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Author: Casper Rønn Hoeck
Publisher: Springer
ISBN: 3319961721
Category : Science
Languages : en
Pages : 271
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Book Description
This book explores how nuclear magnetic resonance (NMR) spectroscopy may be used for spatial structural elucidation of novel compounds from fungal and synthetic sources. Readers will discover the exciting world of NOE (nuclear Overhauser effect), RDC (residual dipolar coupling) and J-coupling constants, both short- and long range. With emphasis on obtaining structural knowledge from these NMR observables, focus is moved from solving a static 3D structure to solving the structural space inhabited by small organic molecules. The book outlines the development and implementation of two Heteronuclear Multiple Bond Correlation-type NMR experiments, and the 3D structural elucidation of multiple known and novel compounds. In addition, a new method of back-calculating RDCs (allowing for more flexible structures to be investigated), and the synthesis and evaluation of novel chiral alignment media for ab initio determination of absolute stereochemistry of small molecules using RDCs are also included. Challenges that 3D structural generation of small compounds face are also covered in this work.
Author: Casper Rønn Hoeck
Publisher: Springer
ISBN: 3319961721
Category : Science
Languages : en
Pages : 271
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Book Description
This book explores how nuclear magnetic resonance (NMR) spectroscopy may be used for spatial structural elucidation of novel compounds from fungal and synthetic sources. Readers will discover the exciting world of NOE (nuclear Overhauser effect), RDC (residual dipolar coupling) and J-coupling constants, both short- and long range. With emphasis on obtaining structural knowledge from these NMR observables, focus is moved from solving a static 3D structure to solving the structural space inhabited by small organic molecules. The book outlines the development and implementation of two Heteronuclear Multiple Bond Correlation-type NMR experiments, and the 3D structural elucidation of multiple known and novel compounds. In addition, a new method of back-calculating RDCs (allowing for more flexible structures to be investigated), and the synthesis and evaluation of novel chiral alignment media for ab initio determination of absolute stereochemistry of small molecules using RDCs are also included. Challenges that 3D structural generation of small compounds face are also covered in this work.
Author: Casper Hoeck
Publisher:
ISBN: 9788793476424
Category :
Languages : en
Pages :
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Book Description
Author: Joseph P. Zbilut
Publisher: Elsevier
ISBN: 0080474691
Category : Science
Languages : en
Pages : 252
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Book Description
Traditionally, randomness and determinism have been viewed as being diametrically opposed, based on the idea that causality and determinism is complicated by "noise. Although recent research has suggested that noise can have a productive role, it still views noise as a separate entity. This work suggests that this not need to be so. In an informal presentation, instead, the problem is traced to traditional assumptions regarding dynamical equations and their need for unique solutions. If this requirement is relaxed, the equations admit for instability and stochasticity evolving from the dynamics itself. This allows for a decoupling from the "burden of the past and provides insights into concepts such as predictability, irreversibility, adaptability, creativity and multi-choice behaviour. This reformulation is especially relevant for biological and social sciences whose need for flexibility a propos of environmental demands is important to understand: this suggests that many system models are based on randomness and nondeterminism complicated with a little bit of determinism to ultimately achieve concurrent flexibility and stability. As a result, the statistical perception of reality is seen as being a more productive tool than classical determinism. The book addresses scientists of all disciplines, with special emphasis at making the ideas more accessible to scientists and students not traditionally involved in the formal mathematics of the physical sciences. The implications may be of interest also to specialists in the philosophy of science.·Presents the ideas in an informal language.·Provides tools for exploring data for singularities.
Author: Belle Wallace
Publisher: Routledge
ISBN: 1843121077
Category : Education
Languages : en
Pages : 171
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Book Description
This book tells teachers all they need to know about multiple intelligences and problem solving and provides a bank of problems that can be integrated into any lesson plan.
Author: Naoki Sugimoto
Publisher: Springer Nature
ISBN: 9811997764
Category : Science
Languages : en
Pages : 2847
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Book Description
This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.
Author: Neocles Leontis
Publisher: Springer Science & Business Media
ISBN: 3642257402
Category : Science
Languages : en
Pages : 402
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Book Description
With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.
Author: Arnab Kumar Maji
Publisher: Springer Nature
ISBN: 9813340843
Category : Technology & Engineering
Languages : en
Pages : 731
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Book Description
This book contains the latest research work presented at the International Conference on Computing and Communication Systems (I3CS 2020) held at North-Eastern Hill University (NEHU), Shillong, India. The book presents original research results, new ideas and practical development experiences which concentrate on both theory and practices. It includes papers from all areas of information technology, computer science, electronics and communication engineering written by researchers, scientists, engineers and scholar students and experts from India and abroad.
Author: Adam Liwo
Publisher: Springer
ISBN: 3319958437
Category : Technology & Engineering
Languages : en
Pages : 849
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Book Description
This book provides a comprehensive overview of modern computer-based techniques for analyzing the structure, properties and dynamics of biomolecules and biomolecular processes. It is organized in four main parts; the first one deals with methodology of molecular simulations; the second one with applications of molecular simulations; the third one introduces bioinformatics methods and the use of experimental information in molecular simulations; the last part reports on selected applications of molecular quantum mechanics. This second edition has been thoroughly revised and updated to include the latest progresses made in the respective field of research.
Author: Molly Fitzgerald-Hayes
Publisher: Academic Press
ISBN: 008091635X
Category : Science
Languages : en
Pages : 401
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Book Description
Appropriate for a wide range of disciplines, from biology to non-biology, law and nursing majors, DNA and Biotechnology uses a straightforward and comprehensive writing style that gives the educated layperson a survey of DNA by presenting a brief history of genetics, a clear outline of techniques that are in use, and highlights of breakthroughs in hot topic scientific discoveries. Engaging and straightforward scientific writing style Comprehensive forensics chapter Parallel Pedagogic material designed to help both readers and teachers Highlights in the latest scientific discoveries Outstanding full-color illustration that walk reader through complex concepts
Author: Wallace Wang
Publisher: Springer Nature
ISBN: 3031322029
Category : Computers
Languages : en
Pages : 281
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Book Description
The Structure of Game Design is designed to help aspiring and existing game designers turn their ideas into working games. Creating a game involves understanding the core foundational elements of all types of games from paper-based games to the latest video games. By understanding how these core principles work in all types of games, you can apply these same principles to design your own game. Games are about goals, structure, play and fun. While everyone will always have their own idea of what might be “fun”, any game designer can maximize player enjoyment through meaningful choices that offer various risks and rewards. Such challenges, combined with rules and limitations, force players to overcome obstacles and problems using a variety of skills including dexterity, puzzle solving, intelligence, and strategy. Essentially games allow players to venture forth into new worlds and overcome problems in a safe but exciting environment that allows them to triumph in the end. Just as playing games have proven popular around the world to all ages, genders, and cultures, so has game designing proven equally popular. Games can challenge players to make the best move, solve puzzles, engage in combat, manage resources, and tell stories. By understanding how randomness, psychology, and balance can change the way games play, readers can decide what game elements are best for their own game creation. Whether your goal is to make money, learn something new, make a social statement, improve on an existing game idea, or challenge your artistic, programming, or design skills, game design can be just as much fun as game playing. By knowing the parts of a game, how they work, how they interact, and why they’re fun, you can use your knowledge to turn any idea into a game that others can play and enjoy.
