Author: Mordechai Liscovitch
Publisher: Landes Bioscience
ISBN:
Category : Science
Languages : en
Pages : 258
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Book Description
This book examines signal-activated phospholipases, a class of cellular enzymes activated in response to hormones, neurotransmitters, growth factors, cytokines, and other agonists. The signal-activated phospholipases produce a host of lipid-derived second messengers that mediate agonist and cell type-specific responses.
Author: Paramjit S. Tappia
Publisher: Springer Science & Business Media
ISBN: 1493904647
Category : Science
Languages : en
Pages : 416
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Book Description
Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
Author:
Publisher: Academic Press
ISBN: 0128039469
Category : Science
Languages : en
Pages : 232
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Book Description
This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field. Contributions from leading authorities Informs and updates on all the latest developments in the field of enzymes
Author: John N. Fain
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 384
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Book Description
Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Major topics covered include: * Techniques for examining the role of phosphoinositides in signal transduction * Techniques related to protein kinase C * Analysis of inositol phosphates * Techniques to analyze phospholipid turnover in the brain
Author: Edward A. Dennis
Publisher: Wiley-Liss
ISBN: 9780471516026
Category : Science
Languages : en
Pages : 404
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Book Description
Explores cell activation and its relation to membrane receptor events linked to various phospholipases which produce lipid second messengers. Topics discussed include phospholipase A2s, lipocortins, phospholipase Cs, protein phosphorylation and protein kinase C, the role of inositol phosphates in Ca2 mobilization, platelet activating factor, and PAF production by epithelial cells.
Author: Edward A. Dennis
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 420
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Book Description
Author: Xuemin Wang
Publisher: Springer Science & Business Media
ISBN: 3642420117
Category : Science
Languages : en
Pages : 232
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Book Description
This volume focuses on recent advances in the biochemical and molecular analysis of different families of phospholipases in plants and their roles in signaling plant growth, development and responses to abiotic and biotic cues. The hydrolysis of membrane lipids by phospholipases produces different classes of lipid mediators, including phosphatidic acid, diacylglycerol, lysophospholipids, free fatty acids and oxylipins. Phospholipases are grouped into different families and subfamilies according to their site of hydrolysis, substrate usage and sequence similarities. Activating one or more of these enzymes often constitutes an early, critical step in many regulatory processes, such as signal transduction, vesicular trafficking, secretion and cytoskeletal rearrangements. Lipid-based signaling plays pivotal roles in plant stress responses, cell size, shape, growth, apoptosis, proliferation, and reproduction.
Author: Roland Benz
Publisher: Wiley-VCH Verlag GmbH
ISBN: 9783527307753
Category : Eukaryotic Cells
Languages : en
Pages : 0
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Book Description
For the first time, current knowledge on this important of proteins is now available in a single resource. This first book on porins in prokaryotes and eukaryotes relates the known physiological functions of porins to their molecular structure and mechanism. It brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function. From the contents: Structure of Prokaryotic Porins Functional Reconstitution of Porins Regulation of Bacterial Porin Function Role of Porins in Antibiotic Susceptibility Drug Efflux and Protein Export through Porins Structure and Function of Mitochondrial Porins VDAC Function in Intracellular Signalling and Apoptosis With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this important protein family.
Author: Inbal Hazan
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
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Book Description
Author: Inbal Hazan-Hallevy
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
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Book Description
