Author: Kjell Fuxe
Publisher: Springer Science & Business Media
ISBN: 1468454153
Category : Computers
Languages : en
Pages : 577
Book Description
Receptor-Receptor Interactions
Author: Kjell Fuxe
Publisher: Springer Science & Business Media
ISBN: 1468454153
Category : Computers
Languages : en
Pages : 577
Book Description
Publisher: Springer Science & Business Media
ISBN: 1468454153
Category : Computers
Languages : en
Pages : 577
Book Description
Receptor-Receptor Interactions: A New Intramembrane Integrative Mechanism
Author: Kjell Fuxe
Publisher: Springer
ISBN: 1349089494
Category : Science
Languages : en
Pages : 577
Book Description
Publisher: Springer
ISBN: 1349089494
Category : Science
Languages : en
Pages : 577
Book Description
Affinity And Efficacy: The Components Of Drug-receptor Interactions
Author: Frederick J Ehlert
Publisher: World Scientific
ISBN: 9814632163
Category : Medical
Languages : en
Pages : 750
Book Description
The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug-receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book.The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed.
Publisher: World Scientific
ISBN: 9814632163
Category : Medical
Languages : en
Pages : 750
Book Description
The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug-receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book.The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed.
Receptor Binding Techniques
Author: Anthony P. Davenport
Publisher: Humana
ISBN: 9781588294203
Category : Medical
Languages : en
Pages : 240
Book Description
A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy transfer, and quantitative analysis of receptor mRNA by TaqMan PCR. These book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified.
Publisher: Humana
ISBN: 9781588294203
Category : Medical
Languages : en
Pages : 240
Book Description
A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy transfer, and quantitative analysis of receptor mRNA by TaqMan PCR. These book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified.
Receptor-receptor Interactions
Author: Yogesh C. Patel
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
Book Description
Toxicant-Receptor Interactions
Author: Michael Denison
Publisher: CRC Press
ISBN: 9781560326335
Category : Medical
Languages : en
Pages : 243
Book Description
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are directly related to the analysis of the molecular mechanism by which xenobiotics modulate signal transduction and gene expression.
Publisher: CRC Press
ISBN: 9781560326335
Category : Medical
Languages : en
Pages : 243
Book Description
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are directly related to the analysis of the molecular mechanism by which xenobiotics modulate signal transduction and gene expression.
Neurotransmitter-receptor Interactions
Author: D. J. Triggle
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 628
Book Description
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 628
Book Description
Textbook of Receptor Pharmacology
Author: John C. Foreman
Publisher: CRC Press
ISBN: 1420052551
Category : Medical
Languages : en
Pages : 314
Book Description
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica
Publisher: CRC Press
ISBN: 1420052551
Category : Medical
Languages : en
Pages : 314
Book Description
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica
Pharmacologic Analysis of Drug-receptor Interaction
Author: Terrence P. Kenakin
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 504
Book Description
A guide to quantitative drug-receptor pharmacology, this new edition aims to cover all receptor systems, whether derived from molecular biology or animal studies. Using existing data, it demonstrates how theoretical models facilitate drug development, and integrates theory with practice. This second edition aims to be a valuable resource for all researchers involved in the drug design and development process. Not only has the text been updated and revised, but reflecting the significant technical breakthroughs of recent years, it now more generally encompasses all receptor systems, whether derived from molecular biology or whole animal studies. These systems are examined within the framework of current drug receptor theories, particularly the receptor occupation theory, the operational model of drug action and the ternary complex model.
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 504
Book Description
A guide to quantitative drug-receptor pharmacology, this new edition aims to cover all receptor systems, whether derived from molecular biology or animal studies. Using existing data, it demonstrates how theoretical models facilitate drug development, and integrates theory with practice. This second edition aims to be a valuable resource for all researchers involved in the drug design and development process. Not only has the text been updated and revised, but reflecting the significant technical breakthroughs of recent years, it now more generally encompasses all receptor systems, whether derived from molecular biology or whole animal studies. These systems are examined within the framework of current drug receptor theories, particularly the receptor occupation theory, the operational model of drug action and the ternary complex model.
Frontiers in Pharmacology of Neurotransmitters
Author: Puneet Kumar
Publisher: Springer Nature
ISBN: 9811535566
Category : Medical
Languages : en
Pages : 729
Book Description
Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.
Publisher: Springer Nature
ISBN: 9811535566
Category : Medical
Languages : en
Pages : 729
Book Description
Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.