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Author: John Mitrofanis
Publisher: Morgan & Claypool Publishers
ISBN: 1643277200
Category : Science
Languages : en
Pages : 172
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Book Description
Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Author: John Mitrofanis
Publisher: Morgan & Claypool Publishers
ISBN: 1643277200
Category : Science
Languages : en
Pages : 172
Get Book Here
Book Description
Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Author: Laura King Edwards
Publisher:
ISBN: 9781945805837
Category : Neuronal ceroid-lipofuscinoses
Languages : en
Pages : 0
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Book Description
Laura has it all: a great job, a loving family, a new husband, and a house in her hometown, where she can watch her sister, Taylor, grow up. But one month after her wedding, Laura and her family receive shocking news: Taylor has Batten disease. A rare, fatal disease that will cause Taylor to go blind, suffer seizures, and lose the ability to walk and talk. There is no cure. Laura thought she'd get to watch her baby sister grow up, but instead she'll have to watch her die. Unwilling to take no cure for an answer, Laura founds a charity with family and friends, Taylor's Tale, to save children with the disease. Meanwhile, Taylor starts running, completing her first race blind. Inspired, Laura, a lifelong runner, begins running in half marathons to raise money and awareness. And also to run away from the pain. Taylor's Tale becomes a world leader in the fight against Batten disease, but not quickly enough to save Taylor. Stripped of her faith, Laura falls into a dark despair. But Taylor's unwavering courage in the face of certain death gives Laura a renewed sense of purpose to turn her family's tragedy into an opportunity--to ensure others won't have to suffer as her sister has suffered. Run to the Light is Laura's inspiring account of how she found the courage to face indescribable loss, and of what it means to really believe.
Author: Michael Sandler
Publisher: Crown
ISBN: 0307985946
Category : Sports & Recreation
Languages : en
Pages : 322
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Book Description
How could something we have for free—our bare feet—be better for running than $150 shoes? The truth is that running in shoes is high-impact, unstable, and inflexible. Shoes promote a heel-centric ground strike, which weakens your feet, knees, and hips, and leads to common running injuries. In contrast, barefoot running is low-impact, forefoot-centric, stable, and beneficial to your body. It encourages proper form and strengthens your feet in miraculous ways. When you run in shoes, you not only risk developing poor form, but you also hinder the natural relationship with the ground that running facilitates. Barefoot running restores the delightful sensory and spiritual connections to the earth that you were meant to experience. Barefoot Running offers the only step-by-step direction runners need at any age to overcome injuries, run faster than ever, and rediscover the pure joy of running. Once you tear off your shoes and learn to dance with nature, you’ll tread lightly and freely, hearing only the earth’s symphony and feeling only the dirt beneath your feet. Hit the ground running with revolutionary techniques for starting out slowly, choosing minimalist footwear, navigating rough weather and rugged terrain, and building your feet into living shoes.
Author: Baird Harper
Publisher: Simon and Schuster
ISBN: 1501147374
Category : Fiction
Languages : en
Pages : 197
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Book Description
A brilliant feat of storytelling, Red Light Run is the radiant and stunning debut from Best New American Voices writer Baird Harper. When two cars collide at an intersection in a leafy Chicago suburb, Hartley Nolan is not the person police expect to find behind the wheel. After all, he barely drinks; everyone knows it’s his wife who’s the alcoholic. But the bigger question on people’s minds is what brought Sonia Senn, dead at the scene, back to her hometown in such a hurry that night? In eleven tightly linked stories, Red Light Run pulls us into the inner lives of Hartley, Sonia, and a host of other characters to untangle the mounting forces that carry them to their fates. Among the ensemble in this prismatic collection are a real estate agent who seeks gossip on the market rather than houses, a trailer park developer whose entire livelihood is laid to waste by a single cigarette, a divorced mother battling her daughter-in-law for hegemony over her kitchen, a widower hell-bent on destroying the invasive species of beetle that’s wiping out his oak trees, and a down-and-out handyman with a desperate plan for revenge. And then there’s Sonia Senn, with a dark secret of her own, and Hartley Nolan, who has risen above his roots to become a commodities trader in Chicago only to end up sentenced to eight years at Grassland State Prison. With infectiously grim humor and wry insight, these characters contemplate their realities in relation to one tragic moment, propelling us toward a startling revelation about the long and sometimes crooked arc of justice.
Author: Wesley Cartier
Publisher: Houghton Mifflin Harcourt
ISBN: 9780152048280
Category : Juvenile Fiction
Languages : en
Pages : 28
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Book Description
"A boy runs so fast that he imagines himself to be a rabbit, a bobcat, a horse, and a cheetah."--[Source inconnue].
