Ruthenium Catalyzed Bis-Homo-Diels-Alder [2+2+2] Cycloaddition PDF Download
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Author: Dina Petko
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Synthetic organic chemistry is an integral part of pharmaceutical design and development, which builds upon past literature to create molecules that mimic nature. The synthesis of ring structures has long been a focus in synthetic organic chemistry as many biologically active molecules contain various ring systems. Cycloaddition reactions are a means of constructing rings ranging from three-membered rings to large macrocycles and can be thermally or photochemically allowed or require metal catalysts to proceed. This work examines the [2+2+2] Bis-Homo-Diels-Alder cycloaddition between 1,5- cyclooctadiene and various alkynes including: terminal and internal alkynes, alkynyl halides and alkynyl phosphonates. First, two commercially available ruthenium catalysts were identified as being able to catalyze this reaction and alkynes were screed for their reactivity towards this reaction. Next, alkynyl halides were used as partners in this reaction with the hopes that the halide moiety would be retained in the final product and provide a site for further modification. Lastly, the use of alkynyl phosphonates in this reaction was explored to synthesize an array of novel vinyl-phosphonate containing compounds.
![Ruthenium Catalyzed Bis-Homo-Diels-Alder [2+2+2] Cycloaddition PDF](https://books.google.com/books/content/images/frontcover/WPh7zgEACAAJ?fife=w80-h100)
Author: Dina Petko
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Synthetic organic chemistry is an integral part of pharmaceutical design and development, which builds upon past literature to create molecules that mimic nature. The synthesis of ring structures has long been a focus in synthetic organic chemistry as many biologically active molecules contain various ring systems. Cycloaddition reactions are a means of constructing rings ranging from three-membered rings to large macrocycles and can be thermally or photochemically allowed or require metal catalysts to proceed. This work examines the [2+2+2] Bis-Homo-Diels-Alder cycloaddition between 1,5- cyclooctadiene and various alkynes including: terminal and internal alkynes, alkynyl halides and alkynyl phosphonates. First, two commercially available ruthenium catalysts were identified as being able to catalyze this reaction and alkynes were screed for their reactivity towards this reaction. Next, alkynyl halides were used as partners in this reaction with the hopes that the halide moiety would be retained in the final product and provide a site for further modification. Lastly, the use of alkynyl phosphonates in this reaction was explored to synthesize an array of novel vinyl-phosphonate containing compounds.
![Ruthenium-Catalyzed [2+2] Cycloaddition Reactions Between a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene and Unsymmetrical Alkynes PDF](https://books.google.com/books/content/images/frontcover/bkjXtwEACAAJ?fife=w80-h100)
Author: Robin Durham
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Jan Hamer
Publisher:
ISBN:
Category : Diels-Alder reaction
Languages : en
Pages : 520
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Author: Pierre Vogel
Publisher: John Wiley & Sons
ISBN: 3527345329
Category : Science
Languages : en
Pages : 1386
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Book Description
Provides the background, tools, and models required to understand organic synthesis and plan chemical reactions more efficiently Knowledge of physical chemistry is essential for achieving successful chemical reactions in organic chemistry. Chemists must be competent in a range of areas to understand organic synthesis. Organic Chemistry provides the methods, models, and tools necessary to fully comprehend organic reactions. Written by two internationally recognized experts in the field, this much-needed textbook fills a gap in current literature on physical organic chemistry. Rigorous yet straightforward chapters first examine chemical equilibria, thermodynamics, reaction rates and mechanisms, and molecular orbital theory, providing readers with a strong foundation in physical organic chemistry. Subsequent chapters demonstrate various reactions involving organic, organometallic, and biochemical reactants and catalysts. Throughout the text, numerous questions and exercises, over 800 in total, help readers strengthen their comprehension of the subject and highlight key points of learning. The companion Organic Chemistry Workbook contains complete references and answers to every question in this text. A much-needed resource for students and working chemists alike, this text: -Presents models that establish if a reaction is possible, estimate how long it will take, and determine its properties -Describes reactions with broad practical value in synthesis and biology, such as C-C-coupling reactions, pericyclic reactions, and catalytic reactions -Enables readers to plan chemical reactions more efficiently -Features clear illustrations, figures, and tables -With a Foreword by Nobel Prize Laureate Robert H. Grubbs Organic Chemistry: Theory, Reactivity, and Mechanisms in Modern Synthesis is an ideal textbook for students and instructors of chemistry, and a valuable work of reference for organic chemists, physical chemists, and chemical engineers.
