The Genetics of African Populations in Health and Disease

The Genetics of African Populations in Health and Disease PDF Author: Muntaser E. Ibrahim
Publisher: Cambridge University Press
ISBN: 1107072026
Category : History
Languages : en
Pages : 351

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Book Description
A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

The Genetics of African Populations in Health and Disease

The Genetics of African Populations in Health and Disease PDF Author: Muntaser E. Ibrahim
Publisher: Cambridge University Press
ISBN: 1107072026
Category : History
Languages : en
Pages : 351

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Book Description
A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Sickle Cell Disease in Sub-Saharan Africa, Public Health Perspectives

Sickle Cell Disease in Sub-Saharan Africa, Public Health Perspectives PDF Author: Baba Inusa
Publisher:
ISBN: 9781032729411
Category : Medical
Languages : en
Pages : 0

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Book Description
This fascinating collection examines the socio-economic factors that impact the well-being of patients with Sickle-Cell Disease (SCD) in sub-Saharan Africa, and the critical importance of patient advocacy in the region. The book looks at a number of key issues, including the social determinants that influence the spread of the disease, the quality of life of children with SCD, the impact of stigma, and the broader psychosocial burden of such a prevalent condition. There are also chapters on policy and Public Health management, including collaborations with NGOs and global partners. The second in a two-volume set offering a multi-disciplinary perspective on SCD, this insightful collection highlights many of the hidden issues faced across the region. It will be important reading for students of both Public Health and Medicine, as well as practitioners working for governments or NGOs.

Sickle Cell Disease in Sub-Saharan Africa, Public Health Perspectives

Sickle Cell Disease in Sub-Saharan Africa, Public Health Perspectives PDF Author: Baba Inusa
Publisher:
ISBN: 9781003467748
Category : Chronically ill
Languages : en
Pages : 0

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Book Description
"This fascinating collection examines the socio-economic factors that impact the well-being of patients with Sickle-Cell Disease (SCD) in sub-Saharan Africa, and the critical importance of patient advocacy in the region. The book looks at a number of key issues, including the social determinants that influence the spread of the disease, the quality of life of children with SCD, the impact of stigma, and the broader psychosocial burden of such a prevalent condition. There are also chapters on policy and Public Health management, including collaborations with NGOs and global partners. The second in a two-volume set offering a multi-disciplinary perspective on SCD, this insightful collection highlights many of the hidden issues faced across the region. It will be important reading for students of both Public Health and Medicine, as well as practitioners working for governments or NGOs"--

Disease and Mortality in Sub-Saharan Africa

Disease and Mortality in Sub-Saharan Africa PDF Author: Dean T. Jamison
Publisher: World Bank Publications
ISBN: 0821363980
Category : Medical
Languages : en
Pages : 414

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Book Description
Current data and trends in morbidity and mortality for the sub-Saharan Region as presented in this new edition reflect the heavy toll that HIV/AIDS has had on health indicators, leading to either a stalling or reversal of the gains made, not just for communicable disorders, but for cancers, as well as mental and neurological disorders.

The Management of Sickle Cell Disease

The Management of Sickle Cell Disease PDF Author: U. S. Department of Health
Publisher: Createspace Independent Publishing Platform
ISBN: 9781495279157
Category : Sickle cell anemia
Languages : en
Pages : 0

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Book Description
#1 Best Seller on Sickle Cell Disease (SCD). Sickle cell disease is a group of blood disorders passed down from parents to children. Sickle cell anemia shortens life expectancy by 30 years via bacterial infections, painful swellings, fever, arthritis, leg ulcers, eye, lung & heart damage. Over 100,000 people, mostly African-Americans, in the United States have sickle cell disease. Over 2 million people have sickle cell trait in America. It is estimated that more than 300,000 children are born each year with SCD around the world. This edition of The Management of Sickle Cell Disease (SCD) is organized into four parts: 1. Diagnosis and Counseling 2. Health Maintenance 3. Treatment of Acute and Chronic Complications 4. Special Topics. The original intent was to incorporate evidence-based medicine into each chapter, but there was variation among evidence-level scales, and some authors felt recommendations could be made, based on accepted practice, without formal trials in this rare disorder. The best evidence still is represented by randomized, controlled trials (RCTs), but variations exist in their design, conduct, endpoints, and analyses. It should be emphasized that selected people enter a trial, and results should apply in practice specifically to populations with the same characteristics as those in the trial. Randomization is used to reduce imbalances between groups, but unexpected factors sometimes may confound analysis or interpretation. In addition, a trial may last only a short period of time, but long-term clinical implications may exist. Another issue is treatment variation, for example, a new pneumococcal vaccine developed after the trial, which has not been tested formally in a sickle cell population. Earlier trial results may be accepted, based on the assumption that the change is small. In some cases, RCTs cannot be done satisfactorily (e.g., for ethical reasons, an insufficient number of patients, or a lack of objective measures for sickle cell "crises"). Thus the bulk of clinical experience in SCD still remains in the moderately strong and weaker categories of evidence. Not everyone has an efficacious outcome in a clinical trial, and the frequency of adverse events, such as with long-term transfusion programs or hematopoietic transplants, might not be considered. Thus, an assessment of benefit-to-risk ratio should enter into translation of evidence levels into practice recommendations. A final issue is that there may be two alternative approaches that are competitive (e.g., transfusions and hydroxyurea). In this case the pros and cons of each course of treatment should be discussed with the patient. This book is B&W copy of the government agency publication.