Author: Christopher McDougall
Publisher: Profile Books
ISBN: 184765228X
Category : Sports & Recreation
Languages : en
Pages : 296
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Book Description
A New York Times bestseller 'A sensation ... a rollicking tale well told' - The Times At the heart of Born to Run lies a mysterious tribe of Mexican Indians, the Tarahumara, who live quietly in canyons and are reputed to be the best distance runners in the world; in 1993, one of them, aged 57, came first in a prestigious 100-mile race wearing a toga and sandals. A small group of the world's top ultra-runners (and the awe-inspiring author) make the treacherous journey into the canyons to try to learn the tribe's secrets and then take them on over a course 50 miles long. With incredible energy and smart observation, McDougall tells this story while asking what the secrets are to being an incredible runner. Travelling to labs at Harvard, Nike, and elsewhere, he comes across an incredible cast of characters, including the woman who recently broke the world record for 100 miles and for her encore ran a 2:50 marathon in a bikini, pausing to down a beer at the 20 mile mark.
Author: Simran Jeet Singh
Publisher: Penguin
ISBN: 0525555099
Category : Juvenile Nonfiction
Languages : en
Pages : 49
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Book Description
The true story of Fauja Singh, who broke world records to become the first one hundred-year-old to run a marathon, shares valuable lessons on the source of his grit, determination to overcome obstacles, and commitment to positive representation of the Sikh community. Every step forward is a victory. Fauja Singh was born determined. He was also born with legs that wouldn't allow him to play cricket with his friends or carry him to school miles from his village in Punjab. But that didn't stop him. Working on his family's farm, Fauja grew stronger to meet his own full potential. He never stopped striving. At the age of 81, after a lifetime of making his body, mind, and heart stronger, Fauja decided to run his first marathon. He went on to break records all around the world and became the first person over 100 to complete the grueling long-distance race. With exuberant text by Simran Jeet Singh and exhilarating illustrations by Baljinder Kaur, the true story of Fauja Singh reminds us that it's both where we start and how we finish that make our journeys unforgettable.
Author: Eric Walters
Publisher: Penguin
ISBN: 0735270481
Category : Juvenile Fiction
Languages : en
Pages : 198
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Book Description
In conjunction with the Terry Fox Foundation, award-winning author Eric Walters brings Terry Fox and the Marathon of Hope to life for a whole new generation of young readers This first book for young readers about Terry Fox and the Marathon of Hope, written by one of Canada’s best-known writers for young adults, is a blending of fact and fiction, fully endorsed by The Terry Fox Foundation. Hundreds of thousands of young Canadians participate in the Terry Fox Run each year and this book will further enhance their knowledge of Terry’s epic journey. Run introduces a national hero to a new generation of readers. In his trademark page-turning style, Eric Walters, bestselling author of Trapped in Ice and Camp X, tells the story of Winston MacDonald. In trouble again after a suspension from school and a runaway attempt, Winston is sent to spend time with his father—a journalist who hasn’t been around much since his family split up a year ago. Travelling to Nova Scotia with his father, who is covering what he thinks is just a human interest story about a man trying to run across the country, Winston spends a day with Terry Fox and his best friend, Doug. Their determination to achieve what seems like an impossible goal makes a big impression on Winston, and he takes courage and inspiration from Terry’s run. He is overjoyed when his father’s article about the Marathon of Hope ignites public interest across the country. But when Winston discovers that his father’s next article about the Marathon of Hope will characterize Terry and Doug in an unflattering way, he is furious with his father and fearful of betraying his friends. Unsure of what to do or where to turn, Winston decides it is time to make a run for it himself...
Author: James Williams
Publisher:
ISBN: 1108429092
Category : Computers
Languages : en
Pages : 151
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Book Description
Argues that human freedom is threatened by systems of intelligent persuasion developed by tech giants who compete for our time and attention. This title is also available as Open Access.
Author: William Faulkner
Publisher: DigiCat
ISBN:
Category : Fiction
Languages : en
Pages : 363
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Book Description
DigiCat Publishing presents to you this special edition of "Light in August" by William Faulkner. DigiCat Publishing considers every written word to be a legacy of humankind. Every DigiCat book has been carefully reproduced for republishing in a new modern format. The books are available in print, as well as ebooks. DigiCat hopes you will treat this work with the acknowledgment and passion it deserves as a classic of world literature.
