical domain.
Author: Frank E. Harrell
Publisher: Springer Science & Business Media
ISBN: 147573462X
Category : Mathematics
Languages : en
Pages : 583
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Book Description
Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309171148
Category : Medical
Languages : en
Pages : 221
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Book Description
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author: Ewout W. Steyerberg
Publisher: Springer
ISBN: 3030163997
Category : Medical
Languages : en
Pages : 574
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Book Description
The second edition of this volume provides insight and practical illustrations on how modern statistical concepts and regression methods can be applied in medical prediction problems, including diagnostic and prognostic outcomes. Many advances have been made in statistical approaches towards outcome prediction, but a sensible strategy is needed for model development, validation, and updating, such that prediction models can better support medical practice. There is an increasing need for personalized evidence-based medicine that uses an individualized approach to medical decision-making. In this Big Data era, there is expanded access to large volumes of routinely collected data and an increased number of applications for prediction models, such as targeted early detection of disease and individualized approaches to diagnostic testing and treatment. Clinical Prediction Models presents a practical checklist that needs to be considered for development of a valid prediction model. Steps include preliminary considerations such as dealing with missing values; coding of predictors; selection of main effects and interactions for a multivariable model; estimation of model parameters with shrinkage methods and incorporation of external data; evaluation of performance and usefulness; internal validation; and presentation formatting. The text also addresses common issues that make prediction models suboptimal, such as small sample sizes, exaggerated claims, and poor generalizability. The text is primarily intended for clinical epidemiologists and biostatisticians. Including many case studies and publicly available R code and data sets, the book is also appropriate as a textbook for a graduate course on predictive modeling in diagnosis and prognosis. While practical in nature, the book also provides a philosophical perspective on data analysis in medicine that goes beyond predictive modeling. Updates to this new and expanded edition include: • A discussion of Big Data and its implications for the design of prediction models • Machine learning issues • More simulations with missing ‘y’ values • Extended discussion on between-cohort heterogeneity • Description of ShinyApp • Updated LASSO illustration • New case studies
Author: Sy-Miin Chow
Publisher: Routledge
ISBN: 1135262586
Category : Psychology
Languages : en
Pages : 442
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Book Description
This interdisciplinary volume features contributions from researchers in the fields of psychology, neuroscience, statistics, computer science, and physics. State-of-the-art techniques and applications used to analyze data obtained from studies in cognition, emotion, and electrophysiology are reviewed along with techniques for modeling in real time and for examining lifespan cognitive changes, for conceptualizing change using item response, nonparametric and hierarchical models, and control theory-inspired techniques for deriving diagnoses in medical and psychotherapeutic settings. The syntax for running the analyses presented in the book is provided on the Psychology Press site. Most of the programs are written in R while others are for Matlab, SAS, Win-BUGS, and DyFA. Readers will appreciate a review of the latest methodological techniques developed in the last few years. Highlights include an examination of: Statistical and mathematical modeling techniques for the analysis of brain imaging such as EEGs, fMRIs, and other neuroscience data Dynamic modeling techniques for intensive repeated measurement data Panel modeling techniques for fewer time points data State-space modeling techniques for psychological data Techniques used to analyze reaction time data. Each chapter features an introductory overview of the techniques needed to understand the chapter, a summary, and numerous examples. Each self-contained chapter can be read on its own and in any order. Divided into three major sections, the book examines techniques for examining within-person derivations in change patterns, intra-individual change, and inter-individual differences in change and interpersonal dynamics. Intended for advanced students and researchers, this book will appeal to those interested in applying state-of-the-art dynamic modeling techniques to the the study of neurological, developmental, cognitive, and social/personality psychology, as well as neuroscience, computer science, and engineering.
