Sphingolipids: Basic Science and Drug Development PDF Download
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Author: Erich Gulbins
Publisher: Springer Science & Business Media
ISBN: 3709113687
Category : Medical
Languages : en
Pages : 264
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Book Description
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
Author: Erich Gulbins
Publisher: Springer Science & Business Media
ISBN: 3709113687
Category : Medical
Languages : en
Pages : 264
Get Book Here
Book Description
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
Author: Erich Gulbins
Publisher: Springer Science & Business Media
ISBN: 3709115116
Category : Medical
Languages : en
Pages : 474
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Book Description
Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.
Author: Xian-Cheng Jiang
Publisher: Springer Nature
ISBN: 9811903948
Category : Medical
Languages : en
Pages : 216
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Book Description
This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.
Author: Kenan Demir
Publisher: Cambridge Scholars Publishing
ISBN: 1527565394
Category : Medical
Languages : en
Pages : 199
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Book Description
The collection of essays reviews and explores current issues concerning glycolipids in their broadest sense. Its overview of glycolipids, gangliosides and ceramides, and their connection with related diseases, the immune system, cancer and infections offers a comprehensive presentation of current trends, data and possible developments in health sciences, pharmacology and industry.
Author: Marilena Aquino de Muro
Publisher: Springer Nature
ISBN: 107162895X
Category : Medical
Languages : en
Pages : 204
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Book Description
This detailed volume spotlights methods to investigate a variety of virus-host interactions in humans, other mammals, fish, or insects. It explores viruses such as white spot syndrome virus (WSSV), honeybee viruses, Nipah virus, EBV, SVCV, HSV-1, HIV-1, A H1N1, and SARS-CoV-2, as well as applications of techniques such as qPCR, serum antibody responses, 4C analysis, cell membrane fusion, biosensors, computational modelling, quantitative proteomics, and other genetic tools to decipher those viral infections and interactions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Virus-Host Interactions: Methods and Protocols serves as a valuable resource for researchers both in academia and in the biosciences industry who are engaged in the search for a better understanding of threatening virus-hosts interactions, virus detection, their characterization, and ultimately their taming and control.
Author: Neale Ridgway
Publisher: Elsevier
ISBN: 0444634495
Category : Science
Languages : en
Pages : 625
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Book Description
Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. - Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry - References from current literature will be included in each chapter to facilitate more in-depth study - Key concepts are supported by figures and models to improve reader understanding - Chapters provide historical perspective and current analysis of each topic
Author: Vinood Patel
Publisher: Academic Press
ISBN: 0128112980
Category : Technology & Engineering
Languages : en
Pages : 462
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Book Description
The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts. Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more. - Summarizes molecular nutrition in health as related to fats - Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease - Includes preclinical, clinical and population studies - Covers the genome, the whole body and whole communities - Includes key facts, a mini dictionary of terms and summary points
Author: Kim Ekroos
Publisher: John Wiley & Sons
ISBN: 3527655964
Category : Science
Languages : en
Pages : 507
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Book Description
Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical drug discovery and development. The editor and authors have experience of the most recent analytical instruments and techniques, allowing them to provide here first-hand practical experience for newcomers to the field. The first half of the book covers current methodologies, ranging from global to targeted lipidomics and shotgun approaches, while the second part discusses the role of lipidomics in biomedical and pharmaceutical research, covering such diverse fields as inflammation, metabolic syndrome, cardiovascular and neurological disease. Both small and large-scale, high-throughput approaches are discussed, resulting in an invaluable source for academic and industrial research and development.
Author: Charles Chalfant
Publisher: Springer Science & Business Media
ISBN: 1441967419
Category : Science
Languages : en
Pages : 311
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Book Description
This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Author: Stefan Dübel
Publisher: John Wiley & Sons
ISBN: 3527682449
Category : Science
Languages : en
Pages : 2538
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Book Description
Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.
