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Author: Urs Nydegger
Publisher: Springer Nature
ISBN: 3031322762
Category : Family & Relationships
Languages : en
Pages : 148
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Book Description
This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
Author: Urs Nydegger
Publisher: Springer Nature
ISBN: 3031322762
Category : Family & Relationships
Languages : en
Pages : 148
Get Book
Book Description
This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
Author:
Publisher: Elsevier
ISBN: 0443188874
Category : Science
Languages : en
Pages : 480
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Book Description
Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more. Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences
Author: Wang Zhiwei
Publisher: BoD – Books on Demand
ISBN: 9535109979
Category : Medical
Languages : en
Pages : 162
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Book Description
Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.
Author: Aise Seda Artis
Publisher: BoD – Books on Demand
ISBN: 9535105590
Category : Medical
Languages : en
Pages : 167
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Book Description
Hemodynamics is study of the mechanical and physiologic properties controlling blood pressure and flow through the body. The factors influencing hemodynamics are complex and extensive. In addition to systemic hemodynamic alterations, microvascular alterations are frequently observed in critically ill patients. The book "Hemodynamics: New Diagnostic and Therapeuric Approaches" is formed to present the up-to-date research under the scope of hemodynamics by scientists from different backgrounds.
Author: Stephen S. Hall
Publisher: HMH
ISBN: 0547561571
Category : Science
Languages : en
Pages : 452
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Book Description
A Discover Best Science Book of the Year: “A fascinating, accurate and accessible account of some of [the] contemporary efforts to combat aging” (The New York Times). Los Angeles Times Book Prize Finalist Named a Best Book of the Year by the New York Times, San Jose Mercury News, and Library Journal An award-winning writer explores science’s boldest frontier—extension of the human life span—interviewing dozens of people involved in the quest to allow us to live longer, better lives. Delving into topics from cancer to stem cells to cloning, Merchants of Immortality looks at humankind’s quest for longevity and tackles profound questions about our hopes for defeating health problems like heart attacks, Parkinson’s disease, and diabetes. The story follows a close-knit but fractious band of scientists as well as entrepreneurs who work in the shadowy area between profit and the public good. The author tracks the science of aging back to the iconoclastic Leonard Hayflick—who was the first to show that cells age, and whose epic legal battles with the federal government cleared the path for today’s biotech visionaries. Among those is the charismatic Michael West, a former creationist who founded the first biotech company devoted to aging research. West has won both ardent admirers and committed foes in his relentless quest to promote stem cells, therapeutic cloning, and other technologies of “practical immortality.” Merchants of Immortality breathes scintillating life into the most momentous science of our day, assesses the political and bioethical controversies it has spawned, and explores its potentially dramatic effect on the length and quality of our lives. “Timely and engrossing . . . This is top-drawer journalism.” —Publishers Weekly, starred review “A carefully documented examination of how society deals with life-and-death matters.” —Kirkus Reviews, starred review “An important survey of the entire landscape of the science aimed at extending human life.” —Newsday “[This] highly readable and important book . . . provide[s] new insights into the intersection of science and politics.” —The Washington Post
Author: Peter Uhlenberg
Publisher: Springer Science & Business Media
ISBN: 1402083564
Category : Family & Relationships
Languages : en
Pages : 758
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Book Description
The International Handbook of Population Aging examines research on a wide array of the profound implications of population aging. It demonstrates how the world is changing through population aging, and how demography is changing in response to it.
Author: Helen Atthowe
Publisher: Chelsea Green Publishing
ISBN: 1645021815
Category : Technology & Engineering
Languages : en
Pages : 385
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Book Description
The breakthrough resource for fruit and vegetable growers at every scale who want to go “beyond organic” and build higher soil quality and fertility using fewer inputs through a unique ecosystem-balancing approach. The Ecological Farm is the go-to guide for ecological growing, with a unique focus on reduced tillage, minimizing farm and garden inputs, and pest control. Reflecting the wisdom that farmer, consultant, and educator Helen Atthowe and her late husband, Carl Rosato, gained during decades of farming experience, this book guides readers on how to reduce or eliminate the use of outside inputs of fertilizer or pesticides—even those that are commonly used on certified organic orchards and market gardens. In clear language and with color photographs, charts, and graphs throughout, the book emphasizes the importance of managing the details of an entire growing system over the full life of the enterprise. Based on advances in scientific research in ecological food production, farmers, homesteaders, permaculturists, and gardeners alike will learn methods to: • design a farm system that maintains a growing root in the soil year-round to feed the microbial community instead of just crops • strengthen the “immune system” of a farm or garden • supply crop needs using only on-farm inputs such as cover crops and living mulch • maximize the presence of beneficial insects and microbes that support healthy crop development • minimize ecological impact in dealing with insect pest and disease problems This book also features a crop-by-crop guide to growing more than 25 of the most popular and profitable vegetables and fruits, including specific management advice for dealing with pests and diseases. The Ecological Farm makes complex, sometimes messy, ecological concepts and practices understandable to all growers, and makes healthy farming—in which nature is invited to participate—possible.
Author: Manfred Schwab
Publisher: Springer Science & Business Media
ISBN: 3540368477
Category : Medical
Languages : en
Pages : 3307
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Book Description
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Author: Alan Wolfe
Publisher: University of Chicago Press
ISBN: 9780226905174
Category : Political Science
Languages : en
Pages : 308
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Book Description
"Wolfe examines the ills of American society in the 1990s ... [and illustrates] the paradoxes of social criticism."--Jacket.
Author: Kay Heath
Publisher: State University of New York Press
ISBN: 0791477266
Category : Literary Criticism
Languages : en
Pages : 263
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Book Description
Uncovers the origins of midlife anxiety in Victorian print culture.
