SEEDLING Proposal to Establish Pilot Data for a Consortium on Magnetic Nanoparticle Assemblies: A New Tool for Drug Delivery, Sensors and Electronic Devices PDF Download
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Languages : en
Pages : 0
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Complexes of magnetic nanoparticles with polymer dispersion stabilizers can lead to well-defined magnetic dispersions and also to precursors for magnetic microspheres. Thus, complexes of block copolymers containing both hydrophilic and hydrophobic dispersion components with magnetite nanoparticles have been prepared and characterized. In-vitro cell survival assays of the hydrophilic complexes suggest a relationship between cell survival and proliferation and the molecular weight (and hydrophilicity) of the polymer dispersants (higher molecular weight results in better cell proliferation/survival). Magnetic transition metals such as cobalt, iron or nickel are susceptible to oxidation with concurrent loss in magnetic response unless the nanoparticle surfaces are protected with oxygen impermeable coatings. Copolymer precursors to graphitic-like and silica-like protective coatings have been prepared and utilized to coat cobalt nanoparticles in thermolysis reactions. High temperature pyrolyses of the complexes in both cases suggest that oxidatively stable cobalt nanoparticles approximately 10 nm in diameter can be formed. The pyrolysis procedure results in 10-nm cobalt but the particles are adhered together. Attention will be devoted during the forthcoming year on methods for separating the nanoparticles from each other and on 're-coating' the materials with appropriate biospecific functional groups.
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Languages : en
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Book Description
Complexes of magnetic nanoparticles with polymer dispersion stabilizers can lead to well-defined magnetic dispersions and also to precursors for magnetic microspheres. Thus, complexes of block copolymers containing both hydrophilic and hydrophobic dispersion components with magnetite nanoparticles have been prepared and characterized. In-vitro cell survival assays of the hydrophilic complexes suggest a relationship between cell survival and proliferation and the molecular weight (and hydrophilicity) of the polymer dispersants (higher molecular weight results in better cell proliferation/survival). Magnetic transition metals such as cobalt, iron or nickel are susceptible to oxidation with concurrent loss in magnetic response unless the nanoparticle surfaces are protected with oxygen impermeable coatings. Copolymer precursors to graphitic-like and silica-like protective coatings have been prepared and utilized to coat cobalt nanoparticles in thermolysis reactions. High temperature pyrolyses of the complexes in both cases suggest that oxidatively stable cobalt nanoparticles approximately 10 nm in diameter can be formed. The pyrolysis procedure results in 10-nm cobalt but the particles are adhered together. Attention will be devoted during the forthcoming year on methods for separating the nanoparticles from each other and on 're-coating' the materials with appropriate biospecific functional groups.
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Languages : en
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This project has entailed the development of magnetic materials with potential suitability as vehicles for magnetic field-directed drug delivery, and the design and implementation of a laboratory-scale instrument for measuring the magnetophoretic behavior of new materials in flowing media. Triblock copolymers comprised of hydrophilic poly(ethylene oxide) tail blocks and a polyurethane anchor block containing carboxylic acid binding groups were designed and synthesized. A method for preparing stabilized dispersions of magnetite nanoparticles coated with the stabilizers was developed, and these coated nanoparticles could be dispersed in water. Dispersions of the particle-copolymer complexes remained stable (did not separate) when these materials were dialyzed rigorously and subjected to repeated centrifugation steps to eliminate potentially toxic extractables. An in-vitro assay of toxicity was developed to assess cell survival in the presence of the magnetite nanoparticle-copolymer complexes. A first generation magnet system was designed in collaboration with our colleagues at Stereotaxis (St. Louis, MO). This research scale magnetic guidance system is now in place at VA Tech.
Author: K. S. Joshy
Publisher: Springer Nature
ISBN: 9811612609
Category : Technology & Engineering
Languages : en
Pages : 156
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Book Description
This volume covers current research in the usage of magnetic nanoparticles for drug delivery. It discusses synthesis methods, stabilizers used for surface coating on MNPs, and potential target ligands which can be used to ferry payloads to the targeted disease region. It also highlights the factors affecting delivery efficiency and toxicity, as well as the different routes of administration. The content also focus on the use of these carriers for gene therapy and to target brain tumors. This volume will be of interest to researchers working on drug discovery and delivery platforms.
