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Author: Peter Agre
Publisher: CRC Press
ISBN: 9780824780227
Category : Science
Languages : en
Pages : 768
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Book Description
This book is devoted to the red blood cell membrane, its structure and function, and abnormalities in disease states. It presents a well-documented and well-illustrated comprehensive picture of clinical manifestations of red blood cell disorders.
Author: Peter Agre
Publisher: CRC Press
ISBN: 9780824780227
Category : Science
Languages : en
Pages : 768
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Book Description
This book is devoted to the red blood cell membrane, its structure and function, and abnormalities in disease states. It presents a well-documented and well-illustrated comprehensive picture of clinical manifestations of red blood cell disorders.
Author: Antonio De Flora
Publisher: Springer Science & Business Media
ISBN: 1468459856
Category : Medical
Languages : en
Pages : 365
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Book Description
The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.
Author: Lars Kaestner
Publisher: Frontiers Media SA
ISBN: 2832550371
Category : Science
Languages : en
Pages : 101
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Book Description
We are now in the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Physiology. Frontiers has organized a series of Research Topics to highlight the latest advancements in science in order to be at the forefront of science in different fields of research. This editorial initiative of particular relevance, led by Profs . Anna Bogdanova and Lars Kaestner, Specialty Chief Editors of the Red Blood Cell Physiology section, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances and future perspectives in the field of Red Blood Cell Physiology.
Author: Oguz Baskurt
Publisher: CRC Press
ISBN: 1439841802
Category : Medical
Languages : en
Pages : 326
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Book Description
Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.
Author: Richard Van Wijk
Publisher: Frontiers Media SA
ISBN: 2889716996
Category : Science
Languages : en
Pages : 167
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Book Description
Topic Editors Dr. Paola Bianchi and Dr. Richard Van Wijk provide consultancy to Agios Pharmaceuticals. Dr. Richard Van Wijk has research support from RR Mechatronics and Agios Pharmaceuticals.
Author: Anna Bogdanova
Publisher: Frontiers Media SA
ISBN: 2889663515
Category : Science
Languages : en
Pages : 144
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Book Description
Author: Lars Kaestner
Publisher: Frontiers E-books
ISBN: 2889193489
Category : Biology (General)
Languages : en
Pages : 118
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Book Description
Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.
Author: Giampaolo Minetti
Publisher: Frontiers Media SA
ISBN: 2889666301
Category : Science
Languages : en
Pages : 157
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Book Description
Author: Lars Kaestner
Publisher: Frontiers Media SA
ISBN: 2889457028
Category :
Languages : en
Pages : 238
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Book Description
The eBook ‘The red cell life-cycle from erythropoiesis to clearance’ continues the discussion of questions like: What are the changes associated with red blood cell maturation, adulthood and senescence? What are the determinants of red blood cell life span and clearance? What are the mechanisms in control of red blood cell mass in healthy humans and patients with various forms of anaemia? Can red blood cells be 'trained' to provide the body with more oxygen during endurance exercises? What are the markers of circulating red blood cell senescence and in cells during storage and transfusion? And what can be learned from various species that developed advanced adaptations to maintain oxygen delivery under stress conditions such as exercising to the limit, diving or living in anaerobic aquatic habitats or at high altitude? Within the approximately 120 days (or 40 in a mouse, or 150-170 in a horse) life span of 'healthy' red blood cells, many cellular properties change leading to aged mixed cell populations in the circulation. Red blood cells seem to be genetically terminated by the time they become red blood cells and the contributions of this eBook increase the understanding of this process. There are surprisingly versatile remodeling processes happening during the red blood cell life span. Numerous disorders are associated with the premature onset of the 'ageing process' of red blood cells. Furthermore, in vitro ageing and/or modifications as well as the slowing down of the modifications is an important issue in transfusion medicine. Many of the molecular mechanisms behind such effects are elucidated in this eBook.
Author: Michigan Merino Sheep Breeders' Association
Publisher:
ISBN:
Category : Merino sheep
Languages : en
Pages : 362
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Book Description
