Author: William D. Willis Jr.
Publisher: Springer Science & Business Media
ISBN: 1461500370
Category : Medical
Languages : en
Pages : 604
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Book Description
The third edition of this monograph continues to have the goal of providing an overview of current thought about the spinal cord mechanisms that are responsible for sensory processing. We hope that the book is of value to both basic and clinical neuroscientists. Several changes have been made in the presentation, as well as additions because of the research advances that have been made during the past decade. Chapters 3 and 4 in the previous edition have been subdivided, and now the morphology of primary afferent neu rons of the dorsal root ganglia is described in Chapter 3 and the chemical neuroanatomy 4. The description of the dorsal hom in the previous Chapter 4 of these neurons in Chapter is now included in Chapter 5, and the chemical neuroanatomy of the dorsal hom in Chapter 6. Furthermore, discussions of the descending control systems have now been of Chapter 12. consolidated at the end The authors would like to express their appreciation for the help provided by several individuals. R.E.C. wishes to acknowledge the many things he learned about primary afferent neurons from conversations with Dr S. N. Lawson. He also thanks Lyn Shilling for her assistance with the typing. WDW thanks Dr Nada Lawand for her critical reading of parts of the manuscript, Rosaline Leigh for help with the manuscript, and Griselda Gonzales for preparing the illustrations.
Author: William D. Willis
Publisher:
ISBN:
Category : Afferent pathways
Languages : en
Pages : 962
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Book Description
Author: William D. Willis Jr.
Publisher: Springer Science & Business Media
ISBN: 1461500354
Category : Medical
Languages : en
Pages : 1016
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Book Description
The third edition of this monograph continues to have the goal of providing an overview of current thought about the spinal cord mechanisms that are responsible for sensory processing. We hope that the book is of value to both basic and clinical neuroscientists. Several changes have been made in the presentation, as well as additions because of the research advances that have been made during the past decade. Chapters 3 and 4 in the previous edition have been subdivided, and now the morphology of primary afferent neu rons of the dorsal root ganglia is described in Chapter 3 and the chemical neuroanatomy of these neurons in Chapter 4. The description of the dorsal horn in the previous Chapter 4 is now included in Chapter 5, and the chemical neuroanatomy of the dorsal horn in Chapter 6. Furthermore, discussions of the descending control systems have now been consolidated at the end of Chapter 12. The authors would like to express their appreciation for the help provided by several individuals. R.E.C. wishes to acknowledge the many things he learned about primary afferent neurons from conversations with Dr S. N. Lawson. He also thanks Lyn Shilling for her assistance with the typing. WDW thanks Dr Nada Lawand for her critical reading of parts of the manuscript, Rosaline Leigh for help with the manuscript, and Griselda Gonzales for preparing the illustrations.
Author: William D. Willis
Publisher: Springer Science & Business Media
ISBN: 9780306437816
Category : Medical
Languages : en
Pages : 598
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Book Description
This monograph thoroughly examines the latest theory and research concerning spinal cord mechanisms of sensory processing. The book begins with a historical review of the organization of the peripheral nervous system is outlined in terms of sensory receptors and primary afferent axons. The authors examine the dorsal horn and the structure and function of dorsal horn internurons, and neurophysiological evidence concerning the location of sensory pathways in the spinal cord white matter. After te dorsal column, dorshlateral fasciculus, and the ventral quadrant are covered, the final chapter summarizes knowledge on receptors and spinal cord pathways of various sensations, including touch-pressure, flutter-vibration, pain, temperature, position sense, visceral sensation, and descending control systems.
Author: William D. Willis Jr.
Publisher: Springer Science & Business Media
ISBN: 1489905979
Category : Medical
Languages : en
Pages : 583
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Book Description
As stated in the preface to the first edition, the goal of this monograph is to provide an overview of current thought about the spinal cord mechanisms responsible for sensory processing. We hope that the book will be of value to both basic neuroscientists and clinicians. The organization of the monograph has followed the original plan in most respects, although the emphasis has changed with respect to many topics because of recent advances. In particular, a substantial increase in the number of investigations of the dorsal root ganglion has led us to devote a chapter to this topic. The treatment of chemical neuroanatomy in the dorsal horn, as well as the relevant neuropharmacology, has also been expanded considerably. Another major emphasis is on the results of experiments employing microneurography in human subjects. We thank Margie Watson and Lyn Schilling for their assistance with the typing and Griselda Gonzales for preparing the illustrations.
