Large-Scale Inference

Large-Scale Inference PDF Author: Bradley Efron
Publisher: Cambridge University Press
ISBN: 1139492136
Category : Mathematics
Languages : en
Pages :

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Book Description
We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.

Bayesian inference with INLA

Bayesian inference with INLA PDF Author: Virgilio Gomez-Rubio
Publisher: CRC Press
ISBN: 1351707205
Category : Mathematics
Languages : en
Pages : 330

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Book Description
The integrated nested Laplace approximation (INLA) is a recent computational method that can fit Bayesian models in a fraction of the time required by typical Markov chain Monte Carlo (MCMC) methods. INLA focuses on marginal inference on the model parameters of latent Gaussian Markov random fields models and exploits conditional independence properties in the model for computational speed. Bayesian Inference with INLA provides a description of INLA and its associated R package for model fitting. This book describes the underlying methodology as well as how to fit a wide range of models with R. Topics covered include generalized linear mixed-effects models, multilevel models, spatial and spatio-temporal models, smoothing methods, survival analysis, imputation of missing values, and mixture models. Advanced features of the INLA package and how to extend the number of priors and latent models available in the package are discussed. All examples in the book are fully reproducible and datasets and R code are available from the book website. This book will be helpful to researchers from different areas with some background in Bayesian inference that want to apply the INLA method in their work. The examples cover topics on biostatistics, econometrics, education, environmental science, epidemiology, public health, and the social sciences.

Bayesian Data Analysis, Third Edition

Bayesian Data Analysis, Third Edition PDF Author: Andrew Gelman
Publisher: CRC Press
ISBN: 1439840954
Category : Mathematics
Languages : en
Pages : 677

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Book Description
Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.

Geospatial Health Data

Geospatial Health Data PDF Author: Paula Moraga
Publisher: CRC Press
ISBN: 1000732150
Category : Medical
Languages : en
Pages : 216

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Book Description
Geospatial health data are essential to inform public health and policy. These data can be used to quantify disease burden, understand geographic and temporal patterns, identify risk factors, and measure inequalities. Geospatial Health Data: Modeling and Visualization with R-INLA and Shiny describes spatial and spatio-temporal statistical methods and visualization techniques to analyze georeferenced health data in R. The book covers the following topics: Manipulate and transform point, areal, and raster data, Bayesian hierarchical models for disease mapping using areal and geostatistical data, Fit and interpret spatial and spatio-temporal models with the Integrated Nested Laplace Approximations (INLA) and the Stochastic Partial Differential Equation (SPDE) approaches, Create interactive and static visualizations such as disease maps and time plots, Reproducible R Markdown reports, interactive dashboards, and Shiny web applications that facilitate the communication of insights to collaborators and policy makers. The book features fully reproducible examples of several disease and environmental applications using real-world data such as malaria in The Gambia, cancer in Scotland and USA, and air pollution in Spain. Examples in the book focus on health applications, but the approaches covered are also applicable to other fields that use georeferenced data including epidemiology, ecology, demography or criminology. The book provides clear descriptions of the R code for data importing, manipulation, modeling and visualization, as well as the interpretation of the results. This ensures contents are fully reproducible and accessible for students, researchers and practitioners.

Fueling Innovation and Discovery

Fueling Innovation and Discovery PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309254736
Category : Mathematics
Languages : en
Pages : 64

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Book Description
The mathematical sciences are part of everyday life. Modern communication, transportation, science, engineering, technology, medicine, manufacturing, security, and finance all depend on the mathematical sciences. Fueling Innovation and Discovery describes recent advances in the mathematical sciences and advances enabled by mathematical sciences research. It is geared toward general readers who would like to know more about ongoing advances in the mathematical sciences and how these advances are changing our understanding of the world, creating new technologies, and transforming industries. Although the mathematical sciences are pervasive, they are often invoked without an explicit awareness of their presence. Prepared as part of the study on the Mathematical Sciences in 2025, a broad assessment of the current state of the mathematical sciences in the United States, Fueling Innovation and Discovery presents mathematical sciences advances in an engaging way. The report describes the contributions that mathematical sciences research has made to advance our understanding of the universe and the human genome. It also explores how the mathematical sciences are contributing to healthcare and national security, and the importance of mathematical knowledge and training to a range of industries, such as information technology and entertainment. Fueling Innovation and Discovery will be of use to policy makers, researchers, business leaders, students, and others interested in learning more about the deep connections between the mathematical sciences and every other aspect of the modern world. To function well in a technologically advanced society, every educated person should be familiar with multiple aspects of the mathematical sciences.