Sickle Cell Disease in Sub-Saharan Africa

Sickle Cell Disease in Sub-Saharan Africa PDF Author: Baba Inusa
Publisher: Taylor & Francis
ISBN: 1040011780
Category : Medical
Languages : en
Pages : 169

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Book Description
This fascinating collection examines the socio-economic factors that impact the well-being of patients with sickle cell disease (SCD) in Sub-Saharan Africa and the critical importance of patient advocacy in the region. The book looks at a number of key issues, including the social determinants that influence the spread of the disease, the quality of life of children with SCD, the impact of stigma and the broader psychosocial burden of such a prevalent condition. There are also chapters on policy and Public Health management, including collaborations with non-governmental organisations (NGOs) and global partners. The second in a two-volume set offering a multi-disciplinary perspective on SCD, this insightful collection highlights many of the hidden issues faced across the region. It will be important reading for students of both Public Health and Medicine, as well as practitioners working for governments or NGOs.

Empowerment Evaluation Principles in Practice

Empowerment Evaluation Principles in Practice PDF Author: David M. Fetterman
Publisher: Guilford Press
ISBN: 1462506712
Category : Psychology
Languages : en
Pages : 244

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Book Description
What principles should guide an empowerment evaluation? And how can these principles actually be put into practice? One of the primary tasks in an empowerment evaluation (EE) is to increase the capacity of program stakeholders to plan, implement, and evaluate their own programs. This book presents the most current formulation of the 10 principles of EE and provides professionals and students with the tools to put these principles into practice. Through case studies of diverse evaluation projects--including community health foundation initiatives, school district programs, and a $15 million corporate program aimed at bridging the digital divide--the founder and leading proponents of EE clarify key concepts and discuss important lessons learned. Coverage includes how to balance program improvement efforts with accountability requirements; how EE can be used to guide standards-based work; how to use EE in a learning organization; the differences among empowerment, collaborative, and participatory evaluation; and much more.

Genomics and Health in the Developing World

Genomics and Health in the Developing World PDF Author: Dhavendra Kumar
Publisher: Oxford University Press
ISBN: 019970547X
Category : Medical
Languages : en
Pages : 1569

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Book Description
Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation--with particular emphasis on medical and health issues--in the emerging economies and countries of the developing world. With sections dedicated to fundamtals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights the importance of utilizing genetics/genomics knowledge to promote and achieve optimal health in the developing world. Grouped by geographic region, the chapters in this volume address: - Inherited disorders in the developing world, including a thorough look at genetic disorders in minority groups of every continent - The progress of diagnostic laboratory genetic testing, prenatal screening, and genetic counseling worldwide - Rising ethical and legal concerns of medical genetics in the developing world - Social, cultural, and religious issues related to genetic diseases across continents Both timely and vastly informative, this book is a unique and comprehensive resource for genetists, clinicians, and public health professionals interested in the social, ethical, economic, and legal matters associated with medical genetics in the developing world.

Strategizing National Health in the 21st Century

Strategizing National Health in the 21st Century PDF Author: World Health Organization
Publisher:
ISBN: 9789241549745
Category : Medical
Languages : en
Pages : 0

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Book Description
This handbook was designed to provide up-to-date and practical guidance on national health planning and strategizing for health. It establishes a set of best practices to support strategic plans for health and represents the wealth of experience accumulated by WHO on national health policies, strategies, and plans (NHPSPs). WHO has been one of the leading organizations to support countries in the development of NHPSPs. The focus on improving plans has grown in recent years in recognition of the benefits of anchoring a strong national health sector in a written vision based on participation, analysis, and evidence.

The Enculturated Gene

The Enculturated Gene PDF Author: Duana Fullwiley
Publisher: Princeton University Press
ISBN: 1400840414
Category : Social Science
Languages : en
Pages : 369

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Book Description
In the 1980s, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African populations. After casual observations of how patients managed this painful blood disorder, the researchers in question postulated that the Senegalese type was less severe. The Enculturated Gene traces how this genetic discourse has blotted from view the roles that Senegalese patients and doctors have played in making sickle cell "mild" in a social setting where public health priorities and economic austerity programs have forced people to improvise informal strategies of care. Duana Fullwiley shows how geneticists, who were fixated on population differences, never investigated the various modalities of self-care that people developed in this context of biomedical scarcity, and how local doctors, confronted with dire cuts in Senegal's health sector, wittingly accepted the genetic prognosis of better-than-expected health outcomes. Unlike most genetic determinisms that highlight the absoluteness of disease, DNA haplotypes for sickle cell in Senegal did the opposite. As Fullwiley demonstrates, they allowed the condition to remain officially invisible, never to materialize as a health priority. At the same time, scientists' attribution of a less severe form of Senegalese sickle cell to isolated DNA sequences closed off other explanations of this population's measured biological success. The Enculturated Gene reveals how the notion of an advantageous form of sickle cell in this part of West Africa has defined--and obscured--the nature of this illness in Senegal today. Some images inside the book are unavailable due to digital copyright restrictions.