Splines and Compartment Models PDF Download
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Author: Karl-Ernst Biebler
Publisher: World Scientific
ISBN: 9814522236
Category : Mathematics
Languages : en
Pages : 349
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Book Description
This book presents methods of mathematical modeling from two points of view. Splines provide a general approach while compartment models serve as examples for context related to modeling. The preconditions and characteristics of the developed mathematical models as well as the conditions surrounding data collection and model fit are taken into account. The substantial statements of this book are mathematically proven. The results are ready for application with examples and related program codes given. In this book, splines are algebraically developed such that the reader or user can easily understand and vary the numerical construction of the different kinds of spline functions. The classical compartment models of the pharmacokinetics are systematically analyzed and connected with lifetime distributions. As such, parameter estimation and model fit can be treated statistically with a varied minimum chi-square method. This method is applicable for single kinetics and also allows the calculation of average kinetics.
Author: Karl-Ernst Biebler
Publisher: World Scientific
ISBN: 9814522236
Category : Mathematics
Languages : en
Pages : 349
Get Book Here
Book Description
This book presents methods of mathematical modeling from two points of view. Splines provide a general approach while compartment models serve as examples for context related to modeling. The preconditions and characteristics of the developed mathematical models as well as the conditions surrounding data collection and model fit are taken into account. The substantial statements of this book are mathematically proven. The results are ready for application with examples and related program codes given. In this book, splines are algebraically developed such that the reader or user can easily understand and vary the numerical construction of the different kinds of spline functions. The classical compartment models of the pharmacokinetics are systematically analyzed and connected with lifetime distributions. As such, parameter estimation and model fit can be treated statistically with a varied minimum chi-square method. This method is applicable for single kinetics and also allows the calculation of average kinetics.
Author: Larry L. Schumaker
Publisher: SIAM
ISBN: 1611973902
Category : Science
Languages : en
Pages : 420
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Book Description
This book describes in detail the key algorithms needed for computing with spline functions and illustrates their use in solving several basic problems in numerical analysis, including function approximation, numerical quadrature, data fitting, and the numerical solution of PDE's. The focus is on computational methods for bivariate splines on triangulations in the plane and on the sphere, although both univariate and tensor-product splines are also discussed. The book contains numerous examples and figures to illustrate the methods and their performance. All of the algorithms in the book have been coded in a separate MATLAB package available for license. The package can be used to run all of the examples in the book and also provides readers with the essential tools needed to create software for their own applications. In addition to the included bibliography, a list of over 100 pages of additional references can be found on the book's website.
Author: Klaus Hollig
Publisher: SIAM
ISBN: 1611972949
Category : Mathematics
Languages : en
Pages : 228
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Book Description
B-splines are fundamental to approximation and data fitting, geometric modeling, automated manufacturing, computer graphics, and numerical simulation. With an emphasis on key results and methods that are most widely used in practice, this textbook provides a unified introduction to the basic components of B-spline theory: approximation methods (mathematics), modeling techniques (engineering), and geometric algorithms (computer science). A supplemental Web site will provide a collection of problems, some with solutions, slides for use in lectures, and programs with demos.
Author: Grace Wahba
Publisher: SIAM
ISBN: 0898712440
Category : Mathematics
Languages : en
Pages : 174
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Book Description
This book serves well as an introduction into the more theoretical aspects of the use of spline models. It develops a theory and practice for the estimation of functions from noisy data on functionals. The simplest example is the estimation of a smooth curve, given noisy observations on a finite number of its values. Convergence properties, data based smoothing parameter selection, confidence intervals, and numerical methods are established which are appropriate to a number of problems within this framework. Methods for including side conditions and other prior information in solving ill posed inverse problems are provided. Data which involves samples of random variables with Gaussian, Poisson, binomial, and other distributions are treated in a unified optimization context. Experimental design questions, i.e., which functionals should be observed, are studied in a general context. Extensions to distributed parameter system identification problems are made by considering implicitly defined functionals.