Author: Shun-Ichi Murahashi
Publisher: John Wiley & Sons
ISBN: 3527605797
Category : Science
Languages : en
Pages : 398
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Book Description
In this comprehensive book, one of the leading experts, Shun-Ichi Murahashi, presents all the important facets of modern synthetic chemistry using Ruthenium, ranging from hydrogenation to metathesis. In 14 contributions, written by an international authorship, readers will find all the information they need about this fascinating and extraordinary chemistry. The result is a high quality information source and a indispensable reading for everyone working in organometallic chemistry. From the contents: Introduction (S.-I. Murahashi) Hydrogenation and Transfer Hydrogenation (M. Kitamura and R. Noyori) Oxidations (S.-I. Murahashi and N. Komiya) Carbon-Carbon Bond Formations via Ruthenacycle Intermediates (K. Itoh) Carbon-Carbon Bond Formation via pi-Allylruthenium Intermediates (T. Mitsudo) Olefin Metathesis (R. H. Grubbs) Cyclopropanation (H. Nishiyama) Nucleophilic Addition to Alkynes and Reactions via Vinylidene Intermediates (P. Dixneuf) Reactions via C-H Activation (N. Chatani) Lewis Acid Reactions (E. P. Kundig) Reactions with CO and CO2 (T. Mitsudo) Isomerization of Organic Substrates Catalyzed by Ruthenium Complexes (H. Suzuki) Radical Reactions (H. Nagashima) Bond Cleavage Reactions (S. Komiya)
Author: Pierre Vogel
Publisher: John Wiley & Sons
ISBN: 3527819282
Category : Science
Languages : en
Pages : 280
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Book Description
This is the accompanying workbook to the textbook "Organic Chemistry - Theory, Reactivity and Mechanisms in Modern Synthesis" by P. Vogel and K. Houk.
![Exploration of Ruthenium-catalyzed [2+2] Cycloaddition and Iron-catalyzed Cross-coupling Reaction Wtih Bicyclic Alkenes PDF](https://books.google.com/books/content/images/frontcover/3zjNwgEACAAJ?fife=w80-h100)
Author: University of Guelph. Department of Chemistry and Biochemistry
Publisher:
ISBN: 9780494232705
Category :
Languages : en
Pages : 159
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Author: Lukas J. Gooßen
Publisher: Springer
ISBN: 3642342868
Category : Science
Languages : en
Pages : 345
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Book Description
Barry Trost: Transition metal catalyzed allylic alkylation.- Jeffrey W. Bode: Reinventing Amide Bond Formation.- Naoto Chatani and Mamoru Tobisu: Catalytic Transformations Involving the Cleavage of C-OMe Bonds.- Gregory L. Beutner and Scott E. Denmark: The Interplay of Invention, Observation and Discovery in the Development of Lewis Base Activation of Lewis Acids for Catalytic Enantioselective Synthesis.- David R. Stuart and Keith Fagnou: The Discovery and Development of a Palladium(II)-Catalyzed Oxidative Cross-Coupling of Two Unactivated Arenes.- Lukas Gooßen and Käthe Gooßen: Decarboxylative Cross-Coupling Reactions.- A. Stephen K. Hashmi: Gold-Catalyzed Organic Reactions.- Ben List: Developing Catalytic Asymmetric Acetalizations.- Steven M. Bischof, Brian G. Hashiguchi, Michael M. Konnick, and Roy A. Periana: The De NovoDesign of CH Bond Hydroxylation Catalysts.- Benoit Cardinal-David, Karl A. Scheidt: Carbene Catalysis: Beyond the Benzoin and Stetter Reactions.- Kenso Soai and Tsuneomi Kawasaki: Asymmetric autocatalysis of pyrimidyl alkanol.- Douglas C. Behenna and Brian M. Stoltz: Natural Products as Inspiration for Reaction Development: Catalytic Enantioselective Decarboxylative Reactions of Prochiral Enolate Equivalents. Hisashi Yamamoto: Acid Catalysis in Organic Synthesis.
Author: Ramon Rios Torres
Publisher: John Wiley & Sons
ISBN: 1118308638
Category : Science
Languages : en
Pages : 422
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Book Description
The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control. The Pauson-Khand Reaction investigates the nature and many variations of this reaction. Topics covered include: the mechanisms of Pauson‐Khand-type reactions non chiral intramolecular and intermolecular versions of Pauson‐Khand reactions asymmetric Pauson‐Khand reaction using chiral auxiliaries the enantioselective Pauson‐Khand reaction Pauson‐Khand reactions catalysed by metals other than cobalt unconventional Pauson‐Khand reactions the Pauson‐Khand reaction in total synthesis Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.
Author: Yimin Hu
Publisher:
ISBN:
Category :
Languages : en
Pages : 278
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