Author: K. S. Joshy
Publisher:
ISBN: 9789811612619
Category :
Languages : en
Pages : 0
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Book Description
This volume covers current research in the usage of magnetic nanoparticles for drug delivery. It discusses synthesis methods, stabilizers used for surface coating on MNPs, and potential target ligands which can be used to ferry payloads to the targeted disease region. It also highlights the factors affecting delivery efficiency and toxicity, as well as the different routes of administration. The content also focus on the use of these carriers for gene therapy and to target brain tumors. This volume will be of interest to researchers working on drug discovery and delivery platforms.
Author: Mihail C. Roco
Publisher: Springer Science & Business Media
ISBN: 9401703590
Category : Technology & Engineering
Languages : en
Pages : 477
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Book Description
M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.
Author: Richard W. Siegel
Publisher: Springer Science & Business Media
ISBN: 9780792358541
Category : Technology & Engineering
Languages : en
Pages : 378
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Book Description
Timely information on scientific and engineering developments occurring in laboratories around the world provides critical input to maintaining the economic and technological strength of the United States. Moreover, sharing this information quickly with other countries can greatly enhance the productivity of scientists and engineers. These are some of the reasons why the National Science Foundation (NSF) has been involved in funding science and technology assessments comparing the United States and foreign countries since the early 1980s. A substantial number of these studies have been conducted by the World Technology Evaluation Center (WTEC) managed by Loyola College through a cooperative agreement with NSF. The National Science and Technology Council (NSTC), Committee on Technology's Interagency Working Group on NanoScience, Engineering and Technology (CT/IWGN) worked with WTEC to develop the scope of this Nanostucture Science and Technology report in an effort to develop a baseline of understanding for how to strategically make Federal nanoscale R&D investments in the coming years. The purpose of the NSTC/WTEC activity is to assess R&D efforts in other countries in specific areas of technology, to compare these efforts and their results to U. S. research in the same areas, and to identify opportunities for international collaboration in precompetitive research. Many U. S. organizations support substantial data gathering and analysis efforts focusing on nations such as Japan. But often the results of these studies are not widely available. At the same time, government and privately sponsored studies that are in the public domain tend to be "input" studies.
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Publisher: Academic Press
ISBN: 0128141700
Category : Medical
Languages : en
Pages : 224
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Book Description
Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Author: Richard Silberglitt
Publisher: Rand Corporation
ISBN: 0833041142
Category : Technology & Engineering
Languages : en
Pages : 332
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Book Description
In 2020, areas of particular importance for technology trends will include biotechnology, nanotechnology, materials technology, and information technology. This report, the companion document to The Global Technology Revolution 2020, Executive Summary (Silberglitt et al., MG-475-NIC, 2006), assesses in detail a sample of 29 countries with respect to their ability to acquire and implement 16 key technology applications.
Author: Richard G. Stevens
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 786
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Book Description
Author: V. P. Torchilin
Publisher: Imperial College Press
ISBN: 186094907X
Category : Technology & Engineering
Languages : en
Pages : 758
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Book Description
Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Sample Chapter(s). Chapter 1: Introduction. Nanocarriers for Drug Delivery: Needs and Requirements (442 KB). Contents: Nanoparticle Flow: Implications for Drug Delivery (A T Florence); Polymer Micelles as Drug Carriers (E V Batrakova et al.); Lipoproteins as Pharmaceutical Carriers (S Liu et al.); Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia); Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero); Magnetic Nanoparticles as Drug Carriers (U O Hnfeli & M Chastellain); Liposomal Drug Carriers in Cancer Therapy (A A Gabizon); Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw); Nanoparticles for Targeting Lymphatics (W Phillips); Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso); and other papers. Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging."
