Author: Shirley Lehnert
Publisher: CRC Press
ISBN: 1439829039
Category : Medical
Languages : en
Pages : 504
Get Book Here
Book Description
Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must
Author: Nidha Gaba
Publisher: LAP Lambert Academic Publishing
ISBN: 9783844301960
Category :
Languages : en
Pages : 200
Get Book Here
Book Description
Radiotherapy is the most common modality for treating human cancers.Eighty percent of cancer patients need radiotherapy, either for curative or palliative purpose. Chemical modification is the concept in cancer therapy in which the state of tumor cells or normal tissues is modified such that the therapeutic gain can be achieved using conventional modalities. Radiosensitizers are the drugs that make cancer cells more sensitive to the effects of radiation therapy. Radioprotectors (also called radioprotectants) are drugs that protect normal (non cancerous) cells from the damage caused by radiation therapy. Therefore, chemical modifier field is developing novel approaches to the cancer treatment and increasing the understanding of the basics of cancer biology.
Author: Henning Willers
Publisher: Springer Nature
ISBN: 3030497011
Category : Medical
Languages : en
Pages : 370
Get Book Here
Book Description
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
Author: Tsutomu Sugahara
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 576
Get Book Here
Book Description
Author: Benjamin Frey
Publisher: Frontiers Media SA
ISBN: 2889745600
Category : Medical
Languages : en
Pages : 295
Get Book Here
Book Description
Author: Mirza Qaiser Baig
Publisher: JP Medical Ltd
ISBN: 9386150018
Category : Medical
Languages : en
Pages : 527
Get Book Here
Book Description
This book is a comprehensive guide to radiotherapy and chemotherapy providing clinicians with the most up to date thinking and latest advances in the field. Divided into five sections, the book begins with an overview of radiotherapy, its planning and techniques, followed by chapters on radiobiology explaining how radiotherapy works in the treatment of cancer. The next section explains the concepts of chemotherapy and common drugs, followed by detailed discussion on the planning and application of both radiotherapy and chemotherapy in the treatment of many different types of cancer. The final part of the book explains general management in oncology, covering the role of steroids and antacids, bleeding and anaemia, and treatment of pain. Key Points Comprehensive guide to radiotherapy and chemotherapy Discusses planning and application of both treatment methods Covers numerous different types of cancer Includes more than 300 images, diagrams and tables
Author: M. Guckenberger
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318063622
Category : Medical
Languages : en
Pages : 146
Get Book Here
Book Description
Developments in radiation oncology have been key to the tremendous progress made in the field in recent years. The combination of optimal systemic treatment and local therapy has resulted in continuing improved outcomes of cancer therapy. This progress forms the basis for current pre-clinical and clinical research which will strengthen the position of radiation oncology as an essential component of oncological care. This book summarizes recent advances in radiotherapy research and clinical patient care. Topics include radiobiology, radiotherapy technology, and particle therapy. Chapters cover a summary and analysis of recent developments in the search for biomarkers for precision radiotherapy, novel imaging possibilities and treatment planning, and advances in understanding the differences between photon and particle radiotherapy. Advances in Radiation Therapy is an invaluable source of information for scientists and clinicians working in the field of radiation oncology. It is also a relevant resource for those interested in the broad topic of radiotherapy in general.
Author: Yurui Wu
Publisher:
ISBN:
Category :
Languages : en
Pages : 74
Get Book Here
Book Description
Breast cancer is the most commonly diagnosed cancer among women and is the leading cause of cancer death in both developing and developed areas. Triple-negative breast cancer, one of the subtypes of breast cancer, is generally more aggressive and has fewer treatment options compared with other subtypes, due to the absence of drug-targetable receptors. Radiotherapy delivers ionizing radiation to cancerous areas, leading to DNA damage and cell death. There has been controversy about the molecular mechanism of DNA damage induced by ionizing radiation. According to conventional notions, biological damage by ionizing radiation is primarily induced by the hydroxyl radical, but Lu et al., using femtosecond time-resolved laser spectroscopy, have discovered that the dissociative electron transfer (DET) reaction of the weakly-bound prehydrated electron plays an important role in causing chemical bond and DNA strand breaks. Building on the better understanding of DET reaction mechanisms of prehydrated electron, the mechanism behind the radiosensitizing effect of cisplatin and halopyrimidines has been discovered by our group. However, cisplatin has severe toxicity, and the DET reaction efficiency of halopyrimidines is low. A newly discovered non-platinum-based compound, FMD-Br-DAB, identified through the femtomedicine approach, was tested in this research as a potential radiosensitizer. Our in vitro results have confirmed that FMD-Br-DAB can exert radiosensitizing effects on treated triple-negative breast cancer (MDA-MB-231) cells when combined with radiation. Our results also indicate that FMD-Br-DAB can enhance DNA damage in a dose-dependent manner when combined with radiation.
Author: A. Breccia
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 312
Get Book Here
Book Description
In July 1979, the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on "Nitroimidazoles: Chemistry, Pharmacology and Clinical Application." Because of the great interest in these drugs in various fields, I was very pleased to accept the proposal and to give the conference the sponsorship of the University of Bologna. It was an added pleasure to accept the chairmanship of the meeting, together with Professors Sensi and Adams. At the same time, the Minister of Education approved a proposal which also came from the Faculty of Pharmacy, to offer an advanced course on the topic "Radiosensitizers of Hypoxic Cells This course was subsequently approved by a special Committee of the NATO Scientific Programme as an Advanced Study Institute. Since the subject matter of both the conference and the course are closely inter-related, it was logical to plan the conference as part of the overall course. Bringing together specialists from quite different and apparently unrelated fields of research, but all with an interest in the study and application of one single group of drugs, is a novel idea with intriguing possibilities. The volumes of the proceedings include contributions from experts with such diverse interests as synthetic chemistry, mechanism of drug action, parasitology, anaerobic bacteria and protozoa, pharmacology and toxicology, radiation sensitizers for use in radiotherapy, and the development of drugs for use in cancer in general.
Author: Martin J. Brown
Publisher: Springer Science & Business Media
ISBN: 3540356622
Category : Medical
Languages : en
Pages : 346
Get Book Here
Book Description
The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.