Author: Hans Hagen
Publisher: Springer Science & Business Media
ISBN: 3642764045
Category : Computers
Languages : en
Pages : 291
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Book Description
This book is based on lectures presented at an international workshop on geometric modeling held at Hewlett Packard GmbH in Boblingen, FRG, in June 1990. International experts from academia and industry were selected to speak on the most interesting topics in geometric modeling. The resulting papers, published in this volume, give a state-of-the-art survey of the relevant problems and issues. The following topics are discussed: - Methods for constructing surfaces on surfaces: four different solutions to the multidimen sional problem of constructing an interpolant from surface data are provided. - Surfaces in solid modeling: current results on the implementation of free-fonn solids in three well established solid models are reviewed. - Box splines and applications: an introduction to box spline methods for the representation of surfaces is given. Basic properties of box splines are derived, and refinement and evaluation methods for box splines are presented in detail. Shape preserving properties, the construction of non-rectangular box spline surfaces, applications to surface modeling, and imbedding problems, are discussed. - Advanced computer graphics techniques for volume visualization: the steps to be executed in the visualization process of volume data are described and tools are discussed that assist in handling this data. - Rational B-splines: an introduction to the representation of curves and surfaces using rational B-splines is given, together with a critical evaluation of their potential for industrial application.
Author:
Publisher: Newnes
ISBN: 0444536337
Category : Science
Languages : en
Pages : 4052
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Book Description
Comprehensive Biomedical Physics, Ten Volume Set is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color
Author: ELAINE AUTOR COHEN
Publisher: A K Peters Ltd
ISBN: 9781568811376
Category : Computers
Languages : en
Pages : 616
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Book Description
Written by researchers who have helped found and shape the field, this book is a definitive introduction to geometric modeling. The authors present all of the necessary techniques for curve and surface representations in computer-aided modeling with a focus on how the techniques are used in design. They achieve a balance between mathematical rigor and broad applicability. Appropriate for readers with a moderate degree of mathematical maturity, this book is suitable as an undergraduate or graduate text, or particularly as a resource for self-study.
Author: Nicole Lehmann
Publisher: Logos Verlag Berlin GmbH
ISBN: 3832536027
Category : Computers
Languages : en
Pages : 126
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Book Description
The present thesis introduces a new approach for the generation of CK-approximants of functions defined on closed submanifolds for arbitrary k ∈ N. In case a function on a surface resembles the three coordinates of a topologically equivalent surface in R3, we even obtain Ck-approximants of closed surfaces of arbitrary topology. The key idea of our method is a constant extension of the target function into the submanifold's ambient space. In case the reference submanifolds are embedded and Ck, the usage of standard tensor product B-splines for the approximation of the extended function is straightforward. We obtain a Ck-approximation of the target function by restricting the approximant to the reference submanifold. We illustrate our method by an easy example in R2 and verify its practicality by application-oriented examples in R3. The first treats the approximation of the geoid, an important reference magnitude within geodesy and geophysics. The second and third example treat the approximation of geometric models. The usage of B-splines not only guarantees full approximation power but also allows a canonical access to adaptive refinement strategies. We elaborate on two hierarchical techniques and successfully apply them to the introduced examples. Concerning the modeling of surfaces by the new approach, we derive numerically robust formulas for the determination of normal vectors and curvature information of a target surface which only need the spline approximant as well as the normal vectors and curvature information of the reference surface.
Author: David H. Anderson
Publisher: Springer Science & Business Media
ISBN: 3642518613
Category : Science
Languages : en
Pages : 312
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Book Description
This monograph is concerned with mathematical aspects of compartmental an alysis. In particular, linear models are closely analyzed since they are fully justifiable as an investigative tool in tracer experiments. The objective of the monograph is to bring the reader up to date on some of the current mathematical prob lems of interest in compartmental analysis. This is accomplished by reviewing mathematical developments in the literature, especially over the last 10-15 years, and by presenting some new thoughts and directions for future mathematical research. These notes started as a series of lectures that I gave while visiting with the Division of Applied ~1athematics, Brown University, 1979, and have developed in to this collection of articles aimed at the reader with a beginning graduate level background in mathematics. The text can be used as a self-paced reading course. With this in mind, exercises have been appropriately placed throughout the notes. As an aid in reading the material, the e~d of a proof is indicated by ~. Sub section titles are utilized to make it easier for the reader to skim over detailed material on a first reading and make the entire manuscript somewhat more accessible, especially to nonmathematicians in the biosciences. The preparation of this monograph has been a long task that would not have been completed without the influence of a number of individuals. I am especially indebted to H. T. Banks, J. W. Drane, J. Eisenfe1d, J. A. Jacquez, D. J.
Author: Jauch, Jens
Publisher: KIT Scientific Publishing
ISBN: 3731513323
Category :
Languages : en
Pages : 264
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Book Description
This work describes a method for weighted least squares approximation of an unbounded number of data points using a B-spline function. The method can shift the bounded B-spline function definition range during run-time. The approximation method is used for optimizing velocity trajectories for an electric vehicle with respect to travel time, comfort and energy consumption. The trajectory optimization method is extended to a driver assistance system for automated vehicle longitudinal control.
