Research and development landscape for childhood cancer

Research and development landscape for childhood cancer PDF Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240082530
Category : Medical
Languages : en
Pages : 16

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Book Description

Research and development landscape for childhood cancer

Research and development landscape for childhood cancer PDF Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240082530
Category : Medical
Languages : en
Pages : 16

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Book Description


Making Better Drugs for Children with Cancer

Making Better Drugs for Children with Cancer PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309181860
Category : Medical
Languages : en
Pages : 56

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Book Description
The successes that have been achieved in treating childhood cancers stand as beacons against the less dramatic improvements for adults with cancer. Progress began to accelerate in the 1960s and 1970s, as treatment regimens were built up, primarily by building combinations of chemotherapeutic drugs. However the near absence of research in pediatric cancer drug discovery threatens to halt the progress in childhood cancer treatment achieved during the past four decades. Making Better Drugs for Children with Cancer identifies the major issues to be addressed in developing new agents for childhood cancers, the gaps in research and development, and the steps that have been suggested to move the process forward. This report also makes a new proposal to capitalize on today's science to bring new treatments to children's cancers.

Shaping the global innovation and access landscape for better paediatric medicines

Shaping the global innovation and access landscape for better paediatric medicines PDF Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240044647
Category : Medical
Languages : en
Pages : 48

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Book Description
GAP-f’s three-year strategic plan (2022-2024) builds from the work undertaken to date by the network of leading partners, both individually and collectively, through GAP-f. With this strategy, GAP-f is excited to increase its footprint into a broader set of diseases to bring it closer to its vision of all children having equitable access to the medicines they need.

Childhood Cancer and Functional Impacts Across the Care Continuum

Childhood Cancer and Functional Impacts Across the Care Continuum PDF Author: National Academies of Sciences Engineering and Medicine
Publisher:
ISBN: 9780309683494
Category :
Languages : en
Pages :

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Book Description
Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

Childhood Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia PDF Author: Ajay Vora
Publisher: Springer
ISBN: 3319397087
Category : Medical
Languages : en
Pages : 345

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Book Description
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Pediatric Cancer Therapeutics Development

Pediatric Cancer Therapeutics Development PDF Author: Jorge DiMartino
Publisher: Springer Nature
ISBN: 3031063570
Category : Medical
Languages : en
Pages : 184

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Book Description
This book provides a comprehensive overview of the scientific, medical, regulatory, and economic considerations associated with the discovery, development, and delivery of novel therapeutics for children with cancer. Co-authored by a diverse team from academic, government, and industry backgrounds, the book describes the steps in the process from the identification of a promising therapeutic target to the evaluation of drug candidates in the various phases of clinical testing and regulatory review. Throughout, special emphasis is placed on the unique biology of pediatric malignancies and the medical and social needs of children and their families. In providing a firm grounding in the drug development process, the book will be of value to all with an interest in how medicines currently used to treat pediatric cancer were made available. This includes trainees as well as established practitioners and others participating in translational and clinical research in the academic setting.

A New Deal for Cancer

A New Deal for Cancer PDF Author: Abbe R. Gluck
Publisher: PublicAffairs
ISBN: 1541700627
Category : Medical
Languages : en
Pages : 416

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Book Description
An unprecedented constellation of experts—leading cancer doctors, policymakers, cutting-edge researchers, national advocates, and more—explore the legacy and the shortcomings from the fifty-year war on cancer and look ahead to the future. The longest war in the modern era, longer than the Cold War, has been the war on cancer. Cancer is a complex, evasive enemy, and there was no quick victory in the fight against it. But the battle has been a monumental test of medical and scientific research and fundraising acumen, as well as a moral and ethical challenge to the entire system of medicine. In A New Deal for Cancer, some of today’s leading thinkers, activists, and medical visionaries describe the many successes in the long war and the ways in which our deeper failings as a society have held us back from a more complete success. Together they present an unrivaled and nearly complete map of the battlefield across dimensions of science, government, equity, business, the patient provider experience, and more, documenting our emerging understanding of cancer’s many unique dimensions and offering bold new plans to enable the American health care system to deliver progress and hope to all patients.

Comprehensive Cancer Care for Children and Their Families

Comprehensive Cancer Care for Children and Their Families PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309374448
Category : Medical
Languages : en
Pages : 91

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Book Description
Childhood cancer is an area of oncology that has seen both remarkable progress as well as substantial continuing challenges. While survival rates for some pediatric cancers present a story of success, for many types of pediatric cancers, little progress has been made. Many cancer treatments are known to cause not only significant acute side effects, but also lead to numerous long-term health risks and reduced quality of life. Even in cases where the cancer is considered curable, the consequences of treatment present substantial long-term health and psychosocial concerns for children, their families, their communities, and our health system. To examine specific opportunities and suggestions for driving optimal care delivery supporting survival with high quality of life, the National Cancer Policy Forum of the Institute of Medicine and the American Cancer Society co-hosted a workshop which convened experts and members of the public on March 9 and 10, 2015. At this workshop, clinicians and researchers in pediatric oncology, palliative, and psychosocial care, along with representatives from the U.S. Food and Drug Administration, National Cancer Institute, Children's Oncology Group, pharmaceutical companies, and patient advocacy organizations, discussed and developed a menu of options for action to improve research, quality of care, and outcomes for pediatric cancer patients and their families. In addition, parents of children with cancer and pediatric cancer survivors shared their experiences with care and provided poignant personal perspectives on specific quality of life concerns and support needs for children and families across the life spectrum. This report summarizes the presentations and discussion of the workshop.

Landscape and Sustainable Development

Landscape and Sustainable Development PDF Author: Council of Europe
Publisher: Council of Europe
ISBN: 9287159890
Category : Science
Languages : en
Pages : 214

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Book Description
The Council of Europe landscape convention was adopted in Florence (Italy) on 20 October 2000 with the aim of promoting the protection, management and planning of European landscape and organising European co-operation in this area. It is the first international treaty covering all aspects of European landscape. It applies to the entire territory of the contracting parties and covers natural, rural, urban and peri-urban areas. It concerns landscapes that might be considered outstanding, commonplace or deteriorated. By taking into account landscape, culture and nature, the Council of Europe seeks to protect the quality of life and well-being of Europeans in a sustainable development perspective.

McCance & Huether’s Pathophysiology - E-Book

McCance & Huether’s Pathophysiology - E-Book PDF Author: Julia Rogers
Publisher: Elsevier Health Sciences
ISBN: 0323789897
Category : Medical
Languages : en
Pages : 1738

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Book Description
NEW! More than 50 new or revised illustrations visually reinforce pathophysiology concepts. NEW! Emerging Science boxes highlight the most current research and clinical developments.