Silica Nanoparticles with Encapsulated DNA (SPED) to Trace the Spread of Pathogens in Healthcare PDF Download
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Author: Cinzia Ullrich
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Cinzia Ullrich
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ISBN:
Category :
Languages : en
Pages : 0
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Author: Manuela Scotoni
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Category :
Languages : en
Pages : 0
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 60
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Author: Pengchao Sun
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Pengchao Sun
Publisher:
ISBN:
Category :
Languages : en
Pages : 130
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Author: Michael Aaron Vrolijk
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 216
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Book Description
DNA and interfering RNA (RNAi) -- short interfering RNA (siRNA) and micro RNA (miRNA) -- are promising new cancer therapies, especially for drug resistant lines. However, they require a delivery system in vivo to prevent degradation and off target effects. Silica based nanoparticles, both solid and mesoporous, are a promising option due to their biocompatibility, ease of preparation and morphology control, reproducibility, and facile addition of functional groups including targeting ligands. After a brief introduction to cancer treatment and review of the current nanoparticle treatments undergoing clinical trials, this thesis details the many methods explored over the past ten years to fine-tune particle preparation, pore size, functionalization, and delivery strategies. The majority of both solid and mesoporous silica nanoparticles are synthesized using the sol-gel method and then various functionalization techniques are employed to load and protect the oligonucleotides. Externally loaded systems generally use a combination of polyethylenimine (PEI) and polyethylene glycol (PEG). Mesoporous silica nanoparticles internally load the DNA or RNAi, resulting in the added variable of pore size. Several groups have investigated how pore size alters loading and release kinetics to perfect this variable. Many groups have also tested ligands targeting for over expressed proteins on the intended cancer, triggered release techniques, cell-penetrating peptides in order to create a viable in vivo delivery system. By compiling the techniques employed by researchers over the past ten years, this thesis will elucidate which approaches are most promising for future research. Furthermore, overall strategies within the field are suggested to more easily compare studies and evaluate methods.
Author: Juan Vivero-Escoto
Publisher:
ISBN: 9781613244524
Category : Biotechnology
Languages : en
Pages : 0
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In this book, the authors present topical research in the study of the preparation, properties and use of silica nanoparticles. Topics discussed include the reactivity of inorganic radicals and excited triplet states in colloidal silica suspensions; multifunctional mesoporous silica nanoparticles for controlled drug delivery, multimodal imaging and simultaneous imaging and drug delivery; monodisperse luminescent silica nanoparticles and their application to DNA microarray technology.
Author: Carsten Kneuer
Publisher:
ISBN:
Category :
Languages : en
Pages : 143
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Author: Luigi Pasqua
Publisher: Smithers Rapra
ISBN: 1847355099
Category : Medical
Languages : en
Pages : 182
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This book provides an insightful understanding of the mesoporous silica structure and its special properties. The details of synthesis and modification strategies are discussed by reviewing the open literature. The discussion concerning the potential of mesoporous silica in modern biomedical applications will be related to a critical analysis in the field of material science. This book will help the reader rapidly develop the necessary tools to follow the design of the different mesoporous silica-based devices presented in the various studies. The structure of the different devices is examined in detail and the relationship between the structure and the expected activity are discussed. It will also assist in the ability to design new therapeutic devices in a field where the applications seem to be without limits.
Author: Claudia A. Deuber
Publisher:
ISBN:
Category :
Languages : en
Pages :
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