Author: Alexander Rabchevsky
Publisher: Frontiers Media SA
ISBN: 2889193969
Category : Physiology
Languages : en
Pages : 222
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Book Description
Traumatic injury of the spinal cord affects the entire organism directly and indirectly. Primary injury destroys neurons and severs axons which participate in neural circuits. Secondary injuries and pathologies arise from numerous sources including systemic inflammation, consequential damage of cutaneous, muscular, and visceral tissues, and dysregulation of autonomic, endocrine and sensory- motor functions. Evidence is mounting that spinal cord injury (SCI) affects regions of the nervous system spatially remote from the injury site, as well as peripheral tissues, and alters some basic characteristics of primary afferent cell biology and physiology (cell number, size/frequency, electrophysiology, other). The degree of afferent input and processing above the lesion is generally intact, while that in the peri-lesion area is highly variable, though pathologies emerge in both regions, including a variety of pain syndromes. Primary afferent input to spinal regions below the injury and the processing of this information becomes even more important in the face of complete or partial loss of descending input because such spared sensory processing can lead to both adaptive and pathological outcomes. This issue hosts review and research articles considering mechanisms of plasticity of primary afferent neurons and sensory processing after SCI, and how such plasticity contributes to sparing and/or recovery of functions, as well as exacerbation of existing and/or emergent pathologies. A critical issue for the majority of the SCI community is chronic above-, peri-, and below-level neuropathic pain, much of which may arise, at least in part, from plasticity of afferent fibers and nociceptive circuitry. For example, autonomic dysreflexia is common hypertensive syndrome that often develops after SCI that is highly reliant on maladaptive nociceptive sensory input and processing below the lesion. Moreover, the loss of descending input leaves the reflexive components of bladder/bowel/sexual function uncoordinated and susceptible to a variety of effects through afferent fiber plasticity. Finally, proper afferent feedback is vital for the effectiveness of activity-dependent rehabilitative therapies, but aberrant nociceptive input may interfere with these approaches since they are often unchecked due to loss of descending modulation.
Author: F. Cervero
Publisher: Springer Science & Business Media
ISBN: 1461308259
Category : Science
Languages : en
Pages : 508
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Book Description
This book constitutes the proceedings of a NATO Advanced Research Workshop held in El Escorial (Spain) from 22 -27 May 1988 with the title Processing of sensory information in the superficial dorsal hom of the spinal cord. Included in the book are reports of most of the main lectures given at the meeting, section introductions written by each session Chairman, section reports compiled by session rapporteurs and some short papers invited from authors of communications given in poster form. The latter were selected on the basis of being immediately relevant to the topic of the workshop and of originating from a laboratory not represented by the main speakers. All in all we believe that the reader can get a fair idea of the structure and general character of this Workshop. The overall aim of the meeting was to review the current state of knowledge on the role of the superficial dorsal horn of the mammalian spinal cord as a nucleus of relay and modulation of the somatic and visceral sensory input to the central nervous system. In this context, the contribution of this spinal cord region to the appreciation of pain was a central topic of discussion. Over the last decade there has been a considerable increase in anatomical, physiological and neurochemical studies of the superficial dorsal horn.
Author: W. D. Willis
Publisher: Springer
ISBN: 9781475716900
Category : Medical
Languages : en
Pages : 485
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Book Description
The goal of this monograph is to provide an overview of current thought about spinal cord mechanisms for sensory processing. We hope that the book will be useful both to basic neuroscientists and to clinicians. So me historical aspects of the problem and a few definitions are treated in the first chapter. The second chapter reviews the organiza tion of the peripheral nervous system from the standpoint of sensory receptors and primary afferent axons. The third chapter is concerned with what is known about the structure of the dorsal horn, while the fourth chapter considers the activity of dorsal horn interneurons. The clinical, behavioral, and neurophysiological evidence for what parts of the cord white matter contain particular sensory pathways is discussed in Chapter 5, and details about the various pathways in the dorsal columns, the dorsolateral fasciculus, and the ventral quadrant form the . subject matter of Chapters 6 through 8. The final chapter is an attempt to summarize what is presently known about the receptors and the spinal cord pathways responsible for the sensations of touch-pressure, flutter-vibration, pain, temperature, position sense and visceral sensa tion and about descending control systems.
Author: Laszlo Urban
Publisher: Springer Science & Business Media
ISBN: 3642787622
Category : Medical
Languages : en
Pages : 501
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Book Description
The research field of somatosensory processing in mammals has experienced revolutionary changes in recent years. Accumulation of basic and clinical data has greatly accelerated, and new phenomena have emerged. With the aid of new, refined methods, molecular and cellular changes have been described, underlying the signal transduction-transmission between the internal/external environment and the central nervous system have been described. The discovery of the interaction between the nervous and the immune system has, for example changed our view on the development of inflammatory diseases, while the cloning of genes encoding different trophic factors has boosted studies revealing profound changes in the regeneration of neurons, and induction of changes in phenotype. The study of the pre-and postsynaptic modulation of transmitter release, and the examination of the combined effects of amino acid and peptide transmitters has become recently possible by using cultured cell lines and in vitro techniques. Although it is in embryonic state, computational properties of single DRG cells under normal and pathological conditions are being investigated. Results soon or later will have a great impact on pain research and consequently ultimately in clinical pain management. This brief introduction indicates how our knowledge of the somatosensory system has increased dramatically recently. However, many investigators cultivate only a very specific field in the growing area of somatosensory research and find it difficult to integrate a more universal knowledge of their work.
Author:
Publisher:
ISBN:
Category : Electronic book
Languages : en
Pages : 221
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Book Description