Probability and Bayesian Modeling

Probability and Bayesian Modeling PDF Author: Jim Albert
Publisher: CRC Press
ISBN: 1351030132
Category : Mathematics
Languages : en
Pages : 553

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Book Description
Probability and Bayesian Modeling is an introduction to probability and Bayesian thinking for undergraduate students with a calculus background. The first part of the book provides a broad view of probability including foundations, conditional probability, discrete and continuous distributions, and joint distributions. Statistical inference is presented completely from a Bayesian perspective. The text introduces inference and prediction for a single proportion and a single mean from Normal sampling. After fundamentals of Markov Chain Monte Carlo algorithms are introduced, Bayesian inference is described for hierarchical and regression models including logistic regression. The book presents several case studies motivated by some historical Bayesian studies and the authors’ research. This text reflects modern Bayesian statistical practice. Simulation is introduced in all the probability chapters and extensively used in the Bayesian material to simulate from the posterior and predictive distributions. One chapter describes the basic tenets of Metropolis and Gibbs sampling algorithms; however several chapters introduce the fundamentals of Bayesian inference for conjugate priors to deepen understanding. Strategies for constructing prior distributions are described in situations when one has substantial prior information and for cases where one has weak prior knowledge. One chapter introduces hierarchical Bayesian modeling as a practical way of combining data from different groups. There is an extensive discussion of Bayesian regression models including the construction of informative priors, inference about functions of the parameters of interest, prediction, and model selection. The text uses JAGS (Just Another Gibbs Sampler) as a general-purpose computational method for simulating from posterior distributions for a variety of Bayesian models. An R package ProbBayes is available containing all of the book datasets and special functions for illustrating concepts from the book. A complete solutions manual is available for instructors who adopt the book in the Additional Resources section.

Bayesian Inference for Gene Expression and Proteomics

Bayesian Inference for Gene Expression and Proteomics PDF Author: Kim-Anh Do
Publisher: Cambridge University Press
ISBN: 052186092X
Category : Mathematics
Languages : en
Pages : 437

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Book Description
Expert overviews of Bayesian methodology, tools and software for multi-platform high-throughput experimentation.

Bayesian Modeling and Computation in Python

Bayesian Modeling and Computation in Python PDF Author: Osvaldo A. Martin
Publisher: CRC Press
ISBN: 1000520048
Category : Computers
Languages : en
Pages : 420

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Book Description
Bayesian Modeling and Computation in Python aims to help beginner Bayesian practitioners to become intermediate modelers. It uses a hands on approach with PyMC3, Tensorflow Probability, ArviZ and other libraries focusing on the practice of applied statistics with references to the underlying mathematical theory. The book starts with a refresher of the Bayesian Inference concepts. The second chapter introduces modern methods for Exploratory Analysis of Bayesian Models. With an understanding of these two fundamentals the subsequent chapters talk through various models including linear regressions, splines, time series, Bayesian additive regression trees. The final chapters include Approximate Bayesian Computation, end to end case studies showing how to apply Bayesian modelling in different settings, and a chapter about the internals of probabilistic programming languages. Finally the last chapter serves as a reference for the rest of the book by getting closer into mathematical aspects or by extending the discussion of certain topics. This book is written by contributors of PyMC3, ArviZ, Bambi, and Tensorflow Probability among other libraries.

Multiscale Modeling

Multiscale Modeling PDF Author: Marco A.R. Ferreira
Publisher: Springer Science & Business Media
ISBN: 0387708979
Category : Business & Economics
Languages : en
Pages : 243

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Book Description
This highly useful book contains methodology for the analysis of data that arise from multiscale processes. It brings together a number of recent developments and makes them accessible to a wider audience. Taking a Bayesian approach allows for full accounting of uncertainty, and also addresses the delicate issue of uncertainty at multiple scales. These methods can handle different amounts of prior knowledge at different scales, as often occurs in practice.

Doing Meta-Analysis with R

Doing Meta-Analysis with R PDF Author: Mathias Harrer
Publisher: CRC Press
ISBN: 1000435636
Category : Mathematics
Languages : en
Pages : 500

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Book Description
Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered, including calculation and pooling of outcome measures, forest plots, heterogeneity diagnostics, subgroup analyses, meta-regression, methods to control for publication bias, risk of bias assessments and plotting tools. Advanced but highly relevant topics such as network meta-analysis, multi-three-level meta-analyses, Bayesian meta-analysis approaches and SEM meta-analysis are also covered. A companion R package, dmetar, is introduced at the beginning of the guide. It contains data sets and several helper functions for the meta and metafor package used in the guide. The programming and statistical background covered in the book are kept at a non-expert level, making the book widely accessible. Features • Contains two introductory chapters on how to set up an R environment and do basic imports/manipulations of meta-analysis data, including exercises • Describes statistical concepts clearly and concisely before applying them in R • Includes step-by-step guidance through the coding required to perform meta-analyses, and a companion R package for the book